*Department of Pediatrics, Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, China;

†Department of Pediatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China;

‡Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;

§Foshan Fosun Chancheng Hospital, Foshan, China; and

¶Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, China

Correspondence: Riling Chen, MB or Guoda Ma, Ph.D, Shunde Women and Children's Hospital of Guangdong Medical University, No. 1 Baojian Road, Sunde District, Foshan 528300, China (e-mail: [email protected] or (e-mail: [email protected])

Support for this work includes funding from the National Natural Science Foundation of China (81670252 and 81770034), Guangdong Basic and Applied Basic Foundation (2019A1515011306 and 2020A1515010240), Doctor Startup Fund of Shunde Women and Children's Hospital of Guangdong Medical University(2020BSQD003 and 2021BSQD001).

The authors report no conflicts of interest.

Y.Y. Li, C. Tian and S. Huang have full access to all data from the study and take responsibility for the integrity of the data and the accuracy of the data analysis, wrote the first draft of the manuscript. Y.J. Wang, J.P. Qiu, F. Ning, J.H. Guo, and Q.K. Chen were involved in the analysis and interpretation of data. G.D. Ma and R.L. Chen constructed the manuscript and critically revised the manuscript. All authors read and approved the current version of the manuscript.

The data sets used or analyzed during the current study are available from the corresponding author upon reasonable request.

Li, Tian and Huang have contributed equally.