Cannabinoids in preclinical research of sepsis: a scoping review

Maccarrone M, Di Marzo V, Gertsch J, et al. Goods and bads of the endocannabinoid system as a therapeutic target: lessons learned after 30 years. Pharmacol Rev. 2023;75(5):885–958.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Petrocellis L, Di Marzo V. An introduction to the endocannabinoid system: from the early to the latest concepts. Best Pract Res Clin Endocrinol Metab. 2009;23(1):1–15.

Article  PubMed  Google Scholar 

Kogan NM, Mechoulam R. The chemistry of endocannabinoids. J Endocrinol Invest. 2006;29(3 Suppl):3–14.

CAS  PubMed  Google Scholar 

Lu HC, Mackie K. Review of the endocannabinoid system. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;6(6):607–15.

PubMed  Google Scholar 

Atwood BK, Mackie K. CB2: a cannabinoid receptor with an identity crisis. Br J Pharmacol. 2010;160(3):467–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang S, Fu Y, Williams J, et al. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS ONE. 2007;2(7):e641.

Article  PubMed  PubMed Central  Google Scholar 

Maccarrone M, Finazzi-Agró A. The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell Death Differ. 2003;10(9):946–55.

Article  CAS  PubMed  Google Scholar 

Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hajj J, Blaine N, Salavaci J, Jacoby D. The, “centrality of sepsis”: a review on incidence, mortality, and cost of care. Healthcare. 2018;6(3):90.

Article  PubMed  PubMed Central  Google Scholar 

Polat G, Ugan RA, Cadirci E, Halici Z. Sepsis and septic shock: current treatment strategies and new approaches. Eurasian J Med. 2017;49(1):53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marshall JC. Why have clinical trials in sepsis failed? Trends Mol Med. 2014;20(4):195–203.

Article  PubMed  Google Scholar 

Ladak N, Beishon L, Thompson JP, Lambert DG. Cannabinoids and sepsis. Trends Anaesth Crit Care. 2011;1(4):191–8.

Google Scholar 

Lehmann C, Kianian M, Zhou J, et al. The endocannabinoid system in sepsis–a potential target to improve microcirculation? Signa Vitae. 2011;6(1):7–13.

Article  CAS  Google Scholar 

Leite-Avalca MCG, Zampronio A, Lehmann C. Cannabinoid receptor 1 and 2 signaling pathways involved in sepsis. Shock. 2021;56(5):673–81.

Article  CAS  PubMed  Google Scholar 

Pacher P, Mukhopadhyay P, Mohanraj R, et al. Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations. Hypertension. 2008;52(4):601–7.

Article  CAS  PubMed  Google Scholar 

Lafreniere JD, Lehmann C. Parameters of the endocannabinoid system as novel biomarkers in sepsis and septic shock. Metabolites. 2017;7(4):55.

Article  PubMed  PubMed Central  Google Scholar 

Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.

Article  PubMed  Google Scholar 

Klein TW, Newton C, Friedman H. Cannabinoids and immunity to Legionella pneumophila infection. AIDS, Drugs of Abuse, and the Neuroimmune Axis. 1996;402:103–9.

Article  CAS  Google Scholar 

Varga K, Wagner JA, Bridgen DT, et al. Platelet-and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J. 1998;12(11):1035–44.

Article  CAS  PubMed  Google Scholar 

Gardiner SM, March JE, Kemp PA, et al. Involvement of CB1-receptors and β-adrenoceptors in the regional hemodynamic responses to lipopolysaccharide infusion in conscious rats. American Journal of Physiology-Heart and Circulatory Physiology. 2005;288(5):H2280–8.

Article  CAS  PubMed  Google Scholar 

Kadoi Y, Hinohara H, Kunimoto F, et al. Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. Crit Care Med. 2005;33(11):2629–36.

Article  CAS  PubMed  Google Scholar 

Kadoi Y, Hinohara H, Kunimoto F, et al. Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats. Br J Anaesth. 2005;94(5):563–8.

Article  CAS  PubMed  Google Scholar 

Benamar K, Yondorf M, Meissler JJ, et al. A novel role of cannabinoids: implication in the fever induced by bacterial lipopolysaccharide. J Pharmacol Exp Ther. 2007;320(3):1127–33.

Article  CAS  PubMed  Google Scholar 

Orliac ML, Peroni RN, Abramoff T, et al. Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats. Eur J Pharmacol. 2007;566(1–3):145–52.

Article  CAS  PubMed  Google Scholar 

De Filippis D, Iuvone T, D’amico A, et al. Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB1 receptors and fatty acid amide hydrolase. Neurogastroenterol Motil. 2008;20(8):919–27.

Article  PubMed  Google Scholar 

Hashiguchi T, Kakihana Y, Isowaki S, et al. Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia. J Anesth. 2008;22(3):213–20.

Article  PubMed  Google Scholar 

Kadoi Y, Hinohara H, Kunimoto F, et al. Effects of the cannabinoid antagonist AM281 on systemic hemodynamics and mortality rate in streptozotocin-induced diabetic rats with endotoxic shock: comparison between non-diabetic and diabetic rats. Acta Anaesthesiol Scand. 2008;52(5):664–72.

Article  CAS  PubMed  Google Scholar 

Godlewski G, Malinowska B, Schlicker E. Presynaptic cannabinoid CB1 receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats. Br J Pharmacol. 2004;142(4):701–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Csóka B, Németh ZH, Mukhopadhyay P, et al. CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis. PLoS ONE. 2009;4(7):e6409.

Article  PubMed  PubMed Central  Google Scholar 

Tschöp J, Kasten KR, Nogueiras R, et al. The cannabinoid receptor 2 is critical for the host response to sepsis. J Immunol. 2009;183(1):499–505.

Article  PubMed  Google Scholar 

Vercelli CA, Aisemberg J, Billi S, et al. Endocannabinoid system and nitric oxide are involved in the deleterious effects of lipopolysaccharide on murine decidua. Placenta. 2009;30(7):579–84.

Article  CAS  PubMed  Google Scholar 

Villanueva A, Yilmaz SM, Millington WR, et al. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Shock. 2009;32(6):614–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cassol-Jr OJ, Comim CM, Silva BR, et al. Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture. Brain Res. 2010;1348:128–38.

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