P2X7 receptors: a bibliometric review from 2002 to 2023

Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 Receptor in Infection and Inflammation. Immunity 47:15–31. https://doi.org/10.1016/j.immuni.2017.06.020

Article  CAS  PubMed  Google Scholar 

Burnstock G, Knight GE (2018) The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression. Purinergic Signal 14:1–18. https://doi.org/10.1007/s11302-017-9593-0

Article  CAS  PubMed  Google Scholar 

Illes P, Mueller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ et al (2021) Update of P2X receptor properties and their pharmacology: IUPHAR Review 30. Br J Pharmacol 178:489–514. https://doi.org/10.1111/bph.15299

Article  CAS  PubMed  Google Scholar 

Csoka B, Nemeth ZH, Toero G, Idzko M, Zech A, Koscso B et al (2015) Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing. FASEB J 29:3626–3637. https://doi.org/10.1096/fj.15-272450

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E (2016) Neutrophil P2X<sub>7</sub> receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat Commun 7. https://doi.org/10.1038/ncomms10555

Zhao Y-F, Tang Y, Illes P (2021) Astrocytic and Oligodendrocytic P2X7 Receptors Determine Neuronal Functions in the CNS. Front Molec Neurosci 14. https://doi.org/10.3389/fnmol.2021.641570

Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, et al (2018) Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. eLife 7. https://doi.org/10.7554/eLife.36217

Song X-m, Xu X-h, Zhu J, Guo Z, Li J, He C et al (2015) Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury. Purinergic Signal 11:203–213. https://doi.org/10.1007/s11302-015-9445-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evangelinellis MM, Souza RF, Mendes CE, Castelucci P (2022) Effects of a P2X7 receptor antagonist on myenteric neurons in the distal colon of an experimental rat model of ulcerative colitis. Histochem Cell Biol 157:65–81. https://doi.org/10.1007/s00418-021-02039-z

Article  CAS  PubMed  Google Scholar 

Machado FA, Souza RF, Figliuolo VR, Coutinho-Silva R, Castelucci P (2023) Effects of experimental ulcerative colitis on myenteric neurons in P2X7-knockout mice. Histochem Cell Biol 160:321–339. https://doi.org/10.1007/s00418-023-02208-2

Article  CAS  PubMed  Google Scholar 

Magalhaes HIR, Machado FA, Souza RF, Caetano MAF, Figliuolo VR, Coutinho-Silva R et al (2023) Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis. World J Gastroenterol 29:3440–3468. https://doi.org/10.3748/wjg.v29.i22.3440

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hattori M, Gouaux E (2012) Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature 485:207-U91. https://doi.org/10.1038/nature11010

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Andrejew R, Oliveira-Giacomelli A, Ribeiro DE, Glaser T, Arnaud-Sampaio VF, Lameu C, et al (2020) The P2X7 receptor: central hub of brain diseases. Front Molec Neurosci 13. https://doi.org/10.3389/fnmol.2020.00124

Cevoli F, Arnould B, Peralta FA, Grutter T (2023) Untangling macropore formation and current facilitation in P2X7. Int J Mol Sci 24. https://doi.org/10.3390/ijms241310896

Kopp R, Krautloher A, Ramirez-Fernandez A, Nicke A (2019) P2X7 Interactions and signaling - making head or tail of it. Front Molec Neurosci 12. https://doi.org/10.3389/fnmol.2019.00183

Linden J, Koch-Nolte F, Dahl G (2019) Purine release, metabolism, and signaling in the inflammatory response. Ann Rev Immunol 37:325–347

Article  CAS  Google Scholar 

Diezmos EF, Bertrand PP, Liu L (2016) Purinergic signaling in gut inflammation: the role of connexins and pannexins. Front Neurosci 10. https://doi.org/10.3389/fnins.2016.00311

Wiley JS, Sluyter R, Gu BJ, Stokes L, Fuller SJ (2011) The human P2X7 receptor and its role in innate immunity. Tissue Antigens 78:321–32. https://doi.org/10.1111/j.1399-0039.2011.01780.x

Article  CAS  PubMed  Google Scholar 

Zhang WJ, Zhu ZM, Liu ZX (2020) The role and pharmacological properties of the P2X7 receptor in neuropathic pain. Brain Res Bull 155:19–28. https://doi.org/10.1016/j.brainresbull.2019.11.006

Article  CAS  PubMed  Google Scholar 

Young CNJ, Gorecki DC (2018) P2RX7 purinoceptor as a therapeutic target-the second coming? Front Chem 6. https://doi.org/10.3389/fchem.2018.00248

Gutierrez-Martin Y, Bustillo D, Gomez-Villafuertes R, Sanchez-Nogueiro J, Torregrosa-Hetland C, Binz T et al (2011) P2X7 receptors trigger ATP exocytosis and modify secretory vesicle dynamics in neuroblastoma cells. J Biol Chem 286:11370–81. https://doi.org/10.1074/jbc.M110.139410

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vargas-Martinez EM, Gomez-Coronado KS, Espinosa-Luna R, Valdez-Morales EE, Barrios-Garcia T, Barajas-Espinosa A, et al (2020) Functional expression of P2X1, P2X4 and P2X7 purinergic receptors in human monocyte-derived macrophages. Eur J Pharmacol 888. https://doi.org/10.1016/j.ejphar.2020.173460

Rivas-Yanez E, Barrera-Avalos C, Parra-Tello B, Briceno P, Rosemblatt MV, Saavedra-Almarza J, et al (2020) P2X7 Receptor at the crossroads of T cell fate. Int J Mol Sci 21. https://doi.org/10.3390/ijms21144937

Jiang L-H, Caseley EA, Muench SP, Roger S (2021) Structural basis for the functional properties of the P2X7 receptor for extracellular ATP. Purinergic Signal 17:331–44. https://doi.org/10.1007/s11302-021-09790-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burnstock G, Jacobson KA, Christofi FL (2017) Purinergic drug targets for gastrointestinal disorders. Curr Opin Pharmacol 37:131–41. https://doi.org/10.1016/j.coph.2017.10.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pegoraro A, De Marchi E, Adinolfi E (2021) P2X7 Variants in oncogenesis. Cells 10. https://doi.org/10.3390/cells10010189

Shokoples BG, Paradis P, Schiffrin EL (2021) P2X7 receptors: an untapped target for the management of cardiovascular disease. Arterioscler Thromb Vasc Biol 41:186–99. https://doi.org/10.1161/ATVBAHA.120.315116

Article  CAS  PubMed  Google Scholar 

Wang DW, Wang H, Gao HX, Zhang H, Zhang H, Wang QL, et al (2020) P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes. Cell Biosci 10. https://doi.org/10.1186/s13578-020-00388-1

Zelentsova AS, Deykin AV, Soldatov VO, Ulezko AA, Borisova AY, Belyaeva VS, et al (2022) P2X7 receptor and purinergic signaling: orchestrating mitochondrial dysfunction in neurodegenerative diseases. eNeuro 9. https://doi.org/10.1523/ENEURO.0092-22.2022

He SY, Zhao Y, Fan YS, Zhao X, Yu J, Xie J, et al (2019) Research trends and hotspots analysis related to monocarboxylate transporter 1: a study based on bibliometric analysis. Int J Environ Res Public Health 16. https://doi.org/10.3390/ijerph16071091

Zhu H, Zhang YG, Feng S, Li YA, Ye YZ, Jian ZH et al (2023) Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: a bibliometric analysis. CNS Neurosci Ther. https://doi.org/10.1111/cns.14232

Article  PubMed  PubMed Central  Google Scholar 

Skaper SD, Debetto P, Giusti P (2010) The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB J 24:337–45. https://doi.org/10.1096/fj.09-138883

Article  CAS  PubMed  Google Scholar 

Adinolfi E, Giuliani AL, De Marchi E, Pegoraro A, Orioli E, Di Virgilio F (2018) The P2X7 receptor: a main player in inflammation. Biochem Pharmacol 151:234–44. https://doi.org/10.1016/j.bcp.2017.12.021

Article  CAS  PubMed  Google Scholar 

Savio LEB, Mello PD, da Silva CG, Coutinho-Silva R (2018) The P2X7 receptor in inflammatory diseases: angel or demon? Front Pharmacol 9. https://doi.org/10.3389/fphar.2018.00052

Sperlagh B, Illes P (2014) P2X7 receptor: an emerging target in central nervous system diseases. Trends Pharmacol Sci 35:537–47. https://doi.org/10.1016/j.tips.2014.08.002

Article  CAS  PubMed  Google Scholar 

Di Virgilio F, Sarti AC, Falzoni S, De Marchi E, Adinolfi E (2018) Extracellular ATP and P2 purinergic signalling in the tumour microenvironment. Nat Rev Cancer 18:601–18. https://doi.org/10.1038/s41568-018-0037-0

Article  CAS  PubMed  Google Scholar 

Bartlett R, Stokes L, Sluyter R (2014) The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease. Pharmacol Rev 66:638–75. https://doi.org/10.1124/pr.113.008003

Article  CAS  PubMed  Google Scholar 

Di Virgilio F, Schmalzing G, Markwardt F (2018) The elusive P2X7 macropore. Trends Cell Biol 28:392–404. https://doi.org/10.1016/j.tcb.2018.01.005

Article  CAS  PubMed  Google Scholar 

McCarthy AE, Yoshioka C, Mansoor SE (2019) Full-Length P2X(7) structures reveal how palmitoylation prevents channel desensitization. Cell 179:659-+. https://doi.org/10.1016/j.cell.2019.09.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Illes P, Muller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ et al (2021) Update of P2X receptor properties and their pharmacology: IUPHAR review 30. Br J Pharmacol 178:489–514. https://doi.org/10.1111/bph.15299

Article  CAS  PubMed  Google Scholar 

De Marchi E, Orioli E, Pegoraro A, Sangaletti S, Portararo P, Curti A et al (2019) The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment. Oncogene 38:3636–50. https://doi.org/10.1038/s41388-019-0684-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gorji A (2022) Neuroinflammation: the pathogenic mechanism of neurological disorders. Int J Mol Sci 23. https://doi.org/10.3390/ijms23105744

Lyman M, Lloyd DG, Ji XM, Vizcaychipi MP, Ma DQ (2014) Neuroinflammation: the role and consequences. Neurosci Res 79:1–12. https://doi.org/10.1016/j.neures.2013.10.004

Article  CAS  PubMed  Google Scholar 

Huang C, Chi XS, Li R, Hu X, Xu HX, Li JM et al (2017) Inhibition of P2X7 receptor ameliorates nuclear factor-Kappa B mediated neuroinflammation induced by status epilepticus in rat hippocampus. J Mol Neurosci 63:173–84. https://doi.org/10.1007/s12031-017-0968-z

Article 

Comments (0)

No login
gif