Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Klatte T, Rossi SH, Stewart GD. Prognostic factors and prognostic models for renal cell carcinoma: a literature review. World J Urol. 2018;36(12):1943–52.

Article  PubMed  Google Scholar 

Müller SD, Ziegler JSH, Piegeler T. Local anesthetics and recurrence after cancer surgery-what’s new? a narrative review. J Clin Med. 2021;10(4):719.

Article  PubMed  PubMed Central  Google Scholar 

Bharati SJ, et al. Anesthetics impact on cancer recurrence: what do we know? J Cancer Res Ther. 2016;12(2):464–8.

Article  CAS  PubMed  Google Scholar 

Ni J, et al. Amide-linked local anesthetics preferentially target leukemia stem cell through inhibition of wnt/β-catenin. Biochem Biophys Res Commun. 2018;503(2):956–62.

Article  CAS  PubMed  Google Scholar 

Wang W, et al. Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity. Biol Res. 2019;52(1):36.

Article  PubMed  PubMed Central  Google Scholar 

Dan J, et al. Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade. Biomed Pharmacother. 2018;103:823–8.

Article  CAS  PubMed  Google Scholar 

Piegeler T, et al. Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase. Br J Anaesth. 2015;115(5):784–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng Q, Peng X, Yu H. Local anesthetic drug inhibits growth and survival in chronic myeloid leukemia through suppressing PI3K/Akt/mTOR. Am J Med Sci. 2018;355(3):266–73.

Article  PubMed  Google Scholar 

Li C, et al. Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA. Oncol Res. 2018;26(2):209–17.

Article  PubMed  PubMed Central  Google Scholar 

Simpson D, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675–717.

Article  CAS  PubMed  Google Scholar 

Wang X, Li T. Ropivacaine inhibits the proliferation and migration of colorectal cancer cells through ITGB1. Bioengineered. 2021;12(1):44–53.

Article  CAS  PubMed  Google Scholar 

Zhang N, et al. Ropivacaine Inhibits the Growth, Migration and Invasion of Gastric Cancer Through Attenuation of WEE1 and PI3K/AKT Signaling via miR-520a-3p. Onco Targets Ther. 2020;13:5309–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bridges MC, Daulagala AC, Kourtidis A. LNCcation: lncRNA localization and function. J Cell Biol. 2021;220(2):e202009045.

Bhan A, Soleimani M, Mandal SS. Long noncoding RNA and cancer: a new paradigm. Cancer Res. 2017;77(15):3965–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, et al. Potential role of lncRNA H19 as a cancer biomarker in human cancers detection and diagnosis: A Pooled Analysis Based on 1585 Subjects. Biomed Res Int. 2019;2019:9056458.

PubMed  PubMed Central  Google Scholar 

Liu S, et al. Identification of the 3-lncRNA signature as a prognostic biomarker for colorectal cancer. Int J Mol Sci. 2020;21(24):9359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hussen BM, et al. Long non-coding RNA RMRP in the pathogenesis of human disorders. Front Cell Dev Biol. 2021;9:676588.

Article  PubMed  PubMed Central  Google Scholar 

Cao HL, et al. lncRNA-RMRP promotes proliferation, migration and invasion of bladder cancer via miR-206. Eur Rev Med Pharmacol Sci. 2019;23(3):1012–21.

PubMed  Google Scholar 

Hongfeng Z, et al. lncRNA RMRP knockdown suppress hepatocellular carcinoma biological activities via regulation miRNA-206/TACR1. J Cell Biochem. 2020;121(2):1690–702.

Article  PubMed  Google Scholar 

Bachmann IM, et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol. 2006;24(2):268–73.

Article  CAS  PubMed  Google Scholar 

Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469(7330):343–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hui B, et al. RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4. Cell Death Dis. 2019;10(3):207.

Article  PubMed  PubMed Central  Google Scholar 

Priyanka PP, Yenugu S. Coiled-coil domain-containing (CCDC) proteins: functional roles in general and male reproductive physiology. Reprod Sci. 2021;28(10):2725–34.

Article  PubMed  Google Scholar 

Liu Z, et al. Regulatory network and targeted interventions for CCDC family in tumor pathogenesis. Cancer Lett. 2023;565: 216225.

Article  CAS  PubMed  Google Scholar 

Deng T, et al. CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer. Theranostics. 2021;11(16):8112–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, et al. CCDC65, a gene knockout that leads to early death of mice, acts as a potentially novel tumor suppressor in lung adenocarcinoma. Int J Biol Sci. 2022;18(10):4171–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Le Gac G, et al. Local anesthetics inhibit the growth of human hepatocellular carcinoma cells. Anesth Analg. 2017;125(5):1600–9.

Article  PubMed  Google Scholar 

Zhang Y, et al. Mechanisms of cancer inhibition by local anesthetics. Front Pharmacol. 2021;12: 770694.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu P, et al. Local anesthetic ropivacaine exhibits therapeutic effects in cancers. Front Oncol. 2022;12: 836882.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charles Richard JL, Eichhorn PJA. Platforms for investigating LncRNA functions. SLAS Technol. 2018;23(6):493–506.

Article  PubMed  PubMed Central  Google Scholar 

Liu R, et al. Ropivacaine inhibits proliferation, migration, and invasion while inducing apoptosis of glioma cells by regulating the SNHG16/miR-424-5p axis. Open Life Sci. 2020;15(1):988–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, et al. Ropivacaine retards the viability, migration, and invasion of choriocarcinoma cells by regulating the long noncoding RNA OGFRP1/MicroRNA-4731-5p/HIF3A axis. Mol Biotechnol. 2022;64(5):499–509.

Article  CAS  PubMed  Google Scholar 

Xie Z, et al. lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis. Bioengineered. 2021;12(1):6913–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang M, Ke H, Zhou W. LncRNA RMRP promotes cell proliferation and invasion through miR-613/NFAT5 axis in non-small cell lung cancer. Onco Targets Ther. 2020;13:8941–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

da Rocha ST, et al. Jarid2 is implicated in the initial xist-induced targeting of PRC2 to the inactive X chromosome. Mol Cell. 2014;53(2):301–16.

Article  PubMed  Google Scholar 

Laugesen A, Højfeldt JW, Helin K. Molecular mechanisms directing PRC2 recruitment and H3K27 methylation. Mol Cell. 2019;74(1):8–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, et al. A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia. Oncogene. 2020;39(9):1860–74.

Article  CAS  PubMed