An H, Heo JS, Kim P, Lian Z, Lee S, Park J et al (2021) Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells. Cell Death Dis 12(2):159

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ariey-Bonnet J, Carrasco K, Le Grand M, Hoffer L, Betzi S, Feracci M et al (2020) In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor. Mol Oncol 14(12):3083–3099

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernstock JD, Hoffman SE, Kappel AD, Valdes PA, Essayed W, Klinger NV et al (2022) Immunotherapy approaches for the treatment of diffuse midline gliomas. Oncoimmunology 11(1):2124058

Article  PubMed  PubMed Central  Google Scholar 

Cao B, Wang S, Li R, Wang Z, Li T, Zhang Y et al (2022) Xihuang pill enhances anticancer effect of anlotinib by regulating gut microbiota composition and tumor angiogenesis pathway. Biomed Pharmacother 151:113081

Article  CAS  PubMed  Google Scholar 

Chao B, Jiang F, Bai H, Meng P, Wang L, Wang F (2022) Predicting the prognosis of glioma by pyroptosis-related signature. J Cell Mol Med 26(1):133–143

Article  CAS  PubMed  Google Scholar 

Chen P, Li Y, Li N, Shen L, Li Z (2021) Comprehensive analysis of pyroptosis-associated in molecular classification, immunity and prognostic of glioma. Front Genet 12:781538

Article  CAS  PubMed  Google Scholar 

Dong Z, Bian L, Wang M, Wang L, Wang Y (2021) Identification of a pyroptosis-related gene signature for prediction of overall survival in lung adenocarcinoma. J Oncol 2021:6365459

Article  PubMed  PubMed Central  Google Scholar 

Feng Y, Li W, Wang Z, Zhang R, Li Y, Zang L et al (2022) The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis. J Transl Med 20(1):497

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng J, Gao X, Chen X, Tong X, Qian M, Gao H et al (2023) Mechanism of Jinzhen oral liquid against influenza-induced lung injury based on metabonomics and gut microbiome. J Ethnopharmacol 303:115977

Article  CAS  PubMed  Google Scholar 

Fu J, Zhu SH, Xu HB, Xu YQ, Wang X, Wang J et al (2020) Xihuang pill potentiates the anti-tumor effects of temozolomide in glioblastoma xenografts through the Akt/mTOR-dependent pathway. J Ethnopharmacol 261:113071

Article  CAS  PubMed  Google Scholar 

Ge A, Yang K, Deng X, Zhao D, Ge J, Liu L (2022) The efficacy and safety of Xihuang pill/capsule in adjuvant treatment of breast cancer: a systematic review and meta-analysis of 26 randomized controlled trials. J Ethnopharmacol 295:115357

Article  CAS  PubMed  Google Scholar 

Gisina A, Kholodenko I, Kim Y, Abakumov M, Lupatov A, Yarygin K (2022) Glioma stem cells: novel data obtained by single-cell sequencing. Int J Mol Sci 23(22):14224

Gu Y, Cai R, Zhang C, Xue Y, Pan Y, Wang J et al (2019) miR-132-3p boosts caveolae-mediated transcellular transport in glioma endothelial cells by targeting PTEN/PI3K/PKB/Src/Cav-1 signaling pathway. FASEB J 33(1):441–454

Article  CAS  PubMed  Google Scholar 

He H, Yi L, Zhang B, Yan B, Xiao M, Ren J et al (2021) USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway. Int J Biol Sci 17(10):2417–2429

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung SN, Kang YE, Lee GH, Liu L, Oh C, Jin YL et al (2020) Brn3a/Pou4f1 Functions as a tumor suppressor by targeting c-MET/STAT3 signaling in thyroid cancer. J Clin Endocrinol Metab 105(9):dgaa316

Li D, Fan H, Dong J, Sun C, Su Y, Liu J et al (2021) Based on BATMAN-TCM to explore the molecular mechanism of Xihuang pill regulating immune function to treat breast precancerous lesions. Breast Cancer (Dove Med Press) 13:725–742

CAS  PubMed  Google Scholar 

Li J, Wang X, Chen L, Zhang J, Zhang Y, Ren X et al (2022) TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas. Cancer Gene Ther 29(8–9):1117–1129

Article  PubMed  PubMed Central  Google Scholar 

Liu L, Yue Q, Ma J, Liu Y, Zhao T, Guo W et al (2020) POU4F1 promotes the resistance of melanoma to BRAF inhibitors through MEK/ERK pathway activation and MITF up-regulation. Cell Death Dis 11(6):451

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oprita A, Baloi SC, Staicu GA, Alexandru O, Tache DE, Danoiu S et al (2021) Updated Insights on EGFR signaling pathways in glioma. Int J Mol Sci 22(2):587

Ozair A, Bhat V, Alisch RS, Khosla AA, Kotecha RR, Odia Y et al (2023) DNA methylation and histone modification in low-grade gliomas: current understanding and potential clinical targets. Cancers (Basel) 15(4):1342

Pan X, Zhou T, Tai YH, Wang C, Zhao J, Cao Y et al (2011) Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nat Med 17(6):708–714

Article  CAS  PubMed  Google Scholar 

Soejima M, Koda Y (2008) TaqMan-based real-time PCR for genotyping common polymorphisms of haptoglobin (HP1 and HP2). Clin Chem 54(11):1908–1913

Article  CAS  PubMed  Google Scholar 

Su L, Jiang Y, Xu Y, Li X, Gao W, Xu C et al (2018) Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway. Biomed Pharmacother 102:1111–1119

Article  PubMed  Google Scholar 

Tanzhu G, Li N, Li Z, Zhou R, Shen L (2022) Molecular subtypes and prognostic signature of pyroptosis-related lncRNAs in glioma patients. Front Oncol 12:779168

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ et al (2020) Polyphyllin VI induces Caspase-1-mediated pyroptosis via the induction of ROS/NF-kappaB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel) 12(1):193

Wang F, Gu L, Wang Y, Sun D, Zhao Y, Meng Q et al (2022) MicroRNA-122a aggravates intestinal ischemia/reperfusion injury by promoting pyroptosis via targeting EGFR-NLRP3 signaling pathway. Life Sci 307:120863

Article  CAS  PubMed  Google Scholar 

Wei Y, Lan B, Zheng T, Yang L, Zhang X, Cheng L et al (2023) GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis. Nat Commun 14(1):929

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu D, Jia HY, Wei N, Li SJ (2020a) POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway. Biochem Biophys Res Commun 533(3):533–539

Article  CAS  PubMed  Google Scholar 

Wu J, Luo D, Li S (2020) Network pharmacology-oriented identification of key proteins and signaling pathways targeted by Xihuang pill in the treatment of breast cancer. Breast Cancer (Dove Med Press) 12:267–277

CAS  PubMed  Google Scholar 

Xu X, Zhang J, Zhang Z, Wang M, Liu Y, Li X (2020) Systems pharmacology in combination with proteomics reveals underlying mechanisms of Xihuang pill against triple-negative breast cancer. Bioengineered 11(1):1170–1188

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu T, Wu K, Shi J, Ji L, Song X, Tao G et al (2022) LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP. Cell Death Discov 8(1):228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu L, Duan H, Zou Y, Wang J, Liu H, Wang W et al (2023) Xihuang pill-destabilized CD133/EGFR/Akt/mTOR cascade reduces stemness enrichment of glioblastoma via the down-regulation of SOX2. Phytomedicine 114:154764

Article  CAS  PubMed  Google Scholar 

Yang K, Zeng L, Ge A, Bao T, Xu T, Xie X et al (2020) Exploring the regulation mechanism of Xihuang pill, olibanum and beta-Boswellic acid on the biomolecular network of triple-negative breast cancer based on transcriptomics and chemical informatics methodology. Front Pharmacol 11:825

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang K, Wu Z, Zhang H, Zhang N, Wu W, Wang Z et al (2022) Glioma targeted therapy: insight into future of molecular approaches. Mol Cancer 21(1):39

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng Y, Cai Y, Chai P, Mao Y, Chen Y, Wang L et al (2022) Optimization of cancer immunotherapy through pyroptosis: a pyroptosis-related signature predicts survival benefit and potential synergy for immunotherapy in glioma. Front Immunol 13:961933

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Zhang C, Yang Y, Wang G, Wang Z, Liu J et al (2022) Pyroptosis-related gene signature predicts prognosis and indicates immune microenvironment infiltration in glioma. Front Cell Dev Biol 10:862493

Article  PubMed  PubMed Central  Google Scholar