Abramson, J. S., Mills, E. L., Giebink, G. S., & Quie, P. G. (1982). Depression of monocyte and polymorphonuclear leukocyte oxidative metabolism and bactericidal capacity by influenza A virus. Infection and Immunity, 35, 350–355.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aebi, T., Weisser, M., Bucher, E., Hirsch, H. H., Marsch, S., & Siegemund, M. (2010). Co-infection of influenza B and Streptococci causing severe pneumonia and septic shock in healthy women. BMC Infectious Diseases, 10, 308.

Article  PubMed  PubMed Central  Google Scholar 

Alymova, I. V., Portner, A., Takimoto, T., Boyd, K. L., Babu, Y. S., & McCullers, J. A. (2005). The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy, 49, 398–405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ambigapathy, G., Schmit, T., Mathur, R. K., Nookala, S., Bahri, S., Pirofski, L. A., & Khan, M. N. (2019). Double-edged role of interleukin 17A in Streptococcus pneumoniae pathogenesis during influenza virus coinfection. The Journal of Infectious Diseases, 220, 902–912.

Article  CAS  PubMed  PubMed Central  Google Scholar 

An, C., Wu, Y., Wu, J., Liu, H., Zhou, S., Ge, D., Dong, R., You, L., & Hao, Y. (2022). Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D-mediated pyroptosis. Drug Development Research, 83, 1707–1721.

Article  CAS  PubMed  Google Scholar 

Anand, P. K., Malireddi, R. S., & Kanneganti, T. D. (2011). Role of the Nlrp3 inflammasome in microbial infection. Frontiers in Microbiology, 2, 12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andrewes, C. H., Laidlaw, P. P., & Smith, W. (1935). Influenza: Observations on the recovery of virus from man and on the antibody content of human sera. British Journal of Experimental Pathology, 16, 566–582.

PubMed Central  Google Scholar 

Bao, L., Zhang, C., Dong, J., Zhao, L., Li, Y., & Sun, J. (2020). Oral microbiome and SARS-CoV-2: Beware of lung co-infection. Frontiers in Microbiology, 11, 1840.

Article  PubMed  PubMed Central  Google Scholar 

Barman, T. K., Singh, A. K., Bonin, J. L., Nafiz, T. N., Salmon, S. L., & Metzger, D. W. (2022). Lethal synergy between SARS-CoV-2 and Streptococcus pneumoniae in hACE2 mice and protective efficacy of vaccination. The Journal of Clinical Investigation Insight, 7, e159422.

PubMed  Google Scholar 

Brown, K. M., Sage, V. L., French, A. J., Jones, J. E., Padovani, G. H., Avery, A. J., Myerburg, M. M., Schultz-Cherry, S., Rosch, J. W., Hiller, N. L., & Lakdawala, S. S. (2020). Coinfection of Streptococcus pneumoniae reduces airborne transmission of influenza virus. bioRxiv, 10, 376442.

Google Scholar 

Brown, K. M., Sage, V. L., French, A. J., Jones, J. E., Padovani, G. H., Avery, A. J., Schultz-Cherry, S., Rosch, J. W., Hiller, N. L., & Lakdawala, S. S. (2022). Secondary infection with Streptococcus pneumoniae decreases influenza virus replication and is linked to severe disease. FEMS Microbes, 3, xtac007.

Article  Google Scholar 

Chen, Y. Y., Huang, C. T., Li, S. W., Pan, Y. J., Lin, T. L., & Huang, Y. Y. (2021). Bacterial factors required for Streptococcus pneumoniae coinfection with influenza A virus. Journal of Biomedical Science, 28, 60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo, T., Xiao, J., Li, L., Xu, W., Yuan, Y., Yin, Y., & Zhang, X. (2022). rM2e-ΔPly protein immunization induces protection against influenza viruses and its co-infection with Streptococcus pneumoniae in mice. Molecular Immunology, 152, 86–96.

Article  CAS  PubMed  Google Scholar 

Habibzay, M., Weiss, G., & Hussell, T. (2013). Bacterial superinfection following lung inflammatory disorders. Future Microbiology, 8, 247–256.

Article  CAS  PubMed  Google Scholar 

Han, X., Li, Z., Chen, H., Wang, H., Mei, L., Wu, S., Zhang, T., Liu, B., & Lin, X. (2012). Influenza virus A/Beijing/501/2009 (H1N1) NS1 interacts with β-tubulin and induces disruption of the microtubule network and apoptosis on A549 cells. PLoS ONE, 7, e48340.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hua, T., Wang, H., Fan, X., An, N., Li, J., Song, H., Kong, E., Li, Y., & Yuan, H. (2022). BRD4 inhibition attenuates inflammatory pain by ameliorating NLRP3 inflammasome-induced pyroptosis. Frontiers in Immunology, 13, 837977.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ichinohe, T., Pang, I. K., Kumamoto, Y., Peaper, D. R., Ho, J. H., Murray, T. S., & Iwasaki, A. (2011). Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proceedings of the National Academy of Sciences, 108, 5354–5359.

Article  CAS  Google Scholar 

Jochems, S. P., Marcon, F., Carniel, B. F., Holloway, M., Mitsi, E., Smith, E., Gritzfeld, J. F., Solórzano, C., Reiné, J., Pojar, S., et al. (2018). Inflammation induced by influenza virus impairs human innate immune control of pneumococcus. Nature Immunology, 19, 1299–1308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Julkunen, I., Melén, K., Nyqvist, M., Pirhonen, J., Sareneva, T., & Matikainen, S. (2000). Inflammatory responses in influenza A virus infection. Vaccine, 19, S32–S37.

Article  CAS  PubMed  Google Scholar 

Ketelut-Carneiro, N., & Fitzgerald, K. A. (2022). Apoptosis, pyroptosis, and necroptosis—Oh my! The many ways a cell can die. Journal of Molecular Biology, 434, 167378.

Article  CAS  PubMed  Google Scholar 

LeMessurier, K. S., Iverson, A. R., Chang, T. C., Palipane, M., Vogel, P., Rosch, J. W., & Samarasinghe, A. E. (2019). Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice. Scientific Reports, 9, 19360.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo, T., Zhou, X., Qin, M., Lin, Y., Lin, J., Chen, G., Liu, A., Ouyang, D., Chen, D., & Pan, H. (2022). Corilagin restrains NLRP3 inflammasome activation and pyroptosis through the ROS/TXNIP/NLRP3 pathway to prevent inflammation. Oxidative Medicine and Cellular Longevity, 1155, 1652244.

Google Scholar 

McCullers, J. A. (2006). Insights into the interaction between influenza virus and pneumococcus. Clinical Microbiology Reviews, 19, 571–582.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCullers, J. A., & Rehg, J. E. (2002). Lethal synergism between influenza virus and Streptococcus pneumoniae: Characterization of a mouse model and the role of platelet-activating factor receptor. The Journal of Infectious Diseases, 186, 341–350.

Article  CAS  PubMed  Google Scholar 

McHugh, K. J., Mandalapu, S., Kolls, J. K., Ross, T. M., & Alcorn, J. F. (2013). A novel outbred mouse model of 2009 pandemic influenza and bacterial co-infection severity. PLoS ONE, 8, e82865.

Article  PubMed  PubMed Central  Google Scholar 

Menu, P., & Vince, J. E. (2011). The NLRP3 inflammasome in health and disease: The good, the bad and the ugly. Clinical & Experimental Immunology, 166, 1–15.

Article  CAS  Google Scholar 

Negash, A. A., Ramos, H. J., Crochet, N., Lau, D. T., Doehle, B., Papic, N., Delker, D. A., Jo, J., Bertoletti, A., Hagedorn, C. H., & Gale, M., Jr. (2013). IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathogens, 9, e1003330.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peeters, P. M., Perkins, T. N., Wouters, E. F., Mossman, B. T., & Reynaert, N. L. (2013). Silica induces NLRP3 inflammasome activation in human lung epithelial cells. Particle and Fibre Toxicology, 10, 3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piamsiri, C., Maneechote, C., Jinawong, K., Arunsak, B., Chunchai, T., Nawara, W., Chattipakorn, S. C., & Chattipakorn, N. (2023). GSDMD-mediated pyroptosis dominantly promotes left ventricular remodeling and dysfunction in post-myocardial infarction: A comparison across modes of programmed cell death and mitochondrial involvement. Journal of Translational Medicine, 21, 16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberts, S., Salmon, S. L., Steiner, D. J., Williams, C. M., Metzger, D. W., & Furuya, Y. (2019). Allergic airway disease prevents lethal synergy of influenza A virus—Streptococcus pneumoniae coinfection. Mbio, 10, e01335-e1419.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodriguez-Nava, G., Yanez-Bello, M. A., Trelles-Garcia, D. P., Chung, C. W., Egoryan, G., & Friedman, H. J. (2020). A retrospective study of coinfection of SARS-CoV-2 and Streptococcus pneumoniae in 11 hospitalized patients with severe COVID-19 pneumonia at a single center. Medical Science Monitor, 26, e928754–e928761.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rowe, S. L., Leder, K., Sundaresan, L., Wollersheim, D., Lawrie, J., & Stephens, N. (2023). Excess mortality among people with communicable diseases over a 30-year period, Victoria, Australia: a whole of population cohort study. The Lancet Regional Health–Western Pacific, 100815.

Russier, M., Yang, G., Briard, B., Meliopoulos, V., Cherry, S., & Kanneganti, T. D. (2020). Hemagglutinin stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells. Journal of Virology, 94, e01423-e1519.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmeck, B., Gross, R., N’Guessan, P. D., Hocke, A. C., Hammerschmidt, S., Mitchell, T. J., Rosseau, S., Suttorp, N., & Hippenstiel, S. (2004). Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infection and Immunity, 72, 4940–4947.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmeck, B., Moog, K., Zahlten, J., van Laak, V., N’Guessan, P. D., Opitz, B., Rosseau, S., Suttorp, N., & Hippenstiel, S. (2006). Streptococcus pneumoniae induced c-Jun-N-terminal kinase-and AP-1-dependent IL-8 release by lung epithelial BEAS-2B cells. Respiratory Research, 7, 98.