Antinociceptive, anti-inflammatory, and antiophidic potential of leaves extract and fraction: an in vitro and in vivo evaluation

Acquadro S, Civra A, Cagliero C, Marengo A, Rittà M, Francese R et al (2020) Punica granatum leaf ethanolic extract and ellagic acid as inhibitors of Zika virus infection. Planta Med 86(18):1363–1374. https://doi.org/10.1055/a-1232-5705

Article  PubMed  CAS  Google Scholar 

Adrião AAX, dos Santos AO, de Lima EJSP, Maciel JB, Paz WHP, da Silva FMA et al (2022) Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations (Review). Front Immunol. https://doi.org/10.3389/fimmu.2022.842576

Article  PubMed  PubMed Central  Google Scholar 

Ali A, Nasir A, Shah SWA, Khalil AAK, Ahn M-J, Shah SMM et al (2021) Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice. BMC Complement Med Ther 21(1):184. https://doi.org/10.1186/s12906-021-03357-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Araújo SCM, Câmara JT, Guedes TB (2023) Snakebites in Northeastern Brazil: accessing clinical-epidemiological profile as a strategy to deal with neglected tropical diseases. Rev Soc Bras Med Trop. https://doi.org/10.1590/0037-8682-0224-2023

Article  PubMed  PubMed Central  Google Scholar 

Balwani S, Nandi D, Jaisankar P, Ghosh B (2011) 2-Methyl-pyran-4-one-3-O-β-d-glucopyranoside isolated from leaves of Punica granatum inhibits the TNFα-induced cell adhesion molecules expression by blocking nuclear transcription factor-κB (NF-κB). Biochimie 93(5):921–930. https://doi.org/10.1016/j.biochi.2011.01.010

Article  PubMed  CAS  Google Scholar 

Bekir J, Mars M, Souchard JP, Bouajila J (2013) Assessment of antioxidant, anti-inflammatory, anti-cholinesterase and cytotoxic activities of pomegranate (Punica granatum) leaves. Food Chem Toxicol 55:470–475. https://doi.org/10.1016/j.fct.2013.01.036

Article  PubMed  CAS  Google Scholar 

Bezerra ICF, Ramos RTdM, Ferreira MRA, Soares LAL (2018) Chromatographic profiles of extractives from leaves of Eugenia uniflora. Rev Bras Farmacogn. https://doi.org/10.1016/j.bjp.2017.11.002

Article  Google Scholar 

Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78(3):206–209. https://doi.org/10.1111/1523-1747.ep12506462

Article  PubMed  CAS  Google Scholar 

Cotrim CA, de Oliveira SC, Diz Filho EB, Fonseca FV, Baldissera L Jr, Antunes E et al (2011) Quercetin as an inhibitor of snake venom secretory phospholipase A2. Chem Biol Interact 189(1–2):9–16. https://doi.org/10.1016/j.cbi.2010.10.016

Article  PubMed  CAS  Google Scholar 

Daniele-Silva A, Lucas Tenório CJ, da Costa R, Rodrigues J, Torres-Rêgo M, Cavalcanti FF, de Sousa Ferreira S et al (2024a) Anti-inflammatory and antiophidic effects of extract of Hymenaea eriogyne Benth and structure-activity relationship prediction of the major markers in silico. J Ethnopharmacol 335:118619. https://doi.org/10.1016/j.jep.2024.118619

Article  PubMed  CAS  Google Scholar 

Daniele-Silva A, Parente AMS, de Sousa Ferreira S, Pontes da Silva D, Torres-Rêgo M, Cavalcanti FF et al (2024) In vitro and in vivo anti-inflammatory and antiophidic effects of the extract and fraction of Eugenia uniflora. J Ethnopharmacol 319:117223. https://doi.org/10.1016/j.jep.2023.117223

Article  PubMed  CAS  Google Scholar 

de Lima LB, da Silva WAV, dos Santos ECF, Machado JCB, Procópio TF, de Moura MC et al (2021) Evaluation of antioxidant, antibacterial and enhancement of antibiotic action by Punica granatum leaves crude extract and enriched fraction against multidrug-resistant bacteria. Chem Biodivers 18(12):e2100538. https://doi.org/10.1002/cbdv.202100538

Article  PubMed  CAS  Google Scholar 

de Moura VM, Freitas de Sousa LA, Cristina Dos-Santos M, Almeida Raposo JD, Evangelista Lima A, de Oliveira RB et al (2015) Plants used to treat snakebites in Santarém, western Pará, Brazil: an assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom. J Ethnopharmacol 161:224–232. https://doi.org/10.1016/j.jep.2014.12.020

Article  PubMed  Google Scholar 

Félix-Silva J, Gomes JAS, Fernandes JM, Moura AKC, Menezes YAS, Santos ECG et al (2018) Comparison of two Jatropha species (Euphorbiaceae) used popularly to treat snakebites in Northeastern Brazil: chemical profile, inhibitory activity against Bothrops erythromelas venom and antibacterial activity. J Ethnopharmacol 213:12–20. https://doi.org/10.1016/j.jep.2017.11.002

Article  PubMed  Google Scholar 

Ferreira SS, Silva DP, Rêgo MT, Silva-Júnior AA, Pedrosa MFF (2022) The potential of phenolic acids in therapy against snakebites: a review. Toxicon 208:1–12. https://doi.org/10.1016/j.toxicon.2021.12.019

Article  PubMed  CAS  Google Scholar 

Galvão MAM, Arruda AOd, Bezerra ICF, Ferreira MRA, Soares LAL (2018) Evaluation of the Folin-Ciocalteu Method and Quantification of Total Tannins in Stem Barks and Pods from Libidibia ferrea (Mart. ex Tul) L. P. Queiroz. Brazil Archiv Biol Technol 61. https://doi.org/10.1590/1678-4324-2018170586

Ge S, Duo L, Wang J, Gegen Z, Yang J, Li Z et al (2021) A unique understanding of traditional medicine of pomegranate, Punica granatum L. and its current research status. J Ethnopharmacol 271:113877. https://doi.org/10.1016/j.jep.2021.113877

Article  PubMed  CAS  Google Scholar 

Gómez-Betancur I, Gogineni V, Salazar-Ospina A, León F (2019) Perspective on the therapeutics of anti-snake venom. Molecules. https://doi.org/10.3390/molecules24183276

Article  PubMed  PubMed Central  Google Scholar 

Guerrero-Solano JA, Jaramillo-Morales OA, Velázquez-González C, O-Arciniega M, Castañeda-Ovando A, Betanzos-Cabrera G et al (2020) Pomegranate as a potential alternative of pain management: a review. Plants 9(4):419. https://doi.org/10.3390/plants9040419

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gupta M, Singh N, Gulati M, Gupta R, Sudhakar K, Kapoor B (2021) Herbal bioactives in treatment of inflammation: an overview. S Afr J Bot 143:205–225. https://doi.org/10.1016/j.sajb.2021.07.027

Article  CAS  Google Scholar 

Gutiérrez JM, Escalante T, Rucavado A, Herrera C, Fox JW (2016) A comprehensive view of the structural and functional alterations of extracellular matrix by Snake venom metalloproteinases (SVMPs): novel perspectives on the pathophysiology of envenoming. Toxins. https://doi.org/10.3390/toxins8100304

Article  PubMed  PubMed Central  Google Scholar 

Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30(1):103–114. https://doi.org/10.1016/0304-3959(87)90088-1

Article  PubMed  CAS  Google Scholar 

Jain V, Pareek A, Bhardwaj YR, Sinha SK, Gupta MM, Singh N (2022) Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition. Nutr Neurosci 25(10):2149–2166. https://doi.org/10.1080/1028415X.2021.1954293

Article  PubMed  CAS  Google Scholar 

Jiang Y, Zhao Y, Ma X, Zhao X, Zheng M, Wen J et al (2025) Luteolin attenuates RA-associated chronic pain by targeting the LDHA/H3K9la/NFATC2 axis to suppress Th17 cell differentiation and central infiltration. J Pharma Anal. https://doi.org/10.1016/j.jpha.2025.101373

Article  Google Scholar 

Kaur B, Singh P (2022) Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2. Bioorg Chem 121:105663. https://doi.org/10.1016/j.bioorg.2022.105663

Article  PubMed  CAS  Google Scholar 

Khatun A, Imam MZ, Rana MS (2015) Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice. BMC Complement Altern Med 15:63. https://doi.org/10.1186/s12906-015-0558-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kuppusamy UR, Khoo HE, Das NP (1990) Structure-activity studies of flavonoids as inhibitors of hyaluronidase. Biochem Pharmacol 40(2):397–401. https://doi.org/10.1016/0006-2952(90)90709-t

Article  PubMed  CAS  Google Scholar 

Lapa AJ, Souccar C, Lima-Landman MTR, Castro MSA, Lima TCM (2008) Métodos de avaliação da atividade farmacológica de plantas medicinais. S. B. d. P. Medicinais. p. 144

Luo P, Ji Y, Liu X, Zhang W, Cheng R, Zhang S et al (2023) Affected inflammation-related signaling pathways in snake envenomation: a recent insight. Toxicon 234:107288. https://doi.org/10.1016/j.toxicon.2023.107288

Article  PubMed  CAS 

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