Agarwal D, Sandor C, Volpato V, Caffrey TM, Monzon-Sandoval J, Bowden R et al (2020) A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders. Nat Commun 11:4183. https://doi.org/10.1038/s41467-020-17876-0

Article  PubMed  PubMed Central  Google Scholar 

Altay MF, Liu AKL, Holton JL, Parkkinen L, Lashuel HA (2022) Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders. Acta Neuropathol Commun 10:163. https://doi.org/10.1186/s40478-022-01468-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asi YT, Simpson JE, Heath PR, Wharton SB, Lees AJ, Revesz T et al (2014) Alpha-synuclein mRNA expression in oligodendrocytes in MSA. Glia 62:964–970. https://doi.org/10.1002/glia.22653

Article  PubMed  PubMed Central  Google Scholar 

Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G et al (2021) Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. Acta Neuropathol 141:159–172. https://doi.org/10.1007/s00401-020-02255-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beyer K, Lao JI, Carrato C, Mate JL, Lopez D, Ferrer I et al (2004) Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies. Neuropathol Appl Neurobiol 30:601–607. https://doi.org/10.1111/j.1365-2990.2004.00572.x

Article  CAS  PubMed  Google Scholar 

Bido S, Muggeo S, Massimino L, Marzi MJ, Giannelli SG, Melacini E et al (2021) Microglia-specific overexpression of alpha-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity. Nat Commun 12:6237. https://doi.org/10.1038/s41467-021-26519-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borrageiro G, Haylett W, Seedat S, Kuivaniemi H, Bardien S (2018) A review of genome-wide transcriptomics studies in Parkinson’s disease. Eur J Neurosci 47:1–16. https://doi.org/10.1111/ejn.13760

Article  PubMed  Google Scholar 

Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24:197–211. https://doi.org/10.1016/s0197-4580(02)00065-9

Article  PubMed  Google Scholar 

Braak H, Sastre M, Del Tredici K (2007) Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease. Acta Neuropathol 114:231–241. https://doi.org/10.1007/s00401-007-0244-3

Article  CAS  PubMed  Google Scholar 

Buccitelli C, Selbach M (2020) mRNAs, proteins and the emerging principles of gene expression control. Nat Rev Genet 21:630–644. https://doi.org/10.1038/s41576-020-0258-4

Article  CAS  PubMed  Google Scholar 

Cavaliere F, Cerf L, Dehay B, Ramos-Gonzalez P, De Giorgi F, Bourdenx M et al (2017) In vitro alpha-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains. Neurobiol Dis 103:101–112. https://doi.org/10.1016/j.nbd.2017.04.011

Article  CAS  PubMed  Google Scholar 

Chiba-Falek O, Lopez GJ, Nussbaum RL (2006) Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. Mov Disord 21:1703–1708. https://doi.org/10.1002/mds.21007

Article  PubMed  Google Scholar 

Chu Y, Muller S, Tavares A, Barret O, Alagille D, Seibyl J et al (2019) Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain 142:3565–3579. https://doi.org/10.1093/brain/awz296

Article  PubMed  PubMed Central  Google Scholar 

Dachsel JC, Lincoln SJ, Gonzalez J, Ross OA, Dickson DW, Farrer MJ (2007) The ups and downs of alpha-synuclein mRNA expression. Mov Disord 22:293–295. https://doi.org/10.1002/mds.21223

Article  PubMed  Google Scholar 

Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L et al (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 106:13010–13015. https://doi.org/10.1073/pnas.0903691106

Article  PubMed  PubMed Central  Google Scholar 

Dijkstra AA, Ingrassia A, de Menezes RX, van Kesteren RE, Rozemuller AJ, Heutink P et al (2015) Evidence for immune response, axonal dysfunction and reduced endocytosis in the substantia Nigra in early stage Parkinson’s disease. PLoS ONE 10:e0128651. https://doi.org/10.1371/journal.pone.0128651

Article  CAS  PubMed  PubMed Central  Google Scholar 

Djelloul M, Holmqvist S, Boza-Serrano A, Azevedo C, Yeung MS, Goldwurm S et al (2015) Alpha-synuclein expression in the oligodendrocyte lineage: an in vitro and in vivo study using rodent and human models. Stem Cell Reports 5:174–184. https://doi.org/10.1016/j.stemcr.2015.07.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duffy PE, Tennyson VM (1965) Phase and electron micromicroscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus caeruleus in Parkinson’s disease. J Neuropathol Exp Neurol 24:398–414

Article  Google Scholar 

Edfors F, Danielsson F, Hallstrom BM, Kall L, Lundberg E, Ponten F et al (2016) Gene-specific correlation of RNA and protein levels in human cells and tissues. Mol Syst Biol 12:883

Article  PubMed  PubMed Central  Google Scholar 

Erskine D, Patterson L, Alexandris A, Hanson PS, McKeith IG, Attems J et al (2018) Regional levels of physiological alpha-synuclein are directly associated with Lewy body pathology. Acta Neuropathol 135:153–154. https://doi.org/10.1007/s00401-017-1787-6

Article  CAS  PubMed  Google Scholar 

Espay AJ, Okun MS (2023) Abandoning the proteinopathy paradigm in Parkinson disease. JAMA Neurol 80:123–124. https://doi.org/10.1001/jamaneurol.2022.4193

Article  PubMed  Google Scholar 

Ezzat K, Sturchio A, Espay AJ (2023) The shift to a proteinopenia paradigm in neurodegeneration. Handb Clin Neurol 193:23–32. https://doi.org/10.1016/B978-0-323-85555-6.00001-1

Article  PubMed  Google Scholar 

Farrer M, Kachergus J, Forno L, Lincoln S, Wang DS, Hulihan M et al (2004) Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann Neurol 55:174–179. https://doi.org/10.1002/ana.10846

Article  CAS  PubMed  Google Scholar 

Flones IH, Nyland H, Sandnes DA, Alves GW, Tysnes OB, Tzoulis C (2022) Early forms of alpha-synuclein pathology are associated with neuronal complex I deficiency in the substantia Nigra of individuals with Parkinson’s disease. Biomolecules. https://doi.org/10.3390/biom12060747

Article  PubMed  PubMed Central  Google Scholar 

Forrest SL, Lee S, Nassir N, Martinez-Valbuena I, Sackmann V, Li J et al (2023) Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy. Acta Neuropathol 146:395–414. https://doi.org/10.1007/s00401-023-02604-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujishiro H, Imamura AY, Lin WL, Uchikado H, Mark MH, Golbe LI et al (2013) Diversity of pathological features other than Lewy bodies in familial Parkinson’s disease due to SNCA mutations. Am J Neurodegener Dis 2:266–275

PubMed  PubMed Central  Google Scholar 

Goedert M, Spillantini MG, Del Tredici K, Braak H (2013) 100 years of Lewy pathology. Nat Rev Neurol 9:13–24. https://doi.org/10.1038/nrneurol.2012.242

Article  CAS  PubMed  Google Scholar 

Grundemann J, Schlaudraff F, Haeckel O, Liss B (2008) Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson’s disease. Nucleic Acids Res 36:e38. https://doi.org/10.1093/nar/gkn084

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gry M, Rimini R, Stromberg S, Asplund A, Ponten F, Uhlen M et al (2009) Correlations between RNA and protein expression profiles in 23 human cell lines. BMC Genomics 10:365. https://doi.org/10.1186/1471-2164-10-365

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM et al (2002) Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions. J Biol Chem 277:49071–49076. https://doi.org/10.1074/jbc.M208046200

Article  CAS  PubMed  Google Scholar 

Holec SAM, Liu SL, Woerman AL (2022) Consequences of variability in alpha-synuclein fibril structure on strain biology. Acta Neuropathol 143:311–330. https://doi.org/10.1007/s00401-022-02403-w

Article  CAS  PubMed  Google Scholar 

Hu C, Li T, Xu Y, Zhang X, Li F, Bai J et al (2023) Cell Marker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data. Nucleic Acids Res 51:D870–D876. https://doi.org/10.1093/nar/gkac947

Article  CAS  PubMed  Google Scholar 

Katsuse O, Iseki E, Marui W, Kosaka K (2003) Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies. J Neurol Sci 211:29–35. https://doi.org/10.1016/s0022-510x(03)00037-6