Reithinger R, Dujardin JC, Louzir H et al (2007) Cutaneous leishmaniasis. Lancet Infect Dis 7:581–596. https://doi.org/10.1016/S1473-3099(07)70209-8

Article  PubMed  Google Scholar 

Volpedo G, Pacheco-Fernandez T, Holcomb EA et al (2021) Mechanisms of immunopathogenesis in cutaneous leishmaniasis and post kala-azar dermal leishmaniasis (PKDL). Front Cell Infect Microbiol 11:1–16. https://doi.org/10.3389/fcimb.2021.685296

Article  CAS  Google Scholar 

Knowles AF (2011) The GDA1_CD39 superfamily: NTPDases with diverse functions. Purinergic Signal 7:21–45. https://doi.org/10.1007/s11302-010-9214-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zimmermann H (2000) Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 362:299–309. https://doi.org/10.1007/s002100000309

Article  CAS  PubMed  Google Scholar 

Robson SC, Sévigny J, Zimmermann H (2006) The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance. Purinergic Signal 2:409–430. https://doi.org/10.1007/s11302-006-9003-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zimmermann H, Zebisch M, Sträter N (2012) Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal 8:437–502. https://doi.org/10.1007/s11302-012-9309-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao W, Fang F, Gould T et al (2020) Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. J Clin Invest 130:3422–3436. https://doi.org/10.1172/JCI132417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corriden R, Chen Y, Inoue Y et al (2008) Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem 283:28480–28486. https://doi.org/10.1074/jbc.M800039200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jhandier MN, Kruglov EA, Lavoie ÉG et al (2005) Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2. J Biol Chem 280:22986–22992. https://doi.org/10.1074/jbc.M412371200

Article  CAS  PubMed  Google Scholar 

Langston HP, Ke Y, Gewirtz AT et al (2003) Secretion of IL-2 and IFN- γ , But Not IL-4, by antigen-specific T cells requires extracellular ATP. J Immunol 170:2962–2970. https://doi.org/10.4049/jimmunol.170.6.2962

Article  CAS  PubMed  Google Scholar 

Marcus AJ, Broekman MJ, Drosopoulos JHF et al (1997) The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest 99:1351–1360. https://doi.org/10.1172/JCI119294

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leite PM, Gomes RS, Figueiredo AB et al (2012) Ecto-nucleotidase activities of promastigotes from Leishmania ( Viannia ) braziliensis relates to parasite infectivity and disease clinical outcome. PLoS Negl Trop Dis 6:e1850. https://doi.org/10.1371/journal.pntd.0001850

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asai T, O’Sullivan JW, Tatibana M (1983) A potent nucleoside triphosphate hydrolase from the parasitic protozoan Toxoplasma gondii. J Biol Chem 258:6816–6822

Article  CAS  PubMed  Google Scholar 

Asai T, Miura S, Sibley LD et al (1995) Biochemical and molecular characterization of nucleoside triphosphate hydrolase isozymes from the parasitic protozoan Toxoplasma gondii. J Biol Chem 270:11391–11397. https://doi.org/10.1074/jbc.270.19.11391

Article  CAS  PubMed  Google Scholar 

Vasconcelos EG, Ferreira ST, De Carvalho TMU et al (1996) Partial purification and immunohistochemical localization of ATP diphosphohydrolase from Schistosoma mansoni: Immunological cross-reactivities with potato apyrase and Toxoplasma gondii nucleoside triphosphate hydrolase. J Biol Chem 271:22139–22145. https://doi.org/10.1074/jbc.271.36.22139

Article  CAS  PubMed  Google Scholar 

Berrêdo-Pinho M, Peres-Sampaio CE, Chrispim PPM et al (2001) A mg-dependent ecto-ATPase in Leishmania amazonensis and its possible role in adenosine acquisition and virulence. Arch Biochem Biophys 391:16–24. https://doi.org/10.1006/abbi.2001.2384

Article  CAS  PubMed  Google Scholar 

Pinheiro CM, Martins-Duarte ES, Ferraro RB et al (2006) Leishmania amazonensis: biological and biochemical characterization of ecto-nucleoside triphosphate diphosphohydrolase activities. Exp Parasitol 114:16–25. https://doi.org/10.1016/j.exppara.2006.02.007

Article  CAS  PubMed  Google Scholar 

Paes-Vieira L, Rocco-Machado N, Freitas-Mesquita AL et al (2021) Differential regulation of E-NTPdases during Leishmania amazonensis lifecycle and effect of their overexpression on parasite infectivity and virulence. Parasitol Int 85:102423. https://doi.org/10.1016/j.parint.2021.102423

Article  CAS  PubMed  Google Scholar 

Fietto JLR, DeMarco R, Nascimento IP et al (2004) Characterization and immunolocalization of an NTP diphosphohydrolase of Trypanosoma cruzi. Biochem Biophys Res Commun 316:454–460. https://doi.org/10.1016/j.bbrc.2004.02.071

Article  CAS  PubMed  Google Scholar 

Mariotini-Moura C, Bastos MS, de Castro FF et al (2014) Trypanosoma cruzi nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase-1) biochemical characterization, immunolocalization and possible role in host cell adhesion. Acta Trop 130:140–147. https://doi.org/10.1016/j.actatropica.2013.11.008

Article  CAS  PubMed  Google Scholar 

Rezende-Soares FA, Carvalho-Campos C, Marques MJ et al (2010) Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform. Parasitology 137:773–783. https://doi.org/10.1017/S0031182009991661

Article  CAS  PubMed  Google Scholar 

Porcino GN, Carvalho-Campos C, Maia ACRG et al (2012) Leishmania (Viannia) braziliensis nucleoside triphosphate diphosphohydrolase (NTPDase 1): localization and in vitro inhibition of promastigotes growth by polyclonal antibodies. Exp Parasitol 132:293–299. https://doi.org/10.1016/j.exppara.2012.08.009

Article  CAS  PubMed  Google Scholar 

Vasconcellos RDS, Mariotini-Moura C, Gomes RS et al (2014) Leishmania infantum ecto-nucleoside triphosphate diphosphohydrolase-2 is an apyrase involved in macrophage infection and expressed in infected dogs. PLoS Negl Trop Dis 8:e3309. https://doi.org/10.1371/journal.pntd.0003309

Article  PubMed  PubMed Central  Google Scholar 

Sansom FM, Ralton JE, Sernee MF et al (2014) Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence. PLoS Negl Trop Dis 8:e3402. https://doi.org/10.1371/journal.pntd.0003402

Article  PubMed  PubMed Central  Google Scholar 

Borges-Pereira L, Meissner KA, Wrenger C, Garcia CRS (2017) Plasmodium falciparum GFP-E-NTPDase expression at the intraerythrocytic stages and its inhibition blocks the development of the human malaria parasite. Purinergic Signal 13:267–277. https://doi.org/10.1007/s11302-017-9557-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bisaggio DFR, Peres-Sampaio CE, Meyer-Fernandes JR, Souto-Padrón T (2003) Ecto-ATPase activity on the surface of Trypanosoma cruzi and its possible role in the parasite-host cell interaction. Parasitol Res 91:273–282. https://doi.org/10.1007/s00436-003-0965-8

Article  PubMed  Google Scholar 

Maioli T, Takane EMR, Arantes E et al (2004) Immune response induced by New World Leishmania species in C57BL / 6 mice. Parasitol Res 94:207–212. https://doi.org/10.1007/s00436-004-1193-6

Article  PubMed  Google Scholar 

Marques-da-silva EDA, Camargos J, Oliveira D, Afonso C (2008) Extracellular nucleotide metabolism in Leishmania: influence of adenosine in the establishment of infection. Microbes Infect 10:850–857. https://doi.org/10.1016/j.micinf.2008.04.016

Article  CAS  Google Scholar 

Gomes RS, de Carvalho LCF, de Souza VR et al (2015) E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazonensis inhibits macrophage activation. Microbes Infect 17:295–303. https://doi.org/10.1016/j.micinf.2014.12.009

Article  CAS  PubMed  Google Scholar 

Detoni ML, Fessel MR, Maia ACRG et al (2013) An antigenic domain of the Leishmania amazonensis nucleoside triphosphate diphosphohydrolase (NTPDase 1) is associated with disease progression in susceptible infected mice. Parasitol Res 112:2773–2782. https://doi.org/10.1007/s00436-013-3445-9

Article  CAS  PubMed  Google Scholar 

Maia ACRG, Porcino GN, Detoni ML et al (2019) Leishmania infantum amastigote nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1): its inhibition as a new insight into mode of action of pentamidine. Exp Parasitol 200:1–6. https://doi.org/10.1016/j.exppara.2019.03.003

Article  CAS  PubMed  Google Scholar 

da Silva W, da Rocha TN, de Melo AJ et al (2020) ENTPDases from pathogenic trypanosomatids and purinergic signaling: shedding light towards biotechnological applications. Curr Top Med Chem 21:213–226. https://doi.org/10.2174/1568026620666201005125146

Article  CAS