Davidson, C. J., Tirouvanziam, R., Herzenberg, L. A., & Lipsick, J. S. (2005). Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Genetics, 169, 215–229. https://doi.org/10.1534/genetics.104.034132

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciciro, Y., & Sala, A. (2021). MYB oncoproteins: emerging players and potential therapeutic targets in human cancer. Oncogenesis, 10, 19. https://doi.org/10.1038/s41389-021-00309-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klempnauer, K. H., Gonda, T. J., & Bishop, J. M. (1982). Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: The architecture of a transduced oncogene. Cell, 31, 453–463. https://doi.org/10.1016/0092-8674(82)90138-6

Article  CAS  PubMed  Google Scholar 

Boyle, W. J., Lipsick, J. S., Reddy, E. P., & Baluda, M. A. (1983). Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue. Proceedings of the National Academy of Science U S A, 80, 2834–2838. https://doi.org/10.1073/pnas.80.10.2834

Article  CAS  Google Scholar 

Oh, I. H., & Reddy, E. P. (1999). The myb gene family in cell growth, differentiation and apoptosis. Oncogene, 18, 3017–33. https://doi.org/10.1038/sj.onc.1202839

Article  CAS  PubMed  Google Scholar 

Nomura, N., Takahashi, M., Matsui, M., Ishii, S., Date, T., Sasamoto, S., et al. (1988). Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. Nucleic Acids Research, 16, 11075–11089. https://doi.org/10.1093/nar/16.23.11075

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramsay, R. G., & Gonda, T. J. (2008). MYB function in normal and cancer cells. Nature Reviews Cancer, 8, 523–534. https://doi.org/10.1038/nrc2439

Article  CAS  PubMed  Google Scholar 

Trauth, K., Mutschler, B., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., & Klempnauer, K. H. (1994). Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B lymphocytes. The EMBO Journal, 13, 5994–6005. https://doi.org/10.1002/j.1460-2075.1994.tb06945.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar, A., Baker, S. J., Lee, C. M., & Reddy, E. P. (2003). Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb. Molecular and Cellular Biology, 23, 6631–45. https://doi.org/10.1128/MCB.23.18.6631-6645.2003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brayer, K. J., Frerich, C. A., Kang, H., & Ness, S. A. (2016). Recurrent fusions in MYB and MYBL1 define a common, transcription factor-driven oncogenic pathway in salivary gland adenoid cystic carcinoma. Cancer Discovery, 6, 176–187. https://doi.org/10.1158/2159-8290.CD-15-0859

Article  CAS  PubMed  Google Scholar 

Chen, X., Feng, J., Zhang, Y., Liu, J., Zhang, L., Zeng, P., et al. (2023). MYBL2 alternative splicing-related genetic variants reduce the risk of triple-negative breast cancer in the Chinese population. Frontiers in Genetics, 14, 1150976. https://doi.org/10.3389/fgene.2023.1150976

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Rourke, J. P., & Ness, S. A. (2008). Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. Molecular and Cellular Biology, 28, 2091–2101. https://doi.org/10.1128/MCB.01870-07

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogata, K., Kanei-Ishii, C., Sasaki, M., Hatanaka, H., Nagadoi, A., Enari, M., et al. (1996). The cavity in the hydrophobic core of Myb DNA-binding domain is reserved for DNA recognition and trans-activation. Natural Structural Biology, 3, 178–187. https://doi.org/10.1038/nsb0296-178

Article  CAS  Google Scholar 

Ogata, K., Hojo, H., Aimoto, S., Nakai, T., Nakamura, H., Sarai, A., et al. (1992). Solution structure of a DNA-binding unit of Myb: A helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core. Proceedings of the National Academy of Sciences U S A, 89, 6428–6432. https://doi.org/10.1073/pnas.89.14.6428

Article  CAS  Google Scholar 

Facchinetti, V., Loffarelli, L., Schreek, S., Oelgeschlager, M., Luscher, B., Introna, M., et al. (1997). Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. Biochemical Journal, 324(Pt 3), 729–36. https://doi.org/10.1042/bj3240729

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rushton, J. J., & Ness, S. A. (2001). The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factors. Blood Cells, Molecules, and Diseases, 27, 459–63. https://doi.org/10.1006/bcmd.2001.0405

Article  CAS  PubMed  Google Scholar 

Ogata, K., Morikawa, S., Nakamura, H., Sekikawa, A., Inoue, T., Kanai, H., et al. (1994). Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell, 79, 639–648. https://doi.org/10.1016/0092-8674(94)90549-5

Article  CAS  PubMed  Google Scholar 

Bergholtz, S., Andersen, T. O., Andersson, K. B., Borrebaek, J., Luscher, B., & Gabrielsen, O. S. (2001). The highly conserved DNA-binding domains of A-, B- and c-Myb differ with respect to DNA-binding, phosphorylation and redox properties. Nucleic Acids Research, 29, 3546–3556. https://doi.org/10.1093/nar/29.17.3546

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakagoshi, H., Takemoto, Y., & Ishii, S. (1993). Functional domains of the human B-myb gene product. Journal of Biological Chemistry, 268, 14161–14167. https://doi.org/10.1016/S0021-9258(19)85222-5

Article  CAS  PubMed  Google Scholar 

Sleeman, J. P. (1993). Xenopus A-myb is expressed during early spermatogenesis. Oncogene, 8, 1931–1941.

CAS  PubMed  Google Scholar 

Katzen, A. L., Kornberg, T. B., & Bishop, J. M. (1985). Isolation of the proto-oncogene c-myb from D. melanogaster. Cell, 41, 449–456. https://doi.org/10.1016/S0092-8674(85)80018-0

Article  CAS  PubMed  Google Scholar 

Kanei-Ishii, C., MacMillan, E. M., Nomura, T., Sarai, A., Ramsay, R. G., Aimoto, S., et al. (1992). Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure. Proceedings National Academy Sciences U S A, 89, 3088–3092. https://doi.org/10.1073/pnas.89.7.3088

Article  CAS  Google Scholar 

Nomura, T., Sakai, N., Sarai, A., Sudo, T., Kanei-Ishii, C., Ramsay, R. G., et al. (1993). Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper. Journal of Biological Chemistry, 268, 21914–21923. https://doi.org/10.1016/S0021-9258(20)80628-0

Article  CAS  PubMed  Google Scholar 

Takahashi, T., Nakagoshi, H., Sarai, A., Nomura, N., Yamamoto, T., & Ishii, S. (1995). Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. FEBS Letters, 358, 89–96. https://doi.org/10.1016/0014-5793(94)01402-M

Article  CAS  PubMed  Google Scholar 

Ziebold, U., & Klempnauer, K. H. (1997). Linking Myb to the cell cycle: Cyclin-dependent phosphorylation and regulation of A-Myb activity. Oncogene, 15, 1011–1019. https://doi.org/10.1038/sj.onc.1201282

Article  CAS  PubMed  Google Scholar 

Ramsay, R. G., Morrice, N., Van Eeden, P., Kanagasundaram, V., Nomura, T., De Blaquiere, J., et al. (1995). Regulation of c-Myb through protein phosphorylation and leucine zipper interactions. Oncogene, 11, 2113–2120.

CAS  PubMed  Google Scholar 

Wijeratne, T. U., Guiley, K. Z., Lee, H. W., Muller, G. A., & Rubin, S. M. (2022). Cyclin-dependent kinase-mediated phosphorylation and the negative regulatory domain of transcription factor B-Myb modulate its DNA binding. Journal of Biological Chemistry, 298, 102319. https://doi.org/10.1016/j.jbc.2022.102319

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomita, A., Watanabe, T., Kosugi, H., Ohashi, H., Uchida, T., Kinoshita, T., et al. (1998). Truncated c-Myb expression in the human leukemia cell line TK-6. Leukemia, 12, 1422–1429. https://doi.org/10.1038/sj.leu.2401113

Article  CAS  PubMed  Google Scholar 

Wallrapp, C., Muller-Pillasch, F., Solinas-Toldo, S., Lichter, P., Friess, H., Buchler, M., et al. (1997). Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene. Cancer Research, 57, 3135–3139.

CAS  PubMed  Google Scholar 

Kauraniemi, P., Hedenfalk, I., Persson, K., Duggan, D. J., Tanner, M., Johannsson, O., et al. (2000). MYB oncogene amplification in hereditary BRCA1 breast cancer. Cancer Research, 60, 5323–5328.

CAS  PubMed  Google Scholar 

Tatevossian, R. G., Tang, B., Dalton, J., Forshew, T., Lawson, A. R., Ma, J., et al. (2010). MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathologica, 120, 731–743. https://doi.org/10.1007/s00401-010-0763-1

Article  PubMed  PubMed Central  Google Scholar 

Schumacher, S. E., Shim, B. Y., Corso, G., Ryu, M. H., Kang, Y. K., Roviello, F., et al. (2017). Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients. PLoS ONE, 12, e0176045. https://doi.org/10.1371/journal.pone.0176045

Article  CAS  PubMed