Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization in diabetic db/db mice: a magnetic resonance imaging-based study

Akram R, Anwar H, Javed MS, Rasul A, Imran A, Malik SA, Raza C, Khan IU, Sajid F, Iman T, Sun T, Han HS, Hussain G (2022) Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets. Biomedicines 10. https://doi.org/10.3390/biomedicines10123186.

Alotaibi A, Tench C, Stevenson R, Felmban G, Altokhis A, Aldhebaib A, Dineen RA, Constantinescu CS (2021) Investigating brain microstructural alterations in type 1 and type 2 diabetes using diffusion tensor imaging: a systematic review. Brain Sci 11:140. https://doi.org/10.3390/brainsci11020140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Callisaya ML, Beare R, Moran C, Phan T, Wang W, Srikanth VK (2019) Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study. Diabetologia 62:448–458. https://doi.org/10.1007/s00125-018-4778-9

Article  PubMed  Google Scholar 

Dhaliwal J, Dhaliwal N, Akhtar A, Kuhad A, Chopra K (2022) Tetramethylpyrazine attenuates cognitive impairment via suppressing oxidative stress, neuroinflammation, and apoptosis in type 2 Diabetic rats. Neurochem Res 47:2431–2444. https://doi.org/10.1007/s11064-022-03640-x

Article  CAS  PubMed  Google Scholar 

Gao S, Chen Y, Sang F, Yang Y, Xia J, Li X, Zhang J, Chen K, Zhang Z (2019) White matter microstructural change contributes to worse cognitive function in patients with type 2 diabetes. Diabetes 68:2085–2094. https://doi.org/10.2337/db19-0233

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grosu S, Lorbeer R, Hartmann F, Rospleszcz S, Bamberg F, Schlett CL, Galie F, Selder S, Auweter S, Heier M, Rathmann W, Mueller-Peltzer K, Ladwig KH, Peters A, Ertl-Wagner BB, Stoecklein S (2021) White matter hyperintensity volume in pre-diabetes, diabetes and normoglycemia. BMJ Open Diabetes Res Care 9. https://doi.org/10.1136/bmjdrc-2020-002050

Habtemariam S (2020) Berberine pharmacology and the gut microbiota: a hidden therapeutic link. Pharmacol Res 155:104722. https://doi.org/10.1016/j.phrs.2020.104722

Article  CAS  PubMed  Google Scholar 

Hu X, Zhang Y, Xue Y, Zhang Z, Wang J (2018) Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation. Am J Transl Res 10:3322–3329

CAS  PubMed  PubMed Central  Google Scholar 

Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wolfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Gotz J (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models. Cell 142:387–397. https://doi.org/10.1016/j.cell.2010.06.036

Article  CAS  PubMed  Google Scholar 

Jing J, Zhou Y, Pan Y, Cai X, Zhu W, Zhang Z, Li Z, Liu C, Meng X, Cheng J, Wang Y, Li H, Wu Z, Wang S, Niu H, Wen W, Liu T, Wei T, Wang Y, Sachdev PS (2022) Reduced white matter microstructural integrity in prediabetes and diabetes: a population-based study. EBioMedicine 82:104144. https://doi.org/10.1016/j.ebiom.2022.104144

Article  CAS  PubMed  PubMed Central  Google Scholar 

King MR, Anderson NJ, Guernsey LS, Jolivalt CG (2013) Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice. J Neurosci Res 91:506–514. https://doi.org/10.1002/jnr.23192

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li XL, Aou S, Oomura Y, Hori N, Fukunaga K, Hori T (2002) Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 113:607–615. https://doi.org/10.1016/s0306-4522(02)00162-8

Article  CAS  PubMed  Google Scholar 

Li HY, Wang XC, Xu YM, Luo NC, Luo S, Hao XY, Cheng SY, Fang JS, Wang Q, Zhang SJ, Chen YB (2018) Berberine improves diabetic encephalopathy through the SIRT1/ER stress pathway in db/db mice. Rejuvenation Res 21:200–209. https://doi.org/10.1089/rej.2017.1972

Article  CAS  PubMed  Google Scholar 

Liang Y, Xu X, Yin M, Zhang Y, Huang L, Chen R, Ni J (2019) Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J 66:51–63. https://doi.org/10.1507/endocrj.EJ18-0109

Article  CAS  PubMed  Google Scholar 

Liu J, Liu T, Wang W, Ma L, Ma X, Shi S, Gong Q, Wang M (2017) Reduced gray matter volume in patients with type 2 diabetes mellitus. Front Aging Neurosci 9:161. https://doi.org/10.3389/fnagi.2017.00161

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma T, Li ZY, Yu Y, Hu B, Han Y, Ni MH, Huang YX, Chen HH, Wang W, Yan LF, Cui GB (2022) Gray and white matter abnormality in patients with T2DM-related cognitive dysfunction: a systemic review and meta-analysis. Nutr Diabetes 12:39. https://doi.org/10.1038/s41387-022-00214-2

Article  PubMed  PubMed Central  Google Scholar 

Peltier J, Roussel M, Gerard Y, Lassonde M, Deramond H, Le Gars D, De Beaumont L, Godefroy O (2012) Functional consequences of a section of the anterior part of the body of the corpus callosum: evidence from an interhemispheric transcallosal approach. J Neurol 259:1860–1867. https://doi.org/10.1007/s00415-012-6421-x

Article  PubMed  Google Scholar 

Pu K, Wu M, Jiang T, Zhang Y, Ye M, Sun J, Ma H, Zhai Q, Wang Q (2022) Involvement of paired immunoglobulin-like receptor B in diabetes-associated cognitive dysfunction through modulation of axon outgrowth and dendritic remodeling. Mol Neurobiol 59:2563–2579. https://doi.org/10.1007/s12035-021-02679-1

Article  CAS  PubMed  Google Scholar 

Qiu Q, Lei X, Wang Y, Xiong H, Xu Y, Sun H, Xu H, Zhang N (2023) Naringin protects against tau hyperphosphorylation in abeta (25–35)-Injured PC12 cells through modulation of ER, PI3K/AKT, and GSK-3beta signaling pathways. Behav Neurol 2023:1857330. https://doi.org/10.1155/2023/1857330

Ramos-Rodriguez JJ, Ortiz O, Jimenez-Palomares M, Kay KR, Berrocoso E, Murillo-Carretero MI, Perdomo G, Spires-Jones T, Cozar-Castellano I, Lechuga-Sancho AM, Garcia-Alloza M (2013) Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice. Psychoneuroendocrinology 38:2462–2475. https://doi.org/10.1016/j.psyneuen.2013.05.010

Article  PubMed  Google Scholar 

Roland JL, Snyder AZ, Hacker CD, Mitra A, Shimony JS, Limbrick DD, Raichle ME, Smyth MD, Leuthardt EC (2017) On the role of the corpus callosum in interhemispheric functional connectivity in humans. Proc Natl Acad Sci U S A 114:13278–13283. https://doi.org/10.1073/pnas.1707050114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sandrone S, Aiello M, Cavaliere C, Thiebaut de Schotten M, Reimann K, Troakes C, Bodi I, Lacerda L, Monti S, Murphy D, Geyer S, Catani M, Dell’Acqua F (2023) Mapping myelin in white matter with T1-weighted/T2-weighted maps: discrepancy with histology and other myelin MRI measures. Brain Struct Funct 228:525–535. https://doi.org/10.1007/s00429-022-02600-z

Article  PubMed  PubMed Central  Google Scholar 

Srikanth V, Sinclair AJ, Hill-Briggs F, Moran C, Biessels GJ (2020) Type 2 diabetes and cognitive dysfunction-towards effective management of both comorbidities. Lancet Diabetes Endocrinol 8:535–545. https://doi.org/10.1016/S2213-8587(20)30118-2

Article  PubMed  Google Scholar 

Takahashi-Yanaga F (2013) Activator or inhibitor? GSK-3 as a new drug target. Biochem Pharmacol 86:191–199. https://doi.org/10.1016/j.bcp.2013.04.022

Article  CAS  PubMed  Google Scholar 

Tian L, Ri H, Qi J, Fu P (2021) Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy. Mol Pain 17:1744806921996101. https://doi.org/10.1177/1744806921996101

Article  CAS  PubMed  PubMed Central  Google Scholar 

Udagawa J, Hashimoto R, Suzuki H, Hatta T, Sotomaru Y, Hioki K, Kagohashi Y, Nomura T, Minami Y, Otani H (2006) The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology 147:647–658. https://doi.org/10.1210/en.2005-0791

Article  CAS  PubMed  Google Scholar 

Wang X, Zhao L (2016) Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3beta signaling pathway. Biochem Biophys Res Commun 473:428–434. https://doi.org/10.1016/j.bbrc.2016.03.024

Article  CAS  PubMed  Google Scholar 

Wang Z, Huang Y, Cheng Y, Tan Y, Wu F, Wu J, Shi H, Zhang H, Yu X, Gao H, Lin L, Cai J, Zhang J, Li X, Cai L, Xiao J (2016) Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy. Oncotarget 7:78455–78472. https://doi.org/10.18632/oncotarget.12925

Article  PubMed  PubMed Central 

Comments (0)

No login
gif