aDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha

bDepartment of Pharmacy, First hospital of Nanchang, Nanchang

cInstitute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University

dEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education

eNational Clinical Research Center for Geriatric Disorders, Changsha

fKey Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou

gDepartment of Hypertension, Xingsha Hospital, Changsha, China

hDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Maryland, USA

Correspondence to Qing Li, Xiangya Hospital Central South University, China. E-mail: [email protected]

Abbreviations: ARBs, angiotensin type II receptor blockers; BP, blood pressure; CAT, catalase; Cgn, cingulin; F/B, Firmicutes/Bacteroidetes; FMT, fecal microbiota transplantation; GSH, glutathione; LEfSe, linear discriminate analysis effect size; MDA, malondialdehyde; Ocln, occluding; OTUs, operational taxonomic units; SCFAs, short-chain fatty acids; SHR, spontaneously hypertensive rat; SOD, superoxide dismutase; Tjp-1, tight junction protein 1; WKY, Wistar–Kyoto

Received 25 September, 2023

Revised 23 October, 2023

Accepted 25 October, 2023

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