Altman R, Luciardi HL, Muntaner J, Herrera RN (2004) The antithrombotic profile of aspirin. Aspirin resistance, or simply failure? Thromb J 2:1

Article  PubMed  PubMed Central  Google Scholar 

Bagaev AV, Garaeva AY, Lebedeva ES, Pichugin AV, Ataullakhanov RI, Ataullakhanov FI (2019) Elevated pre-activation basal level of nuclear NF-kappaB in native macrophages accelerates LPS-induced translocation of cytosolic NF-kappaB into the cell nucleus. Sci Rep 9:4563

Article  PubMed  PubMed Central  Google Scholar 

Beck-Joseph J, Lehoux S (2021) Molecular interactions between vascular smooth muscle cells and macrophages in atherosclerosis. Front Cardiovasc Med. https://doi.org/10.3389/fcvm.2021.737934

Article  PubMed  PubMed Central  Google Scholar 

Chan AT, Ogino S, Fuchs CS (2007) Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med 356:2131–2142

Article  CAS  PubMed  Google Scholar 

Cheng QJ, Ohta S, Sheu KM, Spreafico R, Adelaja A, Taylor B, Hoffmann A (2021) NF-kappaB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science 372:1349–1353

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiang N, Serhan CN (2004) Aspirin triggers formation of anti-inflammatory mediators: New mechanism for an old drug. Discov Med 4:470–475

PubMed  Google Scholar 

Chiang N, Serhan CN (2020) Specialized pro-resolving mediator network: an update on production and actions. Essays Biochem 64:443–462

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN (2004) Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci U S A 101:15178–15183

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cyrus T, Sung S, Zhao L, Funk CD, Tang S, Praticò D (2002) Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 106:1282–1287

Article  CAS  PubMed  Google Scholar 

DE Matteis R, Flak MB, Gonzalez-Nunez M, Austin-Williams S, Palmas F, Colas RA, Dalli J (2022) Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer. Sci Adv 8:eabl5420

Article  PubMed  PubMed Central  Google Scholar 

Dorrington MG, Fraser IDC (2019) NF-kappaB signaling in macrophages: dynamics, crosstalk, and signal integration. Front Immunol 10:705

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dovizio M, Bruno A, Tacconelli S, Patrignani P (2013) Mode of action of aspirin as a chemopreventive agent. Recent Results Cancer Res 191:39–65

Article  CAS  PubMed  Google Scholar 

Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL et al (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med 324:781–788

Article  CAS  PubMed  Google Scholar 

Elwood PC, Morgan G, Pickering JE, Galante J, Weightman AL, Morris D, Kelson M, Dolwani S (2016) Aspirin in the treatment of cancer: reductions in metastatic spread and in mortality: a systematic review and meta-analyses of published studies. PLoS ONE 11:e0152402

Article  PubMed  PubMed Central  Google Scholar 

Forssell J, Oberg A, Henriksson ML, Stenling R, Jung A, Palmqvist R (2007) High macrophage infiltration along the tumor front correlates with improved survival in colon cancer. Clin Cancer Res 13:1472–1479

Article  CAS  PubMed  Google Scholar 

Gilligan MM, Gartung A, Sulciner ML, Norris PC, Sukhatme VP, Bielenberg DR, Huang S, Kieran MW, Serhan CN, Panigrahy D (2019) Aspirin-triggered proresolving mediators stimulate resolution in cancer. Proc Natl Acad Sci U S A 116:6292–6297

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grancher A, Michel P, DI Fiore F, Sefrioui D (2022) Colorectal cancer chemoprevention: is aspirin still in the game? Cancer Biol Ther 23:446–461

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo Y, Liu Y, Zhang C, Su ZY, Li W, Huang MT, Kong AN (2016) The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice. Carcinogenesis 37:616–624

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, Zeng C, Zhou T, Zhang J (2024) NF-kappaB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther 9:53

Article  CAS  PubMed  PubMed Central  Google Scholar 

Javeed A, Hou Y, Duan K, Zhang B, Shen H, Cao Y, Zhao Y (2011) Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice. Inflamm Res 60:389–398

Article  CAS  PubMed  Google Scholar 

Jiang W, Yan Y, Chen M, Luo G, Hao J, Pan J, Hu S, Guo P, Li W, Wang R, Zuo Y, Sun Y, Sui S, Yu W, Pan Z, Zou K, Zheng Z, Deng W, Wu X, Guo W (2020) Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-kappaB to the COX-2 promoter. Aging (Albany NY) 12:611–627

Article  CAS  PubMed  Google Scholar 

Kata D, Foldesi I, Feher LZ, Hackler LJR, Puskas LG, Gulya K (2017) A novel pleiotropic effect of aspirin: beneficial regulation of pro- and anti-inflammatory mechanisms in microglial cells. Brain Res Bull 132:61–74

Article  CAS  PubMed  Google Scholar 

Khoshbin E, Salehi R, Behroozi R, Sadr S, Zamani A, Farhadian M, Karkehabadi H (2023) The effect of low-dose aspirin on aspirin triggered lipoxin, interleukin 1 beta, and prostaglandin E2 levels in periapical fluid: a double-blind randomized clinical trial. BMC Oral Health 23:530

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kutuk O, Basaga H (2004) Aspirin inhibits TNFalpha- and IL-1-induced NF-kappaB activation and sensitizes HeLa cells to apoptosis. Cytokine 25:229–237

Article  CAS  PubMed  Google Scholar 

Labelle M, Begum S, Hynes RO (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20:576–590

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1:a001651

Article  PubMed  PubMed Central  Google Scholar 

Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, Sun R, Nosho K, Meyerhardt JA, Giovannucci E, Fuchs CS, Chan AT, Ogino S (2012) Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 367:1596–1606

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lichtenberger LM, Vijayan KV (2019) Are platelets the primary target of Aspirin’s remarkable anticancer activity? Cancer Res 79:3820–3823

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Fang S, Li X, Feng J, Du J, Guo L, Su Y, Zhou J, Ding G, Bai Y, Wang S, Wang H, Liu Y (2017) Aspirin inhibits LPS-induced macrophage activation via the NF-kappaB pathway. Sci Rep 7:11549

Article