Pietrini D, Piastra M, Luca E, Mancino A, Conti G, Cavaliere F, et al. Neuroprotection and hypothermia in infants and children. Curr Drug Targets. 2012;13:925–35.

Article  CAS  PubMed  Google Scholar 

American Academy of Pediatrics. Committee on Fetus and Newborn, Hypothermia and neonatal encephalopathy. Pediatrics. 2014;133:1146–50. https://doi.org/10.1542/peds.2014-0899

Article  Google Scholar 

Hong SB, Koh Y, Lee IC, Kim MJ, Kim WS, Kim DS, et al. Induced hypothermia as a new approach to lung rest for the acutely injured lung. Crit Care Med. 2005;33:2049–55. https://doi.org/10.1097/01.CCM.0000178186.37167.53

Article  PubMed  Google Scholar 

Huang P-S, Tang G-J, Chen C-H, Kou YR. Whole-body moderate hypothermia confers protection from wood smoke-induced acute lung injury in rats: The therapeutic window. Crit Care Med. 2006;34:1160–7. https://doi.org/10.1097/01.CCM.0000207342.50559.0F

Article  PubMed  Google Scholar 

Ball MK, Hillman NH, Kallapur SG, Polglase GR, Jobe AH, Pillow JJ. Body temperature effects on lung injury in ventilated preterm lambs. Resuscitation. 2010;81:749–54. https://doi.org/10.1016/j.resuscitation.2009.12.007

Article  PubMed  PubMed Central  Google Scholar 

Cruces P, Erranz B, Donoso A, Carvajal C, Salomón T, Torres MF, et al. Mild hypothermia increases pulmonary anti-inflammatory response during protective mechanical ventilation in a piglet model of acute lung injury. Pediatr Anesth. 2013;23:1069–77. https://doi.org/10.1111/pan.12209

Article  Google Scholar 

Angus SA, Henderson WR, Banoei MM, Molgat-Seon Y, Peters CM, Parmar HR, et al. Therapeutic hypothermia attenuates physiologic, histologic, and metabolomic markers of injury in a porcine model of acute respiratory distress syndrome. Physiol Rep. 2022;10:e15286. https://doi.org/10.14814/phy2.15286

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akyol O, Demirgan S, Şengelen A, Güneyli HC, Oran DS, Yıldırım F, et al. Mild Hypothermia via External Cooling Improves Lung Function and Alleviates Pulmonary Inflammatory Response and Damage in Two-Hit Rabbit Model of Acute Lung Injury. J Invest Surg. 2022;35:1472–83. https://doi.org/10.1080/08941939.2022.2064010

Article  PubMed  Google Scholar 

De Luca D, Shankar-Aguilera S, Autilio C, Raschetti R, Vedovelli L, Fitting C, et al. Surfactant-secreted phospholipase A 2 interplay and respiratory outcome in preterm neonates. Am J Physiol Lung Cell Mol Physiol. 2020;319:L95–104. https://doi.org/10.1152/ajplung.00462.2019

Article  CAS  PubMed  Google Scholar 

De Luca D, Vázquez-Sánchez S, Minucci A, Echaide M, Piastra M, Conti G, et al. Effect of whole-body hypothermia on inflammation and surfactant function in asphyxiated neonates. Eur Resp J. 2014;44:1708–10. https://doi.org/10.1183/09031936.00117714

Article  Google Scholar 

Autilio C, Shankar-Aguilera S, Minucci A, Touqui L, De Luca D. Effect of cooling on lung secretory phospholipase A2 activity in vitro, ex vivo, and in vivo. Am J Physiol Lung Cell Mol Physiol. 2019;316:L498–505. https://doi.org/10.1152/ajplung.00201.2018

Article  CAS  PubMed  Google Scholar 

Langman C, Orgeig S, Daniels CB. Alterations in composition and function of surfactant associated with torpor in Sminthopsis crassicaudata. Am J Physiol. 1996;271:R437–45. https://doi.org/10.1152/ajpregu.1996.271.2.R437

Article  CAS  PubMed  Google Scholar 

Suri LN, McCaig L, Picardi MV, Ospina OL, Veldhuizen RA, Staples JF, et al. Adaptation to low body temperature influences pulmonary surfactant composition thereby increasing fluidity while maintaining appropriately ordered membrane structure and surface activity. Biochim Biophys Acta. 2012;1818:1581–9. https://doi.org/10.1016/j.bbamem.2012.02.021

Article  CAS  PubMed  Google Scholar 

Autilio C, Echaide M, Cruz A, García-Mouton C, Hidalgo A, Da Silva E, et al. Molecular and biophysical mechanisms behind the enhancement of lung surfactant function during controlled therapeutic hypothermia. Sci Rep. 2021;11:728. https://doi.org/10.1038/s41598-020-79025-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Autilio C, Echaide M, Dell’Orto V, Perez-Gil J, De Luca D. Effect of Whole Body Hypothermia on Surfactant Function When Amniotic Fluid is Meconium Stained. Ther Hypothermia Temp Manag. 2020;10:186–89. https://doi.org/10.1089/ther.2017.0012

Article  PubMed  Google Scholar 

Autilio C, Echaide M, De Luca D, Perez-Gil J. Controlled hypothermia may improve surfactant function in asphyxiated neonates with or without meconium aspiration syndrome. PLoS One. 2018;13:e0192295. https://doi.org/10.1371/journal.pone.0192295

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nespeca M, Giorgetti C, Nobile S, Ferrini I, Simonato M, Verlato G, et al. Does Whole-Body Hypothermia in Neonates with Hypoxic–Ischemic Encephalopathy Affect Surfactant Disaturated-Phosphatidylcholine Kinetics? PLoS One. 2016;11:e0153328. https://doi.org/10.1371/journal.pone.0153328

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayek AJ, White HD, Ghamande S, Spradley C, Arroliga AC. Is Therapeutic Hypothermia for Acute Respiratory Distress Syndrome the Future? J Intensive Care Med. 2017;32:460–4. https://doi.org/10.1177/0885066617701117

Article  PubMed  Google Scholar 

Pietrini D, Pennisi M, Vitale F, Pulitanò SM, Conti G, Mancino A, et al. Rescue hypothermia for refractory hypercapnia. Eur J Pediatr. 2012;171:1855–7. https://doi.org/10.1007/s00431-012-1769-6

Article  PubMed  Google Scholar 

Cruces P, Cores C, Casanova D, Pizarro F, Diaz F. Successful use of mild therapeutic hypothermia as compassionate treatment for severe refractory hypoxemia in COVID-19. J Crit Care. 2021;63:260–3. https://doi.org/10.1016/j.jcrc.2021.01.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karnatovskaia LV, Festic E, Freeman WD, Lee AS. Effect of Therapeutic Hypothermia on Gas Exchange and Respiratory Mechanics: A Retrospective Cohort Study. Ther Hypothermia Temp Manag. 2014;4:88–95. https://doi.org/10.1089/ther.2014.0004

Article  PubMed  Google Scholar 

Slack DF, Corwin DS, Shah NG, Shanholtz CB, Verceles AC, Netzer G, et al. Pilot Feasibility Study of Therapeutic Hypothermia for Moderate to Severe Acute Respiratory Distress Syndrome. Crit Care Med. 2017;45:1152–9. https://doi.org/10.1097/CCM.0000000000002338

Article  PubMed  PubMed Central  Google Scholar 

Aslami H, Binnekade JM, Horn J, Huissoon S, Juffermans NP. The effect of induced hypothermia on respiratory parameters in mechanically ventilated patients. Resuscitation. 2010;81:1723–5. https://doi.org/10.1016/j.resuscitation.2010.09.006

Article  PubMed  Google Scholar 

De Luca D, Tingay DG, van Kaam A, Brunow de Carvalho W, Valverde E, Christoph Roehr C, et al. Hypothermia and Meconium Aspiration Syndrome: International Multicenter Retrospective Cohort Study. Am J Resp Crit Care Med. 2016;194:381–4. https://doi.org/10.1164/rccm.201602-0422LE

Article  PubMed  Google Scholar 

https://clinicaltrials.gov/study/NCT04545424 n.d. [Accessed on Sept 30, 2024]

De Luca D, Capoluongo E, Rigo V. Study group on Secretory Phospholipase in Paediatrics (SSPP). Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study. BMC Pediatr. 2011;11:101. https://doi.org/10.1186/1471-2431-11-101.

Article  PubMed  PubMed Central  Google Scholar 

Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349–58.

Article  CAS  PubMed  Google Scholar 

De Luca D, Minucci A, Tripodi D, Piastra M, Pietrini D, Zuppi C, et al. Role of distinct phospholipases A2 and their modulators in meconium aspiration syndrome in human neonates. Intensive Care Med. 2011;37:1158–65. https://doi.org/10.1007/s00134-011-2243-z

Article  CAS  PubMed  Google Scholar 

de Blic J, Midulla F, Barbato A, Clement A, Dab I, Eber E, et al. On behalf of the ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. Bronchoalveolar lavage in children. Eur Resp J. 2000;15:217–31. https://doi.org/10.1183/09031936.00.15121700

Article  Google Scholar