Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol. 2012;8(11):639–49.
Article CAS PubMed PubMed Central Google Scholar
Bhavadharini B, Mahalakshmi MM, Anjana RM, Maheswari K, Uma R, Deepa M, et al. Prevalence of gestational diabetes mellitus in urban and rural Tamil Nadu using IADPSG and WHO 1999 criteria (WINGS 6). Clin Diabetes Endocrinol. 2016;2:8.
Article PubMed PubMed Central Google Scholar
Choudhury AA, Devi Rajeswari V. Gestational diabetes mellitus - A metabolic and reproductive disorder. Biomed Pharmacother Biomedecine Pharmacother. 2021;143:112183.
Seshiah V, Balaji V, Balaji MS, Paneerselvam A, Arthi T, Thamizharasi M, et al. Gestational diabetes mellitus manifests in all trimesters of pregnancy. Diabetes Res Clin Pract. 2007;77(3):482–4.
Saravanan P, Diabetes in Pregnancy Working Group, Maternal Medicine Clinical Study Group. Royal college of obstetricians and Gynaecologists, UK. Gestational diabetes: opportunities for improving maternal and child health. Lancet Diabetes Endocrinol. 2020 Sept;8(9):793–800.
Ye W, Luo C, Huang J, Li C, Liu Z, Liu F. Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2022;377:e067946.
Article PubMed PubMed Central Google Scholar
Diaz-Santana MV, O’Brien KM, Park YMM, Sandler DP, Weinberg CR. Persistence of risk for type 2 diabetes after gestational diabetes mellitus. Diabetes Care. 2022;45(4):864–70.
Article PubMed PubMed Central Google Scholar
Kramer CK, Campbell S, Retnakaran R. Gestational diabetes and the risk of cardiovascular disease in women: a systematic review and meta-analysis. Diabetologia. 2019;62(6):905–14.
Yu Y, Soohoo M, Sørensen HT, Li J, Arah OA. Gestational diabetes mellitus and the risks of overall and type-specific cardiovascular diseases: a population- and sibling-matched cohort study. Diabetes Care. 2022;45(1):151–9.
Chen A, Tan B, Du R, Chong YS, Zhang C, Koh AS, et al. Gestational diabetes mellitus and development of intergenerational overall and subtypes of cardiovascular diseases: a systematic review and meta-analysis. Cardiovasc Diabetol. 2024;23(1):320.
Article PubMed PubMed Central Google Scholar
Lorenzo-Almorós A, Hang T, Peiró C, Soriano-Guillén L, Egido J, Tuñón J, et al. Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases. Cardiovasc Diabetol. 2019;18(1):140.
Article PubMed PubMed Central Google Scholar
Moon JH, Choi SH. Advancing early prediction of gestational diabetes mellitus with circular RNA biomarkers. Diabetes Metab J. 2025;49(3):403–4.
Article PubMed PubMed Central Google Scholar
Pramodkumar TA, Hannah W, Anjana RM, Ram U, Tiwaskar M, Gokulakrishnan K, et al. Biomarkers of gestational diabetes mellitus: mechanisms, advances, and clinical utility. J Assoc Physicians India. 2025;73(2):56–67.
Yang J, Cao Y, Qian F, Grewal J, Sacks DB, Chen Z et al. Early prediction of gestational diabetes mellitus based on systematically selected multi-panel biomarkers and clinical accessibility-a longitudinal study of a multi-racial pregnant cohort. BMC Med. 2025;23(1):430.
Razo-Azamar M, Nambo-Venegas R, Meraz-Cruz N, Guevara-Cruz M, Ibarra-González I, Vela-Amieva M et al. An early prediction model for gestational diabetes mellitus based on metabolomic biomarkers. Diabetol Metab Syndr. 2023;15(1):116.
Jung Y, Lee SM, Lee J, Kim Y, Lee W, Koo JN, et al. Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis. Cardiovasc Diabetol. 2025;24(1):125.
Article CAS PubMed PubMed Central Google Scholar
Zhao H, Zheng Y, Zhu L, Xiang L, Xu S, Cai Z. Trimester-specific urinary metabolome alterations associated with gestational diabetes mellitus: a study in different pregnancy stages. Chin Chem Lett. 2022;33(6):3139–43.
Scholtens DM, Kuang A, Lowe LP, Hamilton J, Lawrence JM, Lebenthal Y, et al. Hyperglycemia and adverse pregnancy outcome follow-up study (HAPO FUS): maternal glycemia and childhood glucose metabolism. Diabetes Care. 2019;42(3):381–92.
Article CAS PubMed PubMed Central Google Scholar
Mokkala K, Vahlberg T, Pellonperä O, Houttu N, Koivuniemi E, Laitinen K. Distinct metabolic profile in early pregnancy of overweight and obese women developing gestational diabetes. J Nutr. 2020;150(1):31–7.
Kong M, Lu Z, Zhong C, Gao Q, Zhou X, Chen R, et al. A higher level of total bile acid in early mid-pregnancy is associated with an increased risk of gestational diabetes mellitus: a prospective cohort study in Wuhan, China. J Endocrinol Invest. 2020;43(8):1097–103.
Article CAS PubMed Google Scholar
Li J, Huo X, Cao YF, Li SN, Du Z, Shao P, et al. Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: a nested case-control study. EBioMedicine. 2018;35:317–24.
Lu C, Li C, Lei X. Bile acids and gestational diabetes mellitus: exploring the link and implications—a review. Front Endocrinol. 2025;16:1574228.
Gao B, Shen Q, Wu Y, Cao M, Zhang Q, Chen L. Branched-chain and aromatic amino acid levels response to an oral glucose load associated with gestational diabetes mellitus. Sci Rep. 2022;12(1):12257.
Susarla SM, Fiehn O, Thiele I, Ngo AL, Barupal DK, Chehab RF, et al. Microbiome-derived metabolites in early to mid-pregnancy and risk of gestational diabetes: a metabolome-wide association study. BMC Med. 2024;22(1):449.
Article CAS PubMed PubMed Central Google Scholar
Thirumoorthy C, Rekha RP, Deepa M, Ram U, Shalu D, Venkatesan U, et al. Association of early pregnancy telomere length and mitochondrial copy number with gestational diabetes mellitus and depressive symptoms. Psychoneuroendocrinology. 2025;176:107431.
Yu J, Ren J, Ren Y, Wu Y, Zeng Y, Zhang Q, et al. Using metabolomics and proteomics to identify the potential urine biomarkers for prediction and diagnosis of gestational diabetes. eBioMedicine. 2024;101:105008.
Article CAS PubMed PubMed Central Google Scholar
Borges Manna L, Syngelaki A, Würtz P, Koivu A, Sairanen M, Pölönen T et al. First-trimester nuclear magnetic resonance-based metabolomic profiling increases the prediction of gestational diabetes mellitus. Am J Obstet Gynecol. 2025;233(1):71.e1-71.e14.
Lappas M, Mundra PA, Wong G, Huynh K, Jinks D, Georgiou HM, et al. The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics. Diabetologia. 2015;58(7):1436–42.
Liu J, Li J, Li S, Leng J, Li W, Yang W, et al. Circulating lysophosphatidylcholines in early pregnancy and risk of gestational diabetes in Chinese women. J Clin Endocrinol Metab. 2020;105(4):dgaa058.
Rahman ML, Feng YCA, Fiehn O, Albert PS, Tsai MY, Zhu Y, et al. Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial/ethnic cohort. BMJ Open Diabetes Res Care. 2021;9(1):e001551.
Article PubMed PubMed Central Google Scholar
Wang Y, Huang Y, Wu P, Ye Y, Sun F, Yang X, et al. Plasma lipidomics in early pregnancy and risk of gestational diabetes mellitus: a prospective nested case-control study in Chinese women. Am J Clin Nutr. 2021;114(5):1763–73.
Article CAS PubMed Google Scholar
Dudzik D, Atanasova V, Barbas C, Bartha JL. First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls. Front Mol Biosci. 2024;11:1452312.
Article CAS PubMed Google Scholar
Saravanan P, Deepa M, Ahmed Z, Ram U, Surapaneni T, Kallur SD, et al. Early pregnancy HbA1c as the first screening test for gestational diabetes: results from three prospective cohorts. Lancet Diabetes Endocrinol. 2024;12(8):535–44.
Article CAS PubMed Google Scholar
International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676–82.
Article PubMed Central Google Scholar
Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem. 2009;81(16):6656–67.
Article CAS PubMed Google Scholar
Cajka T, Smilowitz JT, Fiehn O. Validating quantitative untargeted lipidomics across nine liquid chromatography-high-resolution mass spectrometry platforms. Anal Chem. 2017;89(22):12360–8.
Article CAS PubMed Google Scholar
Zimmer DM, Golichowski AM, Karn CA, Brechtel G, Baron AD, Denne SC. Glucose and amino acid turnover in untreated gestational diabetes. Diabetes Care. 1996;19(6):591–6.
Shryack GE, Krause AA, Hernandez Ruano S, Schulz LC, Pennington KA, Rector RS. A murine model of gestational diabetes reveals MASLD risk and alterations in markers of hepatic mitochondrial metabolism. Front Endocrinol [Internet]. 2025 June 25 [cited 2025 Aug 3];16. https://www.frontiersin.org/journals/endocrinology/articles/https://doi.org/10.3389/fendo.2025.1498764/full
Guasch-Ferré M, Hruby A, Toledo E, Clish CB, Martínez-González MA, Salas-Salvadó J, et al. Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis. Diabetes Care. 2016;39(5):833–46.
Article PubMed PubMed Central Google Scholar
Unnikrishnan R, Anjana RM, Mohan V. Diabetes mellitus and its complications in India. Nat Rev Endocrinol. 2016;12(6):357–70.
Duft RG, Castro A, Bonfante ILP, Lopes WA, da Silva LR, Chacon-Mikahil MPT, et al. Serum metabolites associated with increased insulin resistance and low cardiorespiratory fitness in overweight adolescents. Nutr Metab Cardiovasc Dis NMCD. 2022;32(1):269–78.
Article CAS PubMed Google Scholar
Zhang Z, Zhou Z, Li H. The role of lipid dysregulation in gesta
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