Fu QR, Wei C, Wang MZ. Transition-metal-based nanozymes: synthesis, mechanisms of therapeutic action, and applications in cancer treatment. ACS Nano. 2024;18:12049–95. https://doi.org/10.1021/acsnano.4c02265.

Article  CAS  PubMed  Google Scholar 

Liu JS, Ma DC, Li YB, Li JD. Revealing mechanism of transition metals doping in chlorapatite as single-atom nanozymes for high electrocatalytic activity of Fenton/ Fenton-like reaction. Sep Purif Technol. 2024;336. https://doi.org/10.1016/j.seppur.2023.126238.

Zhang A, Liang YX, Zhang H, Geng ZG, Zeng J. Doping regulation in transition metal compounds for electrocatalysis. Chem Soc Rev. 2021;50:9817–44. https://doi.org/10.1039/D1CS00330E.

Article  CAS  PubMed  Google Scholar 

Xiao ML, Han DW, Yang XQ, Tchinda NT, Du L, Guo YC, Wei YC, Yu XL, Ge MF. Ni-doping-induced oxygen vacancy in Pt-CeO2 catalyst for toluene oxidation: enhanced catalytic activity, water-resistance, and SO2-tolerance. Appl Catal B-Environ. 2023;323. https://doi.org/10.1016/j.apcatb.2022.122173.

Niu X, Pei WY, Ma JF. Medium entropy FeCoNi nanoalloy supported on reduced graphene oxide for efficient electrochemical detection of roxarsone in food samples. Food Chem. 2024;455. https://doi.org/10.1016/j.foodchem.2024.139918.

Li W, Cai T, Tian J, Dong Y, Hu F, Peng H. Medium entropy-derived flower-like FeCeCu nanozyme with excellent oxidase-like activity for on-site and visual detection of carbosulfan. Anal Chim Acta. 2025;1337:343566. https://doi.org/10.1016/j.aca.2024.343566.

Article  CAS  PubMed  Google Scholar 

Wu H, Wang ZC, Li ZX, Ma YJ, Ding F, Li FQ, Bian HF, Zhai QX, Ren YL, Shi YX, Yang YR, Deng Y, Tang SC, Meng XK. Medium-entropy metal selenides nanoparticles with optimized electronic structure as high-performance bifunctional electrocatalysts for overall water splitting. Adv Energy Mater. 2023;13. https://doi.org/10.1002/aenm.202300837.

Yang YY, Tan XL, Wang YR, Shen BX, Yang YQ, Huang H. Heteroatom-doped nanozyme progress and perspectives: from synthesis strategies to biomedical applications. Chem Eng J. 2023;468. https://doi.org/10.1016/j.cej.2023.143703.

Chang L, Jing HC, Liu C, Qiu CT, Ling X. High-entropy materials for prospective biomedical applications: challenges and opportunities. Adv Sci. 2024;11. https://doi.org/10.1002/advs.202406521.

An N, Sun YN, Gao L, Wu YD, Xue JN, Li ZR, Hui XD. Long-term structural stability and excellent mechanical properties of CoCrNi system medium entropy alloys. J Alloy Compd. 2022;914:165206. https://doi.org/10.1016/j.jallcom.2022.165206.

Article  CAS  Google Scholar 

Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 2012;8(9):1237.

CAS  PubMed  PubMed Central  Google Scholar 

Yang PH, Zhao YZ, Li J, Liu CY, Zhu LN, Zhang J, Yu YY, Wang WJ, Lei GL, Yan J, Sun F, Bian CR, Meng FP, Xu Z, Bai CQ, Ye BW, Guo YY, Shu LM, Yuan XJ, Zhang N, Bi YH, Shi Y, Wu GZ, Zhang SG, Gao GRF, Liu LQ, Liu WJ, Sun HX. Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients. Cell Mol Immunol. 2021;18:1064–6. https://doi.org/10.1038/s41423-021-00652-5.

Article  CAS  PubMed  Google Scholar 

Picod A, Morisson L, de Roquetaillade C, Sadoune M, Mebazaa A, Gayat E, Davison BA, Cotter G, Chousterman BG. Systemic inflammation evaluated by interleukin-6 or C-reactive protein in critically ill patients: results from the FROG-ICU study. Front Immunol. 2022;13:868348. https://doi.org/10.3389/fimmu.2022.868348.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gairing SJ, Anders J, Kaps L, Nagel M, Michel M, Kremer WM, Hilscher M, Galle PR, Schattenberg JM, Wörns MA, Labenz C. Evaluation of IL-6 for stepwise diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. Hepatol Commun. 2022;6(5):1113–22. https://doi.org/10.1002/hep4.1883.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Rong L, Cui R, Feng J, Jin Y, Yu Y, Chen X, Xu R. Dynamic changes in serum IL-6, IL-8, and IL-10 predict the outcome of ICU patients with severe COVID-19. Ann Palliat Med. 2021;10(4):3706–3714. https://doi.org/10.21037/apm-20-2134

Armstrong EJ, Morrow DA, Sabatine MS. Inflammatory biomarkers in acute coronary syndromes: Part I: Introduction and cytokines. Circulation. 2006;113(6):e72–5. https://doi.org/10.1161/CIRCULATIONAHA.105.595520.

Article  PubMed  Google Scholar 

de Gonzalo-Calvo D, Neitzert K, Fernández M, Vega-Naredo I, Caballero B, García-Macía M, Suárez MF, Rodríguez-Colunga MJ, Solano JJ, Coto-Montes A. Differential inflammatory responses in aging and disease: TNF-α and IL-6 as possible biomarkers. Free Radical Bio Med. 2010;49(5):733–7. https://doi.org/10.1016/j.freeradbiomed.2010.05.019.

Article  CAS  Google Scholar 

Huang L, Zhao X, Qi Y, Li H, Ye GC, Liu YF, Zhang Y, Gou JJ. Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019. Cell Mol Immunol. 2020;17:1092–4. https://doi.org/10.1038/s41423-020-00522-6.

Article  CAS  PubMed  Google Scholar 

Santa Cruz A, Mendes-Frias A, Oliveira AI, Dias L, Matos AR, Carvalho A, Capela C, Pedrosa J, Castro AG, Silvestre R. Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia. Front Immunol. 2021;12:613422. https://doi.org/10.3389/fimmu.2021.613422.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kusske AM, Rongione AJ, Reber HA. Cytokines and acute pancreatitis. Gastroenterology. 1996;110(2):639–42. https://doi.org/10.1053/gast.1996.v110.agast960639.

Article  CAS  PubMed  Google Scholar 

Chollet-Martin S, Jourdain B, Gibert C, Elbim C, Chastre J, Gougerot-Pocidalo MA. Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. Am J Resp Crit Care. 1996;154(3):594–601. https://doi.org/10.1164/ajrccm.154.3.8810592.

Article  CAS  Google Scholar 

Hun X, Zhang Z. Functionalized fluorescent core-shell nanoparticles used as a fluorescent labels in fluoroimmunoassay for IL-6. Biosens Bioelectron. 2007;22(11):2743–8. https://doi.org/10.1016/j.bios.2007.01.022.

Article  CAS  PubMed  Google Scholar 

Scandurra C, Björkström K, Sarcina L, Imbriano A, Di Franco C, Österbacka R, Bollella P, Scamarcio G, Torsi L, Macchia E. Single molecule with a large transistor-SiMoT cytokine IL-6 detection benchmarked against a chemiluminescent ultrasensitive immunoassay array. Adv Mater Technol. 2023;8(11):2201910. https://doi.org/10.1002/admt.202201910.

Article  CAS  Google Scholar 

De Benedetti F, Massa M, Pignatti P, Albani S, Novick D, Martini A. Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J Clin Invest. 1994;93(5):2114–9. https://doi.org/10.1172/JCI117206.

Article  PubMed  PubMed Central  Google Scholar 

Peng P, Liu C, Li Z, Xue Z, Mao P, Hu J, Xu F, Yao C, You M. Emerging ELISA-derived technologies for in vitro diagnostics. Trac Trend Anal Chem. 2022;152:116605. https://doi.org/10.1016/j.trac.2022.116605.

Article  CAS  Google Scholar 

Majdinasab M, Lamy de la Chapelle M, Marty JL. Recent progresses in optical biosensors for interleukin 6 detection. Biosensors. 2023;13(9):898. https://doi.org/10.3390/bios13090898.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Zhou Y, Chandrawati R. Metal and metal oxide nanoparticles to enhance the performance of enzyme-linked immunosorbent assay (ELISA). ACS Appl Nano Mater. 2019;3(1):1–21. https://doi.org/10.1021/acsanm.9b02003.

Article  CAS  Google Scholar 

Tan Z, Dong H, Liu Q, Liu H, Zhao P, Wang P, Li Y, Zhang D, Zhao Z, Dong Y. A label-free immunosensor based on PtPd NCs@ MoS2 nanoenzymes for hepatitis B surface antigen detection. Biosens Bioelectron. 2019;142:111556. https://doi.org/10.1016/j.bios.2019.111556.

Article  CAS  PubMed  Google Scholar 

Le Pottier L, Bendaoud B, Renaudineau Y, Youinou P, Pers JO, Daridon C. New ELISA for B cell–activating factor. Clin Chem. 2009;55(10):1843–51. https://doi.org/10.1373/clinchem.2009.129940.

Article  CAS  PubMed  Google Scholar 

Lu B, Liu Q, Wang C, Masood Z, Morris DJ, Nichols F, Mercado R, Zhang P, Ge Q, Xin HL, Chen S. Ultrafast preparation of non-equilibrium Fe-Ni spinels by magnetic induction. J Energy Chem. 2021;53:290–302. https://spj.science.org/doi/10.34133/2022/9756983.

Liu H, Zhong Z. Realizing stable electrochemical performance using MnNi2O4 micro/nano mesospheres prepared by self-template route. Int J Hydrogen Energy. 2022;47(11):7379–87. https://doi.org/10.1016/j.ijhydene.2021.12.058.

Article  CAS  Google Scholar 

Jin X, Li Y, Zhang B, Xu X, Sun G, Wang Y. Temperature-dependent dual selectivity of hierarchical porous In2O3 nanospheres for sensing ethanol and TEA. Sensor Actuat B: Chem. 2021;330:129271. https://doi.org/10.1016/j.snb.2020.129271.

Article  CAS  Google Scholar 

Zhang C, Guo Y, Guo Y, Lu G, Boreave A, Retailleau L, Baylet A, Giroir-Fendler A. LaMnO3 perovskite oxides prepared by different methods for catalytic oxidation of toluene. Appl Catal B: Environ. 2014;148:490–8. https://doi.org/10.1016/j.apcatb.2013.11.030.

Article  CAS  Google Scholar 

Zhang H, Yang D, Ma T, Lin H, Jia B. Flash-induced ultrafast production of graphene/MnO with extraordinary supercapacitance. Small Methods. 2021;5(7):2100225. https://doi.org/10.1002/smtd.202100225.