aDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester

bDivision of Medicine and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust Manchester

cWellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

Correspondence to Sushant Saluja, University of Manchester School of Medicine: The University of Manchester Faculty of Biology Medicine and Health, Manchester, United Kingdom. E-mail: [email protected]