*Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi, China;

†First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China; and

‡Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Correspondence: Jing Cao, MD, Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China (e-mail: [email protected]) or Ruizan Shi, PhD, Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi 030001, China (e-mail: [email protected]).

Supported by the National College Students Innovation and Entrepreneurship Training Program of China (Grant No. 20210114026), Natural Science Foundation of Shanxi Province (Grant No. 201801D121332), Scholarship Council Foundation of Shanxi Provincial Human Resources and Security Department (Grant No. 20220039), and Scholarship Council Foundation of Shanxi Provincial Education Department (Grant No. 2022-187).

The authors report no conflicts of interest.

Y. Gao designed the experiments and wrote the manuscript. J. Liu, K. Li, and T. Li conducted the experiments. R. Li, W. Zhang, X. Zhang, Y. Wang, M. Chen, R. Shi, and J. Cao collected the data and participated in statistical analyses. All authors have read and approved the final manuscript.