Aborode AT, Adesola RO, Scott GY et al (2025) Role of blood-brain barrier in bacterial translocation. Neuroscience 580:99–114. https://doi.org/10.1016/J.NEUROSCIENCE.2025.06.037

Article  CAS  PubMed  Google Scholar 

Abulaban AA, Al-kuraishy HM, Al-Gareeb AI et al (2025) The janus face of astrocytes in multiple sclerosis: balancing protection and pathology. Brain Res Bull 226:111356. https://doi.org/10.1016/j.brainresbull.2025.111356

Article  CAS  PubMed  Google Scholar 

Adamu A, Li S, Gao F, Xue G (2024) The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets. Front Aging Neurosci. https://doi.org/10.3389/fnagi.2024.1347987

Article  PubMed  PubMed Central  Google Scholar 

Afshari A, Khorramdelazad H, Abbasifard M (2025) Toward immune tolerance in rheumatoid arthritis: emerging immunotherapies and targets for long-term remission. Int Immunopharmacol 162:115162. https://doi.org/10.1016/J.INTIMP.2025.115162

Article  CAS  PubMed  Google Scholar 

Ahmed H, Mahmud AR, Siddiquee MFR et al (2022) Role of T cells in cancer immunotherapy: opportunities and challenges. Cancer Pathog Ther 1:116. https://doi.org/10.1016/J.CPT.2022.12.002

Article  PubMed  PubMed Central  Google Scholar 

Alcaide P (2022) Mechanisms regulating T cell-endothelial cell interactions. Cold Spring Harb Perspect Med 12:a041170. https://doi.org/10.1101/CSHPERSPECT.A041170

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allard D, Allard B, Stagg J (2020) On the mechanism of anti-CD39 immune checkpoint therapy. J Immunother Cancer 8:e000186. https://doi.org/10.1136/JITC-2019-000186

Article  PubMed  PubMed Central  Google Scholar 

Alshahrani SM, Al-kuraishy HM, Al-Gareeb AI et al (2025) LRP1 at the crossroads of Parkinson’s and Alzheimer’s: divergent roles in α-synuclein and amyloid pathology. Eur J Pharmacol. https://doi.org/10.1016/j.ejphar.2025.177830

Article  PubMed  Google Scholar 

Amit I, Levitin N, Gadrich M et al (2023) Negative feedback expansion of tregs caused by endogenous IL-2 limits the activity of IL-2-based therapies. J Cancer Immunol 5(1):29–39. https://doi.org/10.33696/CANCERIMMUNOL.5.074

Article  Google Scholar 

Angelini G, Bani A, Constantin G, Rossi B (2023) The interplay between T helper cells and brain barriers in the pathogenesis of multiple sclerosis. Front Cell Neurosci 17:1101379. https://doi.org/10.3389/FNCEL.2023.1101379

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arve-Butler S, Moorman CD (2024) A comprehensive overview of tolerogenic vaccine adjuvants and their modes of action. Front Immunol 15:1494499. https://doi.org/10.3389/FIMMU.2024.1494499

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashhurst TM, van Vreden C, Niewold P, King NJC (2014) The plasticity of inflammatory monocyte responses to the inflamed central nervous system. Cell Immunol 291:49. https://doi.org/10.1016/J.CELLIMM.2014.07.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashique S, Mohanto S, Ahmed MG et al (2024) Gut-brain axis: a cutting-edge approach to target neurological disorders and potential synbiotic application. Heliyon 10:e34092. https://doi.org/10.1016/J.HELIYON.2024.E34092

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atkinson EA, Barry M, Darmon AJ et al (1998) Cytotoxic T lymphocyte-assisted suicide: Caspase 3 activation is primarily the result of the direct action of granzyme B. J Biol Chem 273:21261–21266. https://doi.org/10.1074/JBC.273.33.21261

Article  CAS  PubMed  Google Scholar 

Ayasoufi K, Wolf DM, Namen SL et al (2023) Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS viral infection. Brain Behav Immun 112:51–76. https://doi.org/10.1016/J.BBI.2023.05.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badawi GA, Shokr MM, Elshazly SM et al (2024) Sigma-1 receptor modulation by clemastine highlights its repurposing as neuroprotective agent against seizures and cognitive deficits in PTZ-kindled rats. Eur J Pharmacol 980:176851. https://doi.org/10.1016/J.EJPHAR.2024.176851

Article  CAS  PubMed  Google Scholar 

Balasa R, Barcutean L, Mosora O, Manu D (2021) Reviewing the significance of blood–brain barrier disruption in multiple sclerosis pathology and treatment. Int J Mol Sci 22:8370. https://doi.org/10.3390/IJMS22168370

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benne N, ter Braake D, Porenta D et al (2024) Autoantigen–dexamethasone conjugate-loaded liposomes halt arthritis development in mice. Adv Healthc Mater 13:2304238. https://doi.org/10.1002/ADHM.202304238

Article  CAS  Google Scholar 

Bettini ML, Vignali DAA (2010) Development of thymically-derived natural regulatory T cells. Ann N Y Acad Sci 1183:1. https://doi.org/10.1111/J.1749-6632.2009.05129.X

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brahmer JR, Lacchetti C, Schneider BJ et al (2018) Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American society of clinical oncology clinical practice guideline. J Clin Oncol 36:1714. https://doi.org/10.1200/JCO.2017.77.6385

Article  CAS  PubMed  Google Scholar 

Brockmann L, Giannou AD, Gagliani N, Huber S (2017) Regulation of TH17 cells and associated cytokines in wound healing, tissue regeneration, and carcinogenesis. Int J Mol Sci 18:1033. https://doi.org/10.3390/IJMS18051033

Article  PubMed  PubMed Central  Google Scholar 

Cai J, Culley MK, Zhao Y, Zhao J (2017) The role of ubiquitination and deubiquitination in the regulation of cell junctions. Protein Cell 99(9):754–769. https://doi.org/10.1007/S13238-017-0486-3

Article  Google Scholar 

Chen X, Subleski JJ, Hamano R et al (2010) Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FoxP3+ regulatory T cells in human peripheral blood. Eur J Immunol 40:1099. https://doi.org/10.1002/EJI.200940022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Song M, Yao C (2022) Calcineurin in development and disease. Genes Dis 9:915–927. https://doi.org/10.1016/J.GENDIS.2021.03.002

Article  CAS  PubMed  Google Scholar 

Chi H, Pepper M, Thomas PG (2024) Principles and therapeutic applications of adaptive immunity. Cell 187:2052–2078. https://doi.org/10.1016/J.CELL.2024.03.037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chikhoune L, Poggi C, Moreau J et al (2025) JAK inhibitors (JAKi): mechanisms of action and perspectives in systemic and autoimmune diseases. Rev Med Interne 46:89–106. https://doi.org/10.1016/J.REVMED.2024.10.452

Article  PubMed  Google Scholar 

Cohan S, Lucassen E, Smoot K et al (2020) Sphingosine-1-phosphate: its pharmacological regulation and the treatment of multiple sclerosis: a review article. Biomedicines 8:227. https://doi.org/10.3390/BIOMEDICINES8070227

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coyle PK, Freedman MS, Cohen BA et al (2024) Sphingosine 1-phosphate receptor modulators in multiple sclerosis treatment: a practical review. Ann Clin Transl Neurol 11:842–855. https://doi.org/10.1002/ACN3.52017

Article  CAS