Saginala K, Barsouk A, Aluru JS et al (2020) Epidemiology of Bladder Cancer. Med Sci (Basel) 8. https://doi.org/10.3390/medsci8010015

Kogevinas M, Mannetje ’T, Cordier A S, et al (2003) Occupation and Bladder cancer among men in Western Europe. Cancer Causes Control 14:907–914. https://doi.org/10.1023/B:CACO.0000007962.19066.9c

Article  PubMed  Google Scholar 

Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424. https://doi.org/10.3322/caac.21492

Article  PubMed  Google Scholar 

Mushtaq J, Thurairaja R, Nair R (2019) Bladder cancer. Surg (United Kingdom) 37:529–537. https://doi.org/10.1016/j.mpsur.2019.07.003

Article  Google Scholar 

Bellmunt J, Orsola A, Leow JJ et al (2014) Bladder cancer: ESMO practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 25:iii40–iii48. https://doi.org/10.1093/annonc/mdu223

Article  PubMed  Google Scholar 

DeGeorge KC, Holt HR, Hodges SC (2017) Bladder Cancer: diagnosis and treatment. Am Fam Physician 96:507–514

PubMed  Google Scholar 

Lotan Y, Kamat AM, Porter MP et al (2009) Key concerns about the current state of Bladder cancer: a position paper from the Bladder Cancer think Tank, the Bladder Cancer Advocacy Network, and the Society of Urologic Oncology. Cancer 115:4096–4103. https://doi.org/10.1002/cncr.24463

Article  PubMed  Google Scholar 

Chang SS, Bochner BH, Chou R et al (2017) Treatment of non-metastatic muscle-invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline. J Urol 198:552–559. https://doi.org/10.1016/j.juro.2017.04.086

Article  PubMed Central  PubMed  Google Scholar 

Martinez Rodriguez RH, Buisan Rueda O, Ibarz L (2017) Bladder cancer: Present and future. Med Clin (Barc) 149:449–455. https://doi.org/10.1016/j.medcli.2017.06.009

Article  PubMed  Google Scholar 

Dias A, de Scholl F, Moritz JN CEJ, et al (2021) New insights into cytotoxic mechanisms of bozepinib against glioblastoma. Eur J Pharm Sci 162. https://doi.org/10.1016/j.ejps.2021.105823

Ramírez A, Boulaiz H, Morata-Tarifa C et al (2014) HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. Oncotarget 5:3590–3606. https://doi.org/10.18632/oncotarget.1962

Article  PubMed Central  PubMed  Google Scholar 

Marchal JA, Carrasco E, Ramirez A et al (2013) Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence. Drug Des Devel Ther 7:1301–1313. https://doi.org/10.2147/DDDT.S51354

Article  PubMed Central  PubMed  Google Scholar 

Kim SH, Choi JY (2022) Purinergic signaling in the peripheral vestibular system. Purinergic Signal 18:165–176. https://doi.org/10.1007/s11302-022-09855-5

Article  CAS  PubMed Central  PubMed  Google Scholar 

Zimmermann H, Zebisch M, Sträter N (2012) Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal 8:437–502. https://doi.org/10.1007/s11302-012-9309-4

Article  CAS  PubMed Central  PubMed  Google Scholar 

Colgan SP, Eltzschig HK, Eckle T, Thompson LF (2006) Physiological roles for ecto-5’-nucleotidase (CD73). Purinergic Signal 2:351–360. https://doi.org/10.1007/s11302-005-5302-5

Article  CAS  PubMed Central  PubMed  Google Scholar 

Reyna-Jeldes M, Díaz-Muñoz M, Madariaga JA et al (2021) Autocrine and paracrine purinergic signaling in the most lethal types of cancer. Purinergic Signal 17:345–370. https://doi.org/10.1007/s11302-021-09785-8

Article  CAS  PubMed Central  PubMed  Google Scholar 

Campos-Contreras ADR, Díaz-Muñoz M, Vázquez-Cuevas FG (2020) Purinergic Signaling in the hallmarks of Cancer. Cells 9:1–24. https://doi.org/10.3390/cells9071612

Article  CAS  Google Scholar 

Burnstock G, Di Virgilio F (2013) Purinergic signalling and cancer. Purinergic Signal 9:491–540. https://doi.org/10.1007/s11302-013-9372-5

Article  CAS  PubMed Central  PubMed  Google Scholar 

Stella J, Bavaresco L, Braganhol E et al (2010) Differential ectonucleotidase expression in human Bladder cancer cell lines. Urologic Oncology: Seminars and Original Investigations 28:260–267. https://doi.org/10.1016/j.urolonc.2009.01.035

Article  CAS  PubMed  Google Scholar 

Rockenbach L, Braganhol E, Dietrich F et al (2014) NTPDase3 and ecto-5’-nucleotidase/CD73 are differentially expressed during mouse Bladder cancer progression. Purinergic Signal 10:421–430. https://doi.org/10.1007/s11302-014-9405-8

Article  CAS  PubMed Central  PubMed  Google Scholar 

Nunez M, Diaz-Gavilan M, Conejo-Garcia A et al (2008) Design, synthesis and anticancer activity against the MCF-7 cell line of Benzo-fused 1,4-Dihetero seven- and six-Membered Tethered pyrimidines and purines. Curr Med Chem 15:2614–2631. https://doi.org/10.2174/092986708785909021

Article  CAS  PubMed  Google Scholar 

Figueiró F, Bernardi A, Frozza RL et al (2013) Resveratrol-loaded lipid-core nanocapsules treatment reduces in vitro and in vivo glioma growth. J Biomed Nanotechnol 9:516–526. https://doi.org/10.1166/jbn.2013.1547

Article  CAS  PubMed  Google Scholar 

Chan K-M, Delfert D, Junger KD (1986) A direct colorimetric assay for Ca2+-stimulated ATPase activity. Anal Biochem 157:375–380. https://doi.org/10.1016/0003-2697(86)90640-8

Article  CAS  PubMed  Google Scholar 

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. https://doi.org/10.1016/0003-2697(76)90527-3

Article  CAS  PubMed  Google Scholar 

Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3:1101–1108. https://doi.org/10.1038/nprot.2008.73

Article  CAS  PubMed  Google Scholar 

Xu J, Gewirtz DA (2022) Is autophagy always a barrier to Cisplatin. Therapy? Biomolecules 12:1–22. https://doi.org/10.3390/biom12030463

Article  CAS  Google Scholar 

Sun C, Mezzadra R, Schumacher TN (2018) Regulation and function of the PD-L1 checkpoint. Immunity 48:434–452. https://doi.org/10.1016/j.immuni.2018.03.014

Article  CAS  PubMed Central  PubMed  Google Scholar 

Narayan VM (2021) Radiotherapy with or without chemotherapy in muscle-invasive Bladder Cancer. 50 studies every urologist should know. 147–152. https://doi.org/10.1093/med/9780190655341.003.0026

Torgovnick A, Schumacher B (2015) DNA repair mechanisms in cancer development and therapy. Front Genet 6:1–15. https://doi.org/10.3389/fgene.2015.00157

Article  CAS  Google Scholar 

Choi W, Porten S, Kim S et al (2014) Identification of distinct basal and luminal subtypes of muscle-invasive Bladder Cancer with different sensitivities to Frontline Chemotherapy. Cancer Cell 25:152–165. https://doi.org/10.1016/j.ccr.2014.01.009

Article  CAS  PubMed Central  PubMed  Google Scholar 

Jiang DM, Gupta S, Kitchlu A et al (2021) Defining cisplatin eligibility in patients with muscle-invasive Bladder cancer. Nat Rev Urol 18:104–114. https://doi.org/10.1038/s41585-020-00404-6

Article  PubMed  Google Scholar 

Muller PY, Milton MN (2012) The determination and interpretation of the therapeutic index in drug development. Nat Rev Drug Discov 11:751–761. https://doi.org/10.1038/nrd3801

Article  CAS  PubMed  Google Scholar 

Awang N, Aziz ZA, Kamaludin NF, Chan KM (2014) Cytotoxicity and mode of cell death induced by triphenyltin (IV) compounds in vitro. Online J Biol Sci 14:84–93. https://doi.org/10.3844/ojbsci.2014.84.93

Article  CAS  Google Scholar 

Badisa RB, Darling-Reed SF, Joseph P et al (2009) Selective cytotoxic activities of two novel synthetic Drugs on human breast carcinoma MCF-7 cells. Anticancer Res 29:2993–2996

CAS  PubMed Central  PubMed  Google Scholar 

Quispe MA, Zavala CD, Rojas CJ et al (2006) Efecto citotóxico selectivo in vitro de muricin H (acetogenina de Annona muricata) en cultivos celulares de cáncer de pulmón. Rev Peru Med Exp Salud Publica 23:265–269

Google Scholar 

“Pedro Kourí.” Instituto de Medicina Tropical, del Barrio Alonso S, Gutiérrez Gaitén G (1966) Y, Morier Díaz L Revista cubana de medicina tropical. Editorial Ciencias Médicas

Powles T, Perry J, Shamash J et al (2007) A comparison of the platinum analogues in Bladder cancer cell lines. Urol Int 79:67–72. https://doi.org/10.1159/000102917

Article  CAS  PubMed  Google Scholar 

Rahman NA, Yazan LS, Wibowo A et al (2016) Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative Breast cancer cells, MDA-MB-231. BMC Complement Altern Med 16:1–9. https://doi.org/10.1186/s12906-016-1328-1

Article  CAS  Google Scholar 

Li B, Zhou P, Xu K et al (2020) Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma. Int J Biol Sci 16:74–84. https://doi.org/10.7150/ijbs.33787