(2019) The Gene Ontology Resource: 20 years and still GOing strong. Nucleic acids Res 47(D1):D330-d338. https://doi.org/10.1093/nar/gky1055

Andrade RM, Alarcón GS, González LA, Fernández M, Apte M, Vilá LM et al (2008) Seizures in patients with systemic lupus erythematosus: data from LUMINA, a multiethnic cohort (LUMINA LIV). Ann Rheum Dis 67(6):829–834. https://doi.org/10.1136/ard.2007.077594

Article  CAS  PubMed  Google Scholar 

Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet JM, Sato K et al (2004) Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med 199(8):1121–1131. https://doi.org/10.1084/jem.20031557

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arikawa T, Watanabe K, Seki M, Matsukawa A, Oomizu S, Sakata KM et al (2009) Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages. Clin Immunol (orlando Fla) 133(3):382–392. https://doi.org/10.1016/j.clim.2009.09.004

Article  CAS  Google Scholar 

Aristoteli LP, Møller HJ, Bailey B, Moestrup SK, Kritharides L (2006) The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis. Atherosclerosis 184(2):342–347. https://doi.org/10.1016/j.atherosclerosis.2005.05.004

Article  CAS  PubMed  Google Scholar 

Atzeni F, Pipitone N, Iaccarino L, Masala IF, Weiss R, Alciati A et al (2017) Rheumatic diseases and autoimmune vascular dementia. Autoimmun Rev 16(12):1265–1269. https://doi.org/10.1016/j.autrev.2017.10.011

Article  PubMed  Google Scholar 

Briani C, Lucchetta M, Ghirardello A, Toffanin E, Zampieri S, Ruggero S et al (2009) Neurolupus is associated with anti-ribosomal P protein antibodies: an inception cohort study. J Autoimmun 32(2):79–84. https://doi.org/10.1016/j.jaut.2008.12.002

Article  CAS  PubMed  Google Scholar 

Denny MF, Thacker S, Mehta H, Somers EC, Dodick T, Barrat FJ et al (2007) Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood 110(8):2907–2915. https://doi.org/10.1182/blood-2007-05-089086

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA et al (2008) Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol 7(10):875–884. https://doi.org/10.1016/s1474-4422(08)70198-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND et al (2020) Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nat Biotechnol 38(6):737–746. https://doi.org/10.1038/s41587-020-0465-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ellis K, Kerr J, Godbole S, Lanckriet G, Wing D, Marshall S (2014) A random forest classifier for the prediction of energy expenditure and type of physical activity from wrist and hip accelerometers. Physiol Meas 35(11):2191–2203. https://doi.org/10.1088/0967-3334/35/11/2191

Article  PubMed  PubMed Central  Google Scholar 

Eslami M, Nezafat N, Negahdaripour M, Ghasemi Y (2019) Computational approach to suggest a new multi-target-directed ligand as a potential medication for Alzheimer’s disease. J Biomol Struct Dyn 37(18):4825–4839. https://doi.org/10.1080/07391102.2018.1564701

Article  CAS  PubMed  Google Scholar 

Fabriek BO, Van Haastert ES, Galea I, Polfliet MM, Döpp ED, Van Den Heuvel MM et al (2005) CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation. Glia 51(4):297–305. https://doi.org/10.1002/glia.20208

Article  PubMed  Google Scholar 

Finger CE, Moreno-Gonzalez I, Gutierrez A, Moruno-Manchon JF, McCullough LD (2022) Age-related immune alterations and cerebrovascular inflammation. Mol Psychiatry 27(2):803–818. https://doi.org/10.1038/s41380-021-01361-1

Article  CAS  PubMed  Google Scholar 

Galea I, Felton LM, Waters S, van Rooijen N, Perry VH, Newman TA (2008) Immune-to-brain signalling: the role of cerebral CD163-positive macrophages. Neurosci Lett 448(1):41–46. https://doi.org/10.1016/j.neulet.2008.09.081

Article  CAS  PubMed  Google Scholar 

Greco R, Demartini C, Zanaboni AM, Tumelero E, Persico A, Candeloro E et al (2021) CD163 as a potential biomarker of monocyte activation in ischemic stroke patients. Int J Mol Sci 22(13). https://doi.org/10.3390/ijms22136712

Hanly JG, Su L, Farewell V, McCurdy G, Fougere L, Thompson K (2009) Prospective study of neuropsychiatric events in systemic lupus erythematosus. J Rheumatol 36(7):1449–1459. https://doi.org/10.3899/jrheum.081133

Article  PubMed  Google Scholar 

He XW, Li WL, Li C, Liu P, Shen YG, Zhu M et al (2017) Serum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic stroke. Sci Rep 7:40994. https://doi.org/10.1038/srep40994

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hinterberger M, Fischer P, Zehetmayer S (2016) Incidence of dementia over three decades in the Framingham Heart Study. N Engl J Med 375(1):93. https://doi.org/10.1056/NEJMc1604823

Article  PubMed  Google Scholar 

Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH et al (2021) Inference and analysis of cell-cell communication using Cell Chat. Nat Commun 12(1):1088. https://doi.org/10.1038/s41467-021-21246-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jing Z, Shi C, Zhu L, Xiang Y, Chen P, Xiong Z et al (2015) Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 35(8):1249–1259. https://doi.org/10.1038/jcbfm.2015.55

Article  Google Scholar 

John S, Mishra R (2016) Galectin-9: from cell biology to complex disease dynamics. J Biosci 41(3):507–534. https://doi.org/10.1007/s12038-016-9616-y

Article  CAS  PubMed  Google Scholar 

Kalaria RN (2018) The pathology and pathophysiology of vascular dementia. Neuropharmacology 134(Pt B):226–239. https://doi.org/10.1016/j.neuropharm.2017.12.030

Article  CAS  PubMed  Google Scholar 

Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall K et al (2008) Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol 7(9):812–826. https://doi.org/10.1016/s1474-4422(08)70169-8

Article  PubMed  PubMed Central  Google Scholar 

Kapadia M, Sakic B (2011) Autoimmune and inflammatory mechanisms of CNS damage. Prog Neurobiol 95(3):301–333. https://doi.org/10.1016/j.pneurobio.2011.08.008

Article  CAS  PubMed  Google Scholar 

Kim JY, Kim N, Yenari MA (2015) Mechanisms and potential therapeutic applications of microglial activation after brain injury. CNS Neurosci Ther 21(4):309–319. https://doi.org/10.1111/cns.12360

Article  PubMed  Google Scholar 

Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K et al (2019) Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods 16(12):1289–1296. https://doi.org/10.1038/s41592-019-0619-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langa KM, Larson EB, Crimmins EM, Faul JD, Levine DA, Kabeto MU et al (2017) A comparison of the prevalence of dementia in the United States in 2000 and 2012. JAMA Intern Med 177(1):51–58. https://doi.org/10.1001/jamainternmed.2016.6807

Article  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559. https://doi.org/10.1186/1471-2105-9-559

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee JD, Coulthard LG, Woodruff TM (2019) Complement dysregulation in the central nervous system during development and disease. Semin Immunol 45:101340. https://doi.org/10.1016/j.smim.2019.101340

Article  CAS  PubMed  Google Scholar 

Leung ML, Wang Y, Kim C, Gao R, Jiang J, Sei E et al (2016) Highly multiplexed targeted DNA sequencing from single nuclei. Nat Protoc 11(2):214–235. https://doi.org/10.1038/nprot.2016.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin YR, Chou LC, Chen HC, Liou TH, Huang SW, Lin HW (2016) Increased risk of dementia in patients with systemic lupus erythematosus: a nationwide population-based cohort study. Arthritis Care Res 68(12):1774–1779. https://doi.org/10.1002/acr.22914

Article  Google Scholar 

Lobo A, Launer LJ, Fratiglioni L, Andersen K, Di Carlo A, Breteler MM et al (2000) Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54(11 Suppl 5):S4-9

CAS  PubMed  Google Scholar 

Lood C, Eriksson S, Gullstrand B, Jönsen A, Sturfelt G, Truedsson L et al (2012) Increased C1q, C4 and C3 deposition on platelets in patients with systemic lupus erythematosus–a possible link to venous thrombosis? Lupus 21(13):1423–1432. https://doi.org/10.1177/0961203312457210

Article  CAS  PubMed