Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW (2017) QuPath: open source software for digital pathology image analysis. Sci Rep 7:16878. https://doi.org/10.1038/s41598-017-17204-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowles KR, Pugh DA, Oja L-M, Jadow BM, Farrell K, Whitney K, Sharma A, Cherry JD, Raj T, Pereira AC, Crary JF, Goate AM (2022) Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD. Acta Neuropathol 143:225–243. https://doi.org/10.1007/s00401-021-02392-2

Article  CAS  PubMed  Google Scholar 

Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M (2016) A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation. Proc Natl Acad Sci U S A 113:4753–4758. https://doi.org/10.1073/pnas.1516604113

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conrad C, Andreadis A, Trojanowski JQ, Dickson DW, Kang D, Chen X, Wiederholt W, Hansen L, Masliah E, Thal LJ, Katzman R, Xia Y, Saitoh T (1997) Genetic evidence for the involvement of tau in progressive supranuclear palsy. Ann Neurol 41:277–281. https://doi.org/10.1002/ana.410410222

Article  CAS  PubMed  Google Scholar 

Ezerskiy LA, Schoch KM, Sato C, Beltcheva M, Horie K, Rigo F, Martynowicz R, Karch CM, Bateman RJ, Miller TM (2022) Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction. JCI Insight 7:e152012. https://doi.org/10.1172/jci.insight.152012

Fiock KL, Hook JN, Hefti MM (2023) Determinants of astrocytic pathology in stem cell models of primary tauopathies. Acta Neuropathol Commun 11:161. https://doi.org/10.1186/s40478-023-01655-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forman MS, Lal D, Zhang B, Dabir DV, Swanson E, Lee VM-Y, Trojanowski JQ (2005) Transgenic Mouse Model of Tau Pathology in astrocytes leading to Nervous System Degeneration. J Neurosci 25:3539–3550. https://doi.org/10.1523/JNEUROSCI.0081-05.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forrest SL, Lee S, Nassir N, Martinez-Valbuena I, Sackmann V, Li J, Ahmed A, Tartaglia MC, Ittner LM, Lang AE, Uddin M, Kovacs GG (2023) Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy. Acta Neuropathol 146:395–414. https://doi.org/10.1007/s00401-023-02604-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujita M, Gao Z, Zeng L, McCabe C, White CC, Ng B, Green GS, Rozenblatt-Rosen O, Phillips D, Amir-Zilberstein L, Lee H, Pearse RV, Khan A, Vardarajan BN, Kiryluk K, Ye CJ, Klein H-U, Wang G, Regev A, Habib N, Schneider JA, Wang Y, Young-Pearse T, Mostafavi S, Bennett DA, Menon V, De Jager PL (2024) Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain. Nat Genet 1–10. https://doi.org/10.1038/s41588-024-01685-y

Heckman MG, Brennan RR, Labbé C, Soto AI, Koga S, DeTure MA, Murray ME, Petersen RC, Boeve BF, van Gerpen JA, Uitti RJ, Wszolek ZK, Rademakers R, Dickson DW, Ross OA (2019) Association of MAPT Subhaplotypes with Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology. JAMA Neurol 76:710–717. https://doi.org/10.1001/jamaneurol.2019.0250

Article  PubMed  PubMed Central  Google Scholar 

Ikeda C, Yokota O, Miki T, Takenoshita S, Ishizu H, Terada S, Yamada N (2018) Astrocytic tau pathologies in Argyrophilic Grain Disease and Related four-repeat tauopathies. Acta Med Okayama 72:211–221. https://doi.org/10.18926/AMO/56066

Article  CAS  PubMed  Google Scholar 

Ingelsson M, Ramasamy K, Russ C, Freeman SH, Orne J, Raju S, Matsui T, Growdon JH, Frosch MP, Ghetti B, Brown RH, Irizarry MC, Hyman BT (2007) Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. Acta Neuropathol 114:471–479. https://doi.org/10.1007/s00401-007-0280-z

Article  CAS  PubMed  Google Scholar 

Kovacs GG (2020) Astroglia and Tau: New perspectives. Front Aging Neurosci 12:96. https://doi.org/10.3389/fnagi.2020.00096

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL, Wisniewski T, Woulfe JM, Yamada M, Dickson DW (2016) Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol 131:87–102. https://doi.org/10.1007/s00401-015-1509-x

Article  CAS  PubMed  Google Scholar 

Kovacs GG, Lee VM, Trojanowski JQ (2017) Protein astrogliopathies in human neurodegenerative diseases and aging: protein astrogliopathies. Brain Pathol 27:675–690. https://doi.org/10.1111/bpa.12536

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM-Y, Trojanowski JQ, Höglinger GU (2020) Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathol 140:99–119. https://doi.org/10.1007/s00401-020-02158-2

Article  PubMed  PubMed Central  Google Scholar 

Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M (2017) Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease. Proc Natl Acad Sci U S A 114:E5703–E5711. https://doi.org/10.1073/pnas.1618417114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT, National Institute on Aging, Alzheimer’s Association (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123:1–11. https://doi.org/10.1007/s00401-011-0910-3

Article  CAS  PubMed  Google Scholar 

Mummery CJ, Börjesson-Hanson A, Blackburn DJ, Vijverberg EGB, De Deyn PP, Ducharme S, Jonsson M, Schneider A, Rinne JO, Ludolph AC, Bodenschatz R, Kordasiewicz H, Swayze EE, Fitzsimmons B, Mignon L, Moore KM, Yun C, Baumann T, Li D, Norris DA, Crean R, Graham DL, Huang E, Ratti E, Bennett CF, Junge C, Lane RM (2023) Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial. Nat Med 29:1437–1447. https://doi.org/10.1038/s41591-023-02326-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nolan A, De Paula Franca Resende E, Petersen C, Neylan K, Spina S, Huang E, Seeley W, Miller Z, Grinberg LT (2019) Astrocytic tau deposition is frequent in typical and atypical Alzheimer Disease presentations. J Neuropathol Exp Neurol 78:1112–1123. https://doi.org/10.1093/jnen/nlz094

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT (2020) Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathol Commun 8:168. https://doi.org/10.1186/s40478-020-01049-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin L-C, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH (2023) Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics. bioRxiv 2023.09.29.560245. https://doi.org/10.1101/2023.09.29.560245

Roemer SF, Grinberg LT, Crary JF, Seeley WW, McKee AC, Kovacs GG, Beach TG, Duyckaerts C, Ferrer IA, Gelpi E, Lee EB, Revesz T, White CL, Yoshida M, Pereira FL, Whitney K, Ghayal NB, Dickson DW (2022) Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy. Acta Neuropathol 144:603–614. https://doi.org/10.1007/s00401-022-02479-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Secci ME, Reed T, Quinlan V, Gilpin NW, Avegno EM (2023) Quantitative analysis of Gene expression in RNAscope-processed brain tissue. Bio Protoc 13:e4580. https://doi.org/10.21769/BioProtoc.4580

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simone R, Javad F, Emmett W, Wilkins OG, Almeida FL, Barahona-Torres N, Zareba-Paslawska J, Ehteramyan M, Zuccotti P, Modelska A, Siva K, Virdi GS, Mitchell JS, Harley J, Kay VA, Hondhamuni G, Trabzuni D, Ryten M, Wray S, Preza E, Kia DA, Pittman A, Ferrari R, Manzoni C, Lees A, Hardy JA, Denti MA, Quattrone A, Patani R, Svenningsson P, Warner TT, Plagnol V, Ule J, de Silva R (2021) MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration. Nature 594:117–123. https://doi.org/10.1038/s41586-021-03556-6