Tuberculosis-infected macrophage exosomal miR-125b-5p induces osteoporosis by targeting IGF2 through the PI3K/AKT pathway

Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet. 2011;377(9773):1276–87.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cosman F, et al. Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25(10):2359–81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Compston JE, McClung MR, Leslie WD. Osteoporosis. Lancet. 2019;393(10169):364–76.

Article  PubMed  CAS  Google Scholar 

Kanis JA, et al. SCOPE 2021: a new scorecard for osteoporosis in Europe. Archives Osteoporos. 2020;15(1):82.

Article  Google Scholar 

Bagcchi S. WHO’s global tuberculosis report 2022. Lancet Microbe. 2023;4(1):e20.

Article  PubMed  Google Scholar 

Ma W, Jin W, He X, Sun Y, Yin H, Wang Z, et al. Mycobacterium tuberculosis induced osteoblast dysregulation involved in bone destruction in spinal tuberculosis. Front Cell Infect Microbiol. 2022;12:780272.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen YY, Feng JY, Ting WY, et al. Increased risk of incident osteoporosis and osteoporotic fracture in tuberculosis patients: a population-based study in a tuberculosis-endemic area. Osteoporos Int. 2017;28(5):1711–21. https://doi.org/10.1007/s00198-017-3939-x.

Article  PubMed  Google Scholar 

Choi H, Shin J, Jung JH, et al. Tuberculosis and osteoporotic fracture risk: development of individualized fracture risk estimation prediction model using a nationwide cohort study. Front Public Health. 2024;12:1358010. https://doi.org/10.3389/fpubh.2024.1358010.

Article  PubMed  PubMed Central  Google Scholar 

Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44(3):450–62.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lei F, Li M, Lin T, Zhou H, Wang F, Su X. Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes. Acta Biomater. 2022;141:333–43.

Article  PubMed  CAS  Google Scholar 

Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hwang JH, Park YS, Kim HS, Kim DH, Lee SH, Lee CH, et al. Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice. J Control Release. 2023;355:184–98.

Article  PubMed  CAS  Google Scholar 

Jie J, Xu X, Li W, Wang G. Regulation of apoptosis and inflammatory response in Interleukin-1β-Induced nucleus pulposus cells by miR-125b-5p via targeting TRIAP1. Biochem Genet. 2021;59(2):475–90.

Article  PubMed  CAS  Google Scholar 

Laviola L, Natalicchio A, Giorgino F. The IGF-I signaling pathway. Curr Pharm Des. 2007;13(7):663–9.

Article  PubMed  CAS  Google Scholar 

Clemmons DR. Role of IGF-binding proteins in regulating IGF responses to changes in metabolism. J Mol Endocrinol. 2018;61(1):T139–69.

Article  PubMed  CAS  Google Scholar 

Chen M, Liang H, Wu M, Ge H, Ma Y, Shen Y, et al. Fgf9 regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis by PI3K/AKT/Hippo and MEK/ERK signaling. Int J Biol Sci. 2024;20(9):3461–79.

Article  PubMed  PubMed Central  Google Scholar 

Manning BD, Toker A. AKT/PKB signaling: navigating the network. Cell. 2017;169(3):381–405.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Deng S, Dai G, Chen S, Nie Z, Zhou J, Fang H, et al. Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway. Biomed Pharmacother. 2019;110:602–8.

Article  PubMed  CAS  Google Scholar 

Sun Z, Pang X, Wang X, Zeng H. Differential expression analysis of miRNAs in macrophage-derived exosomes in the tuberculosis-infected bone microenvironment. Front Microbiol. 2023;14:1236012. https://doi.org/10.3389/fmicb.2023.1236012.

Article  PubMed  PubMed Central  Google Scholar 

Park SH, Yoon SR, Nam JY, Ahn JY, Jeong SJ, Ku NS, et al. Impact of tuberculosis on the incidence of osteoporosis and osteoporotic fractures: a nationwide population-based cohort study. Public Health. 2023;216:13–20.

Article  PubMed  CAS  Google Scholar 

Wu J, Zhang Y, Li W, Tang H, Zhou Y, You D, et al. Mycobacterium tuberculosis suppresses inflammatory responses in host through its cholesterol metabolites. ACS Infect Dis. 2024;10(10):3650–63.

Article  PubMed  CAS  Google Scholar 

Geneviève N, Mojgan Y, Nahid Y, Vincenzo F, Simon G, Daniel S, et al. Genetic susceptibility and late bone outcomes in childhood acute lymphoblastic leukemia survivors. J Bone Min Res. 2024;39(2):130–8.

Article  Google Scholar 

.Dahl J, Holvik K, Heldal E, et al. Individual variation in adaptive immune responses and risk of hip Fracture-A NOREPOS Population-Based cohort study. J Bone Min Res. 2020;35(12):2327–34. https://doi.org/10.1002/jbmr.4135.

Article  CAS  Google Scholar 

.Khan N, Downey J, Sanz J, et al. M. tuberculosis reprograms hematopoietic stem cells to limit myelopoiesis and impair trained immunity. Cell. 2020;183(3):752–e77022. https://doi.org/10.1016/j.cell.2020.09.062.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Corr PD. Musculoskeletal fungal infections. Semin Musculoskelet Radiol. 2011;15(5):506–10.

Article  PubMed  Google Scholar 

Deng J, Sun D, Luo F, Zhang Q, Chen F, Xu J, et al. Anti-IFN-γ antibody promotes osteoclastogenesis in human bone marrow monocyte-derived macrophages co-cultured with tuberculosis-activated Th1 cells. Cell Physiol Biochem. 2018;49(4):1512–22.

Article  PubMed  CAS  Google Scholar 

Dunn RN, Ben Husien M. Spinal tuberculosis: review of current management. Bone Joint J. 2018;100–B(4):425–31.

Article  PubMed  Google Scholar 

Iantomasi T, Romagnoli C, Palmini G, Donati S, Falsetti I, Miglietta F, et al. Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with MicroRNAs. Int J Mol Sci. 2023;24(4):3772.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jafari R, Rahbarghazi R, Ahmadi M, Hassanpour M, Rezaie J. Hypoxic exosomes orchestrate tumorigenesis: molecular mechanisms and therapeutic implications. J Transl Med. 2020;18(1):474. https://doi.org/10.1186/s12967-020-02662-9.

Article  PubMed  PubMed Central  Google Scholar 

Goettsch C, Rauner M, Pacyna N, Hempel U, Bornstein SR, Hofbauer LC. miR-125b regulates calcification of vascular smooth muscle cells. Am J Pathol. 2011;179(4):1594–600. https://doi.org/10.1016/j.ajpath.2011.06.016.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen X, Wang Z, Duan N, Zhu G, Schwarz EM, Xie C. Osteoblast-osteoclast interactions. Connect Tissue Res. 2018;59(2):99–107.

Article 

Comments (0)

No login
gif