Ozone therapy and the role of the glutathione pathway

Bocci V, Aldinucci C, Mosci F, Carraro F, Valacchi G (2007) Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70. Mediators Inflamm 2007:26785. https://doi.org/10.1155/2007/26785

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chirumbolo S, Valdenassi L, Simonetti V, Bertossi D, Ricevuti G, Franzini M, Pandolfi S (2021) Insights on the mechanisms of action of ozone in the medical therapy against COVID-19. Int Immunopharmacol 96:107777. https://doi.org/10.1016/j.intimp.2021.107777

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chirumbolo S, Tirelli U, Franzini M, Pandolfi S, Ricevuti G, Vaiano F, Valdenassi L (2023a) Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties. Hum Exp Toxicol. https://doi.org/10.1177/09603271231218926

Article  PubMed  Google Scholar 

Chirumbolo S, Valdenassi L, Tirelli U, Ricevuti G, Pandolfi S, Vaiano F, Galoforo A, Loprete F, Simonetti V, Chierchia M, Bellardi D, Richelmi T, Franzini M (2023b) The oxygen-ozone adjunct medical treatment according to the protocols from the Italian Scientific Society of Oxygen-Ozone Therapy: how ozone applications in the blood can influence clinical therapy success via the modulation of cell biology and immunity. Biology 12(12):1512. https://doi.org/10.3390/biology12121512

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chirumbolo S, Valdenassi L, Pandolfi S, Tirelli U, Franzini M (2024) Medical use of adjunct oxygen-ozone therapy and its impact on the scientific literature to date. Lancet Reg Health Am 35:100807. https://doi.org/10.1016/j.lana.2024.100807

Article  PubMed  PubMed Central  Google Scholar 

Chirumbolo S, Franzini M, Valdenassi L (2025a) About the ozone ability in using adaptive chaos to restore a healthy state in the oxygen-ozone adjunct therapy. Int Immunopharmacol 147:113967. https://doi.org/10.1016/j.intimp.2024.113967

Article  CAS  PubMed  Google Scholar 

Chirumbolo S, Franzini M, Ricevuti G, Valdenassi L (2025b) Intravenous glutathione should not be mismatched with ozone as an antioxidant therapy. Biomed Pharmacother 188:118197. https://doi.org/10.1016/j.biopha.2025.118197

Article  PubMed  Google Scholar 

Chirumbolo S, Ricevuti G, Franzini M, Vaiano F, Galoforo AC, Richelmi T, Tirelli U, Valdenassi L (2025c) Oxygen-ozone adjunct therapy in aging and senescence-related disorders. State of Art Adv Pharmacol 104:417–446. https://doi.org/10.1016/bs.apha.2025.03.001

Article  PubMed  Google Scholar 

Cisterna B, Costanzo M, Nodari A, Galiè M, Zanzoni S, Bernardi P, Covi V, Tabaracci G, Malatesta M (2020) Ozone activates the Nrf2 pathway and improves preservation of explanted adipose tissue in vitro. Antioxidants (Basel) 9(10):989. https://doi.org/10.3390/antiox9100989

Article  CAS  PubMed  Google Scholar 

Elvis AM, Ekta JS (2011) Ozone therapy: a clinical review. J Nat Sci Biol Med 2(1):66–70. https://doi.org/10.4103/0976-9668.82319

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franzini M, Tirelli U, Valdenassi L, Vaiano F, Galoforo AC, Ricevuti G, Chirumbolo S (2024) Oxygen-ozone therapy in the medical sciences. State of art. Int Immunopharmacol 137:112489. https://doi.org/10.1016/j.intimp.2024.112489

Article  CAS  PubMed  Google Scholar 

Giustarini D, Colombo G, Garavaglia ML, Astori E, Portinaro NM, Reggiani F, Badalamenti S, Aloisi AM, Santucci A, Rossi R, Milzani A, Dalle-Donne I (2017) Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells. Free Radic Biol Med 112:360–375. https://doi.org/10.1016/j.freeradbiomed.2017.08.008

Article  CAS  PubMed  Google Scholar 

Scassellati C, Galoforo AC, Bonvicini C, Esposito C, Ricevuti G (2020) Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Ageing Res Rev 63:101138. https://doi.org/10.1016/j.arr.2020.101138

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA (2017) Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res 7(3):212–219. https://doi.org/10.4103/2045-9912.215752

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tirelli U, Franzini M, Valdenassi L, Pisconti S, Taibi R, Torrisi C, Pandolfi S, Chirumbolo S (2021) Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients. Eur Rev Med Pharmacol Sci 25(18):5871–5875. https://doi.org/10.26355/eurrev_202109_26809

Article  CAS  PubMed  Google Scholar 

Viebahn-Haensler R, León Fernández OS, Ozone in Medicine (2021) The low-dose ozone concept and its basic biochemical mechanisms of action in chronic inflammatory diseases. Int J Mol Sci 22(15):7890. https://doi.org/10.3390/ijms22157890

Article  CAS  PubMed  PubMed Central  Google Scholar 

Viebahn-Haensler R, León Fernández OS (2023a) Ozone in medicine. The low-dose ozone concept. The redox-bioregulatory effect as prominent biochemical mechanism and the role of glutathione. Ozone Sci Eng 46(3):267–279

Article  Google Scholar 

Viebahn-Haensler R, León Fernández OS (2023b) Ozone as redox bioregulator in preventive medicine: the molecular and pharmacological basis of the low-dose ozone concept-a review. Int J Mol Sci 24(21):15747. https://doi.org/10.3390/ijms242115747

Article  CAS  PubMed  PubMed Central  Google Scholar 

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