Syal G, Fausther M, Dranoff JA (2012) Advances in cholangiocyte immunobiology. Am J Physiol Gastrointest Liver Physiol 303:G1077-1086

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wells RG, Schwabe RF (2015) Origin and function of myofibroblasts in the liver. Semin Liver Dis 35:97–106

Article  CAS  PubMed  Google Scholar 

Hammerich L, and Tacke F (2023) Hepatic inflammatory responses in liver fibrosis. Nat Rev Gastroenterol Hepatol 20:633–646

Wynn TA, Barron L (2010) Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 30:245–257

Article  CAS  PubMed  PubMed Central  Google Scholar 

McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y (2023) The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatol 78:649–669

Article  Google Scholar 

Ma C, Brunt EM (2012) Histopathologic evaluation of liver biopsy for cirrhosis. Adv Anat Pathol 19:220–230

Article  PubMed  Google Scholar 

Friedman SL (1999) The virtuosity of hepatic stellate cells. Gastroenterol 117:1244–1246

Article  CAS  Google Scholar 

Dranoff JA, Wells RG (2010) Portal fibroblasts: underappreciated mediators of biliary fibrosis. Hepatol 51:1438–1444

Article  Google Scholar 

Dranoff JA, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, Sevigny J (2004) The ecto-nucleotidase NTPDase2 is selectively down-regulated in biliary fibrosis. J Invest Med 52:475–482

Article  CAS  Google Scholar 

Yu J, Lavoie EG, Sheung N, Tremblay JJ, Sevigny J, Dranoff JA (2008) IL-6 downregulates transcription of NTPDase2 via specific promoter elements. Am J Physiol Gastrointest Liver Physiol 294:G748-756

Article  CAS  PubMed  Google Scholar 

Jhandier MN, Kruglov EA, Lavoie EG, Sevigny J, Dranoff JA (2005) Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2. J Biol Chem 280:22986–22992

Article  CAS  PubMed  Google Scholar 

Lavoie EG, Fausther M, Goree JR, Dranoff JA (2017) The cholangiocyte adenosine-IL-6 axis regulates survival during biliary cirrhosis. Gene Expr 17:327–340

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hashmi AZ, Hakim W, Kruglov EA, Watanabe A, Watkins W, Dranoff JA, Mehal WZ (2007) Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 292:G395-401

Article  CAS  PubMed  Google Scholar 

Sohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, Dranoff JA, Torok NJ, Mehal WZ (2009) Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatol 49:185–194

Article  CAS  Google Scholar 

Ahsan MK, Mehal WZ (2014) Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb. Front Pharmacol 5:69

Article  PubMed  PubMed Central  Google Scholar 

Chan ES, Montesinos MC, Fernandez P, Desai A, Delano DL, Yee H, Reiss AB, Pillinger MH, Chen JF, Schwarzschild MA, Friedman SL, Cronstein BN (2006) Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol 148:1144–1155

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Guan W, Yang W, Wang Q, Zhao H, Yang F, Lv X, Li J (2014) Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway. PLoS ONE 9:e92482

Article  PubMed  PubMed Central  Google Scholar 

Hubel E, Saroha A, Park WJ, Pewzner-Jung Y, Lavoie EG, Futerman AH, Bruck R, Fishman S, Dranoff JA, Shibolet O, Zvibel I (2017) Sortilin deficiency reduces ductular reaction, hepatocyte apoptosis, and liver fibrosis in cholestatic-induced liver injury. Am J Pathol 187:122–133

Article  CAS  PubMed  Google Scholar 

European Association for the Study of the Liver (2021) Electronic address: Clinical Practice Guideline P, Chair, representative EGB, and Panel m. EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - update. J Hepatol 75(659–689):2021

Arroyave-Ospina JC, Buist-Homan M, Schmidt M, Moshage H (2023) Protective effects of caffeine against palmitate-induced lipid toxicity in primary rat hepatocytes is associated with modulation of adenosine receptor A1 signaling. Biomed Pharmacother 165:114884

Article  CAS  PubMed  Google Scholar 

Kakiyama G, Minowa K, Rodriguez-Agudo D, Martin R, Takei H, Mitamura K, Ikegawa S, Suzuki M, Nittono H, Fuchs M, Heuman DM, Zhou H, Pandak WM (2022) Coffee modulates insulin-hepatocyte nuclear factor-4alpha-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model. Am J Physiol Gastrointest Liver Physiol 323:G488–G500

Article  CAS  PubMed  Google Scholar 

Muriel P, Lopez-Sanchez P, Ramos-Tovar E (2021) Fructose and the liver. Int J Mol Sci 22:6969

Robson SC, Schuppan D (2010) Adenosine: tipping the balance towards hepatic steatosis and fibrosis. J Hepatol 52:941–943

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Z, Borea PA, Varani K, Wilder T, Yee H, Chiriboga L, Blackburn MR, Azzena G, Resta G, Cronstein BN (2009) Adenosine signaling contributes to ethanol-induced fatty liver in mice. J Clin Investig 119:582–594

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dranoff JA (2018) Coffee consumption and prevention of cirrhosis. In Support of the caffeine hypothesis. Gene Expr 18:1–3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dranoff JA (2023) Coffee as chemoprotectant in fatty liver disease: caffeine-dependent and caffeine-independent effects. Am J Physiol Gastrointest Liver Physiol 324:G419–G421

Article  CAS  PubMed  Google Scholar 

Dranoff JA, Feld JJ, Lavoie EG, Fausther M (2014) How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations. Hepatol 60:464–467

Article  Google Scholar 

Feld JJ, Lavoie EG, Fausther M, Dranoff JA (2015) I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis. F1000Res 4:95

Ruhl CE, Everhart JE (2005) Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology 128:24–32

Article  CAS  PubMed  Google Scholar 

Corrao G, Zambon A, Bagnardi V, D’Amicis A, Klatsky A (2001) Coffee, caffeine, and the risk of liver cirrhosis. Ann Epidemiol 11:458–465

Article  CAS  PubMed  Google Scholar 

Niezen S, Mehta M, Jiang ZG, Tapper EB (2022) Coffee consumption is associated with lower liver stiffness: a nationally representative study. Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc 20(2032–2040)

Hayat U, Siddiqui AA, Okut H, Afroz S, Tasleem S, Haris A (2021) The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of 11 epidemiological studies. Ann Hepatol 20:100254

Article  CAS  PubMed  Google Scholar 

Whitfield JB, Masson S, Liangpunsakul S, Mueller S, Aithal GP, Eyer F, Gleeson D, Thompson A, Stickel F, Soyka M, Muellhaupt B, Daly AK, Cordell HJ, Foroud T, Lumeng L, Pirmohamed M, Nalpas B, Jacquet JM, Moirand R, Nahon P, Naveau S, Perney P, Haber PS, Seitz HK, Day CP, Mathurin P, Morgan TR, Seth D, Genom ALCC (2021) Obesity, diabetes, coffee, tea, and cannabis use alter risk for alcohol-related cirrhosis in 2 large cohorts of high-risk drinkers. Am J Gastroenterol 116:106–115

Article  PubMed  Google Scholar 

Ebadi M, Ip S, Bhanji RA, Montano-Loza AJ (2021) Effect of coffee consumption on non-alcoholic fatty liver disease incidence, prevalence and risk of significant liver fibrosis: systematic review with meta-analysis of observational studies. Nutrients 13:3042

Sewter R, Heaney S, and Patterson A (2021) Coffee consumption and the progression of NAFLD: a systematic review. Nutrients 13:2381

Lammert C, Chalasani SN, Green K, Atkinson E, McCauley B, Lazaridis KN (2022) Patients with autoimmune hepatitis report lower lifetime coffee consumption. Dig Dis Sci 67:2594–2599

Article  CAS  PubMed  Google Scholar 

Lammert C, Juran BD, Schlicht E, Xie X, Atkinson EJ, de Andrade M, Lazaridis KN (2014) Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis. Clin Gastroenterol Hepatol : Off Clin pract J Am Gastroenterol Assoc 12:1562–1568

Article  Google Scholar 

Gershbein LL, Baburao K (1980) Effect of feeding coffee and its lipids on regenerating and intact liver. Res Commun Chem Pathol Pharmacol 28:457–472

CAS  PubMed  Google Scholar 

Yoon CS, Kim MK, Kim YS, Lee SK (2018) In vivo protein expression changes in mouse livers treated with dialyzed coffee extract as determined by IP-HPLC. Maxillofac Plast Reconstr Surg 40:44

Article  PubMed  PubMed Central  Google Scholar 

Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M (2017) Emerging concepts in biliary repair and fibrosis. Am J Physiol Gastrointest Liver Physiol 313:G102–G116

Article  PubMed  PubMed Central  Google Scholar 

Lange NF, Radu P, Dufour JF (2021) Prevention of NAFLD-associated HCC: role of lifestyle and chemoprevention. J Hepatol 75:1217–1227

Article  CAS  PubMed  Google Scholar 

Njei B, McCarty TR, Sharma P, Lange A, Najafian N, Ngu JN, Ngomba VE, Echouffo-Tcheugui JB (2018) Bariatric surgery and hepatocellular carcinoma: a propensity score-matched analysis. Obes Surg 28:3880–3889

Article  PubMed  PubMed Central