Kaur J, Dora S (2023) Purinergic signaling: diverse effects and therapeutic potential in cancer. Front Oncol 13:1058371
Article CAS PubMed PubMed Central Google Scholar
Di Virgilio F, Adinolfi E (2017) Extracellular purines, purinergic receptors and tumor growth. Oncogene 36(3):293–303
Di Virgilio F, Sarti AC, Falzoni S, De Marchi E, Adinolfi E (2018) Extracellular ATP and P2 purinergic signalling in the tumour microenvironment. Nat Rev Cancer 18(10):601–618
von Kügelgen I (2021) Molecular pharmacology of P2Y receptor subtypes. Biochem Pharmacol 187:114361
Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V, Di Virgilio F (2008) Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. PLoS ONE 3(7):e2599
Article PubMed PubMed Central ADS Google Scholar
Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK et al (2002) Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 110(7):993–1002
Article CAS PubMed PubMed Central Google Scholar
Poth JM, Brodsky K, Ehrentraut H, Grenz A, Eltzschig HK (2013) Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease. J Mol Med (Berl) 91(2):183–193
Article CAS PubMed Google Scholar
Hatfield SM, , Kjaergaard J, Lukashev D, Schreiber TH, Belikoff B, Abbott R et al (2015) Immunological mechanisms of the antitumor effects of supplemental oxygenation. Sci Transl Med 7(277):277ra30
Article CAS PubMed PubMed Central Google Scholar
Sitkovsky MV, Hatfield S, Abbott R, Belikoff B, Lukashev D, Ohta A (2014) Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists. Cancer Immunol Res 2(7):598–605
Article CAS PubMed PubMed Central Google Scholar
Eltzschig HK, Sitkovsky MV, Robson SC (2012) Purinergic signaling during inflammation. N Engl J Med 367(24):2322–2333
Article CAS PubMed PubMed Central Google Scholar
Longhi MS, Moss A, Jiang ZG, Robson SC (2017) Purinergic signaling during intestinal inflammation. J Mol Med (Berl) 95(9):915–925
Article CAS PubMed Google Scholar
Allard B, Longhi MS, Robson SC, Stagg J (2017) The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev 276(1):121–144
Article CAS PubMed PubMed Central Google Scholar
Nascimento DC, Viacava PR, Ferreira RG, Damaceno MA, Piñeros AR, Melo PH et al (2021) Sepsis expands a CD39<sup>+</sup> plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity. Immunity 54(9):2024–41.e8
Article CAS PubMed Google Scholar
Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC (2017) Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight 2(9):e92791. https://doi.org/10.1172/jci.insight.92791
Article PubMed PubMed Central Google Scholar
Pulte D, Furman RR, Broekman MJ, Drosopoulos JH, Ballard HS, Olson KE et al (2011) CD39 expression on T lymphocytes correlates with severity of disease in patients with chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk 11(4):367–372
Article CAS PubMed PubMed Central Google Scholar
Salvestrini V, Zini R, Rossi L, Gulinelli S, Manfredini R, Bianchi E et al (2012) Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice. Blood 119(1):217–226
Article CAS PubMed Google Scholar
Thapa A, Abdelbaset-Ismail A, Chumak V, Adamiak M, Brzezniakiewicz-Janus K, Ratajczak J et al (2022) Extracellular adenosine (eAdo) - A(2B) receptor axis inhibits in Nlrp3 inflammasome-dependent manner trafficking of hematopoietic stem/progenitor cells. Stem Cell Rev Rep 18(8):2893–2911
Article CAS PubMed PubMed Central Google Scholar
Grassi F, De Ponte CB (2021) The P2X7 Receptor in tumor immunity. Front Cell Dev Biol 9:694831
Article PubMed PubMed Central Google Scholar
He X, Zhang Y, Xu Y, Xie L, Yu Z, Zheng J (2021) Function of the P2X7 receptor in hematopoiesis and leukemogenesis. Exp Hematol 104:40–47
Article CAS PubMed Google Scholar
Salvestrini V, Orecchioni S, Talarico G, Reggiani F, Mazzetti C, Bertolini F et al (2017) Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells. Oncotarget 8(4):5895–5908
Feng W, Yang F, Wang R, Yang X, Wang L, Chen C et al (2016) High level P2X7-mediated signaling impairs function of hematopoietic stem/progenitor cells. Stem Cell Rev Rep 12(3):305–314
Article CAS PubMed Google Scholar
Bujko K, Adamiak M, Abdelbaset-Ismail A, Thapa A, Ilowska N, Ratajczak J et al (2022) Novel evidence that the P2X1 purinergic receptor-Nlrp3 inflammasome axis orchestrates optimal trafficking of hematopoietic stem progenitors cells. Folia Histochem Cytobiol 60(3):280–290
Article CAS PubMed Google Scholar
He X, Xu Y, Huang D, Yu Z, Yu J, Xie L et al (2023) P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways. Leukemia 37(2):265–275
Article CAS PubMed Google Scholar
Saffioti NA, Alvarez CL, Bazzi Z, Gentilini MV, Gondolesi GE, Schwarzbaum PJ et al (2023) Dynamic recycling of extracellular ATP in human epithelial intestinal cells. PLoS Comput Biol 19(6):e1011196
Article CAS PubMed PubMed Central ADS Google Scholar
Lara R, Adinolfi E, Harwood CA, Philpott M, Barden JA, Di Virgilio F et al (2020) P2X7 in cancer: from molecular mechanisms to therapeutics. Front Pharmacol 11:793
Article CAS PubMed PubMed Central Google Scholar
Hevia MJ, Castro P, Pinto K, Reyna-Jeldes M, Rodríguez-Tirado F, Robles-Planells C et al (2019) Differential effects of purinergic signaling in gastric cancer-derived cells through P2Y and P2X receptors. Front Pharmacol 10:612
Article CAS PubMed PubMed Central Google Scholar
Sak K, Boeynaems JM, Everaus H (2003) Involvement of P2Y receptors in the differentiation of haematopoietic cells. J Leukoc Biol 73(4):442–447
Article CAS PubMed Google Scholar
Zhou Y, Arredondo HM, Wang N (2021) P2Y Receptors in bone—anabolic, catabolic, or both? Front Endocrinol (Lausanne) 12:818499
Janho Dit Hreich S, Hofman P, Vouret-Craviari V (2023) The role of IL-18 in P2RX7-mediated antitumor immunity. Int J Mol Sci 24(11):9235. https://doi.org/10.3390/ijms24119235
Article CAS PubMed PubMed Central Google Scholar
Lecciso M, Ocadlikova D, Sangaletti S, Trabanelli S, De Marchi E, Orioli E et al (2017) ATP release from chemotherapy-treated dying leukemia cells elicits an immune suppressive effect by increasing regulatory T cells and tolerogenic dendritic cells. Front Immunol 8:1918
Article PubMed PubMed Central Google Scholar
Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C et al (2009) Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 15(10):1170–1178
Article CAS PubMed Google Scholar
Aymeric L, Apetoh L, Ghiringhelli F, Tesniere A, Martins I, Kroemer G et al (2010) Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity. Cancer Res 70(3):855–858
Article CAS PubMed Google Scholar
De Salis SKF, Li L, Chen Z, Lam KW, Skarratt KK, Balle T, Fuller SJ (2022) Alternatively Spliced Isoforms of the P2X7 Receptor: Structure, Function and Disease Associations. Int J Mol Sci 23(15):8174. https://doi.org/10.3390/ijms23158174
Article CAS PubMed PubMed Central Google Scholar
Chong JH, Zheng GG, Zhu XF, Guo Y, Wang L, Ma CH et al (2010) Abnormal expression of P2X family receptors in Chinese pediatric acute leukemias. Biochem Biophys Res Commun 391(1):498–504
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