Ackers-Johnson M, Li PY, Holmes AP, O’Brien SM, Pavlovic D, Foo RS (2016) A simplified, langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart. Circ Res 119:909–920. https://doi.org/10.1161/CIRCRESAHA.116.309202

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bennett CG, Riemondy K, Chapnick DA, Bunker E, Liu X, Kuersten S, Yi R (2016) Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration. Nucleic Acids Res 44:3788–3800. https://doi.org/10.1093/nar/gkw207

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhattacharjee A, Hasanain M, Kathuria M, Singh A, Datta D, Sarkar J, Mitra K (2018) Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK. Sci Rep 8:2303. https://doi.org/10.1038/s41598-018-20541-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang KT, Cheng CF, King PC, Liu SY, Wang GS (2017) CELF1 Mediates connexin 43 mRNA degradation in dilated cardiomyopathy. Circ Res 121:1140–1152. https://doi.org/10.1161/CIRCRESAHA.117.311281

Article  CAS  PubMed  Google Scholar 

Chen S, Zhou Y, Chen Y, Gu J (2018) fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34:i884–i890. https://doi.org/10.1093/bioinformatics/bty560

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choudhury NR, de Lima AF, de Andres-Aguayo L, Graf T, Caceres JF, Rappsilber J, Michlewski G (2013) Tissue-specific control of brain-enriched miR-7 biogenesis. Genes Dev 27:24–38. https://doi.org/10.1101/gad.199190.112

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corbett AH (2018) Post-transcriptional regulation of gene expression and human disease. Curr Opin Cell Biol 52:96–104. https://doi.org/10.1016/j.ceb.2018.02.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frangogiannis NG (2021) Cardiac fibrosis. Cardiovasc Res 117:1450–1488. https://doi.org/10.1093/cvr/cvaa324

Article  CAS  PubMed  Google Scholar 

Franklin S, Kimball T, Rasmussen TL, Rosa-Garrido M, Chen H, Tran T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO, Vondriska TM (2016) The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. Am J Physiol Heart Circ Physiol 311:H1234–H1247. https://doi.org/10.1152/ajpheart.00235.2016

Article  PubMed  PubMed Central  Google Scholar 

Froese N, Cordero J, Abouissa A, Trogisch FA, Grein S, Szaroszyk M, Wang Y, Gigina A, Korf-Klingebiel M, Bosnjak B, Davenport CF, Wiehlmann L, Geffers R, Riechert E, Jurgensen L, Boileau E, Lin Y, Dieterich C, Forster R, Bauersachs J, Ola R, Dobreva G, Volkers M, Heineke J (2022) Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication. IScience 25:103965. https://doi.org/10.1016/j.isci.2022.103965

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao C, Wang Y (2020) mRNA metabolism in cardiac development and disease: life after transcription. Physiol Rev 100:673–694. https://doi.org/10.1152/physrev.00007.2019

Article  CAS  PubMed  Google Scholar 

Gao J, Schatton D, Martinelli P, Hansen H, Pla-Martin D, Barth E, Becker C, Altmueller J, Frommolt P, Sardiello M, Rugarli EI (2014) CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins. J Cell Biol 207:213–223. https://doi.org/10.1083/jcb.201403129

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo QQ, Gao J, Wang XW, Yin XL, Zhang SC, Li X, Chi LL, Zhou XM, Wang Z, Zhang QY (2020) RNA-binding protein MSI2 binds to miR-301a-3p and facilitates its distribution in mitochondria of endothelial cells. Front Mol Biosci 7:609828. https://doi.org/10.3389/fmolb.2020.609828

Article  CAS  PubMed  Google Scholar 

Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bomeke K, Batkai S, Thum T (2019) miR-212/132 cluster modulation prevents doxorubicin-mediated atrophy and cardiotoxicity. Mol Ther 27:17–28. https://doi.org/10.1016/j.ymthe.2018.11.004

Article  CAS  PubMed  Google Scholar 

Hentze MW, Castello A, Schwarzl T, Preiss T (2018) A brave new world of RNA-binding proteins. Nat Rev Mol Cell Biol 19:327–341. https://doi.org/10.1038/nrm.2017.130

Article  CAS  PubMed  Google Scholar 

Katz Y, Li F, Lambert NJ, Sokol ES, Tam WL, Cheng AW, Airoldi EM, Lengner CJ, Gupta PB, Yu Z, Jaenisch R, Burge CB (2014) Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state. Elife 3:e03915. https://doi.org/10.7554/eLife.03915

Article  PubMed  PubMed Central  Google Scholar 

Kharas MG, Lengner CJ (2017) Stem cells, cancer, and musashi in blood and guts. Trends Cancer 3:347–356. https://doi.org/10.1016/j.trecan.2017.03.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim D, Paggi JM, Park C, Bennett C, Salzberg SL (2019) Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol 37:907–915. https://doi.org/10.1038/s41587-019-0201-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimura T, Ferran B, Tsukahara Y, Shang Q, Desai S, Fedoce A, Pimentel DR, Luptak I, Adachi T, Ido Y, Matsui R, Bachschmid MM (2019) Production of adeno-associated virus vectors for in vitro and in vivo applications. Sci Rep 9:13601. https://doi.org/10.1038/s41598-019-49624-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Li AQ, Zhou SL, Lv H, Wei P, Yang WT (2020) RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer. J Exp Clin Cancer Res 39:92. https://doi.org/10.1186/s13046-020-01587-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, La Salvia S, Liang Y, Adamiak M, Kohlbrenner E, Jeong D, Chepurko E, Ceholski D, Lopez-Gordo E, Yoon S, Mathiyalagan P, Agarwal N, Jha D, Lodha S, Daaboul G, Phan A, Raisinghani N, Zhang S, Zangi L, Gonzalez-Kozlova E, Dubois N, Dogra N, Hajjar RJ, Sahoo S (2023) Extracellular vesicle-encapsulated adeno-associated viruses for therapeutic gene delivery to the heart. Circulation 148:405–425. https://doi.org/10.1161/CIRCULATIONAHA.122.063759

Article  PubMed  Google Scholar 

Nakamura M, Okano H, Blendy JA, Montell C (1994) Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development. Neuron 13:67–81. https://doi.org/10.1016/0896-6273(94)90460-x

Article  CAS  PubMed  Google Scholar 

Oka SI, Sabry AD, Horiuchi AK, Cawley KM, O’Very SA, Zaitsev MA, Shankar TS, Byun J, Mukai R, Xu X, Torres NS, Kumar A, Yazawa M, Ling J, Taleb I, Saijoh Y, Drakos SG, Sadoshima J, Warren JS (2020) Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1. PLoS ONE 15:e0234913. https://doi.org/10.1371/journal.pone.0234913

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paulus MG, Renner K, Nickel AG, Brochhausen C, Limm K, Zugner E, Baier MJ, Pabel S, Wallner S, Birner C, Luchner A, Magnes C, Oefner PJ, Stark KJ, Wagner S, Maack C, Maier LS, Streckfuss-Bomeke K, Sossalla S, Dietl A (2022) Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. Basic Res Cardiol 117:45. https://doi.org/10.1007/s00395-022-00949-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peoples JN, Saraf A, Ghazal N, Pham TT, Kwong JQ (2019) Mitochondrial dysfunction and oxidative stress in heart disease. Exp Mol Med 51:1–13. https://doi.org/10.1038/s12276-019-0355-7

Article  CAS  PubMed  Google Scholar 

Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT, Salzberg SL (2015) StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol 33:290–295. https://doi.org/10.1038/nbt.3122

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pun-Garcia A, Clemente-Moragon A, Villena-Gutierrez R, Gomez M, Sanz-Rosa D, Diaz-Guerra A, Prados B, Medina JP, Monto F, Ivorra MD, Marquez-Lopez C, Cannavo A, Bernal JA, Koch WJ, Fuster V, de la Pompa JL, Oliver E, Ibanez B (2022) Beta-3 adrenergic receptor overexpression reverses aortic stenosis-induced heart failure and restores balanced mitochondrial dynamics. Basic Res Cardiol 117:62. https://doi.org/10.1007/s00395-022-00966-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riechert E, Kmietczyk V, Stein F, Schwarzl T, Sekaran T, Jurgensen L, Kamuf-Schenk V, Varma E, Hofmann C, Rettel M, Gur K, Olschlager J, Kuhl F, Martin J, Ramirez-Pedraza M, Fernandez M, Doroudgar S, Mendez R, Katus HA, Hentze MW, Volkers M (2021) Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes. Cell Rep 35:109100. https://doi.org/10.1016/j.celrep.2021.109100

Article  CAS  PubMed  Google Scholar 

Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, Bonny A, Brauer M, Brodmann M, Cahill TJ, Carapetis J, Catapano AL, Chugh SS, Cooper LT, Coresh J, Criqui M, DeCleene N, Eagle KA, Emmons-Bell S, Feigin VL, Fernandez-Sola J, Fowkes G, Gakidou E, Grundy SM, He FJ, Howard G, Hu F, Inker L, Karthikeyan G, Kassebaum N, Koroshetz W, Lavie C, Lloyd-Jones D, Lu HS, Mirijello A, Temesgen AM, Mokdad A, Moran AE, Muntner P, Narula J, Neal B, Ntsekhe M, Moraes de Oliveira G, Otto C, Owolabi M, Pratt M, Rajagopalan S, Reitsma M, Ribeiro ALP, Rigotti N, Rodgers A, Sable C, Shakil S, Sliwa-Hahnle K, Stark B, Sundstrom J, Timpel P, Tleyjeh IM, Valgimigli M, Vos T, Whelton PK, Yacoub M, Zuhlke L, Murray C, Fuster V, Group G-N-JGBoCDW (2020) Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD study. J Am Coll Cardiol. 76(2982):3021. https://doi.org/10.1016/j.jacc.2020.11.010