Andreadou I, Cabrera-Fuentes HA, Devaux Y, Frangogiannis NG, Frantz S, Guzik T, Liehn EA, Gomes CPC, Schulz R, Hausenloy DJ (2019) Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities. Cardiovasc Res 115:1117–1130. https://doi.org/10.1093/cvr/cvz050

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL (2005) Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 202:1131–1139. https://doi.org/10.1084/jem.20050914

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bliksoen M, Mariero LH, Torp MK, Baysa A, Ytrehus K, Haugen F, Seljeflot I, Vaage J, Valen G, Stenslokken KO (2016) Extracellular mtDNA activates NF-kappaB via toll-like receptor 9 and induces cell death in cardiomyocytes. Basic Res Cardiol 111:42. https://doi.org/10.1007/s00395-016-0553-6

Article  CAS  PubMed  Google Scholar 

Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

den Haan JM, Kraal G (2012) Innate immune functions of macrophage subpopulations in the spleen. J Innate Immun 4:437–445. https://doi.org/10.1159/000335216

Article  Google Scholar 

Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M (2012) Myocardial infarction accelerates atherosclerosis. Nature 487:325–329. https://doi.org/10.1038/nature11260

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eltzschig HK, Eckle T (2011) Ischemia and reperfusion–from mechanism to translation. Nat Med 17:1391–1401. https://doi.org/10.1038/nm.2507

Article  CAS  PubMed  Google Scholar 

Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A (2015) Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans. JACC Cardiovasc Imaging 8:121–130. https://doi.org/10.1016/j.jcmg.2014.10.009

Article  PubMed  PubMed Central  Google Scholar 

Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC (2018) The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity 48(35–44):e36. https://doi.org/10.1016/j.immuni.2017.11.013

Article  CAS  Google Scholar 

Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J, Alnemri ES (2007) The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14:1590–1604. https://doi.org/10.1038/sj.cdd.4402194

Article  CAS  PubMed  Google Scholar 

Franchi L, Warner N, Viani K, Nunez G (2009) Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 227:106–128. https://doi.org/10.1111/j.1600-065X.2008.00734.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF (2016) The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain Behav Immun 55:215–224. https://doi.org/10.1016/j.bbi.2015.10.009

Article  CAS  PubMed  Google Scholar 

Garcia-Dorado D, Theroux P, Elizaga J, Galinanes M, Solares J, Riesgo M, Gomez MJ, Garcia-Dorado A, Fernandez Aviles F (1987) Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion. Cardiovasc Res 21:537–544. https://doi.org/10.1093/cvr/21.7.537

Article  CAS  PubMed  Google Scholar 

Glogar DH (1986) Definition and significance of the area at risk in myocardial infarct and the ischemic border zone in acute myocardial infarct. Acta Med Austriaca Suppl 36:1–40

CAS  PubMed  Google Scholar 

Guo H, Callaway JB, Ting JP (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21:677–687. https://doi.org/10.1038/nm.3893

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haneklaus M, O’Neill LA (2015) NLRP3 at the interface of metabolism and inflammation. Immunol Rev 265:53–62. https://doi.org/10.1111/imr.12285

Article  CAS  PubMed  Google Scholar 

Heusch G (2023) Cardioprotection and its Translation: A Need for New Paradigms? Or for New Pragmatism? An Opinionated Retro- and Perspective. J Cardiovasc Pharmacol Ther 28:10742484231179612. https://doi.org/10.1177/10742484231179613

Article  PubMed  Google Scholar 

Heusch G (2017) Critical Issues for the Translation of Cardioprotection. Circ Res 120:1477–1486. https://doi.org/10.1161/CIRCRESAHA.117.310820

Article  CAS  PubMed  Google Scholar 

Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773–789. https://doi.org/10.1038/s41569-020-0403-y

Article  PubMed  Google Scholar 

Heusch G (2019) The Spleen in Myocardial Infarction. Circ Res 124:26–28. https://doi.org/10.1161/CIRCRESAHA.118.314331

Article  CAS  PubMed  Google Scholar 

Hiraiwa H, Okumura T, Murohara T (2022) The cardiosplenic axis: the prognostic role of the spleen in heart failure. Heart Fail Rev 27:2005–2015. https://doi.org/10.1007/s10741-022-10248-4

Article  PubMed  PubMed Central  Google Scholar 

Ismahil MA, Hamid T, Bansal SS, Patel B, Kingery JR, Prabhu SD (2014) Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure: critical importance of the cardiosplenic axis. Circ Res 114:266–282. https://doi.org/10.1161/CIRCRESAHA.113.301720

Article  CAS  PubMed  Google Scholar 

Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med 214:3219–3238. https://doi.org/10.1084/jem.20171419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U (2011) Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury. Circulation 123:594–604. https://doi.org/10.1161/CIRCULATIONAHA.110.982777

Article  CAS  PubMed  Google Scholar 

Kono H, Rock KL (2008) How dying cells alert the immune system to danger. Nat Rev Immunol 8:279–289. https://doi.org/10.1038/nri2215

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kubota A, Frangogiannis NG (2022) Macrophages in myocardial infarction. Am J Physiol Cell Physiol 323:C1304–C1324. https://doi.org/10.1152/ajpcell.00230.2022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leemans JC, Cassel SL, Sutterwala FS (2011) Sensing damage by the NLRP3 inflammasome. Immunol Rev 243:152–162. https://doi.org/10.1111/j.1600-065X.2011.01043.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Ni L, Eugenin EA, Heary RF, Elkabes S (2019) Toll-like receptor 9 antagonism modulates astrocyte function and preserves proximal axons following spinal cord injury. Brain Behav Immun 80:328–343. https://doi.org/10.1016/j.bbi.2019.04.010

Article  CAS  PubMed  Google Scholar 

Lieder HR, Kleinbongard P, Skyschally A, Hagelschuer H, Chilian WM, Heusch G (2018) Vago-Splenic Axis in Signal Transduction of Remote Ischemic Preconditioning in Pigs and Rats. Circ Res 123:1152–1163. https://doi.org/10.1161/CIRCRESAHA.118.313859

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu D, Zeng X, Li X, Mehta JL, Wang X (2018) Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases. Basic Res Cardiol 113:5. https://doi.org/10.1007/s00395-017-0663-9

Article  CAS  PubMed  Google Scholar 

Liu J, Cai X, Xie L, Tang Y, Cheng J, Wang J, Wang L, Gong J (2015) Circulating Cell Free Mitochondrial DNA is a Biomarker in the Development of Coronary Heart Disease in the Patients with Type 2 Diabetes. Clin Lab 61:661–667. https://doi.org/10.7754/clin.lab.2014.141132

Article  CAS  PubMed