aLady Davis Institute for Medical Research

bDepartment of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University

cResearch Center, Sainte-Justine University Health Center

dDepartment of Pediatrics, University of Montreal, Montréal, Québec, Canada

Correspondence to Ernesto L. Schiffrin, MD, PhD, FRSC, FRCPC, FACP, Lady Davis Institute of Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, #F-126.1, 3755 Côte-Ste-Catherine Rd., Montréal, QC H3T 1E2, Canada. Tel: +1 514 340 8222 x25910; fax: +1 514 340 8732; e-mail: [email protected]

Abbreviations: AngII, angiotensin II; APC, allophycocyanin; AVG, average; BP, Blood pressure; CCL5, C-C motif chemokine ligand 5; CIHR, Canadian Institutes for Health Research; CRC, Canada Research Chair; DAMP, damage-associate molecular patterns; Exp, expression; FACS, fluorescence activated cell sorting; FDR, false discovery rate; GEM, gel beads-in-emulsion; GPR183, G protein receptor 183; IFN, interferon; IL, interleukin; NK, natural killer; PVAT, perivascular adipose tissue; SAT, subcutaneous adipose tissue; scRNA-seq, single-cell RNA-sequencing; TCR, T cell receptor; TEM, T effector memory; Trdc, TCR δ constant segment; Trdv4, T receptor δ variable 4; TReg-EM, T regulatory effector memory; Trgc1, TCR γ constant chain 1; UMAP, uniform manifold approximation and projection; γδT1cells, γδ T cells producing IFN-γ; γδT17 cells, γδ T cells producing IL-17

Received 5 December, 2023

Revised 23 January, 2024

Accepted 8 March, 2024

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