Chen Y, Luo R, Li J, Wang S, Ding J, Zhao K, Lu B, Zhou W (2022) Intrinsic radical species scavenging activities of tea polyphenols nanoparticles block pyroptosis in endotoxin-induced sepsis. ACS Nano 16:2429–2441. https://doi.org/10.1021/acsnano.1c08913

Article  CAS  PubMed  Google Scholar 

Dai S, Ye B, Zhong L, Chen Y, Hong G, Zhao G, Su L, Lu Z (2021) GSDMD mediates LPS-induced septic myocardial dysfunction by regulating ROS-dependent NLRP3 inflammasome activation. Front Cell Develop Biol 9:779432. https://doi.org/10.3389/fcell.2021.779432

Article  Google Scholar 

Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN (2019) Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev 99:1765–1817. https://doi.org/10.1152/physrev.00022.2018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fröhlich GM, Meier P, White SK, Yellon DM, Hausenloy DJ (2013) Myocardial reperfusion injury: looking beyond primary PCI. Eur Heart J 34:1714–1722. https://doi.org/10.1093/eurheartj/eht090

Article  CAS  PubMed  Google Scholar 

Han B, Xu J, Shi X, Zheng Z, Shi F, Jiang F, Han J (2021) DL-3-n-butylphthalide attenuates myocardial hypertrophy by targeting gasdermin D and inhibiting gasdermin D mediated inflammation. Front Pharmacol 12:688140. https://doi.org/10.3389/fphar.2021.688140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han J, Dai S, Zhong L, Shi X, Fan X, Zhong X, Lin W, Su L, Lin S, Han B, Xu J, Hong X, Huang W, Ye B (2022) GSDMD (gasdermin D) mediates pathological cardiac hypertrophy and generates a feed-forward amplification Cascade via mitochondria-STING (stimulator of interferon genes) Axis. Hypertension 79:2505–2518. https://doi.org/10.1161/hypertensionaha.122.20004

Article  CAS  PubMed  Google Scholar 

Han J, Shi X, Xu J, Lin W, Chen Y, Han B, Wang Y, Xu J (2022) DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction. Eur J Pharmaceut Sci 172:106164. https://doi.org/10.1016/j.ejps.2022.106164

Article  CAS  Google Scholar 

Hausenloy DJ, Botker HE, Engstrom T, Erlinge D, Heusch G, Ibanez B, Kloner RA, Ovize M, Yellon DM, Garcia-Dorado D (2017) Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations. Eur Heart J 38:935–941. https://doi.org/10.1093/eurheartj/ehw145

Article  CAS  PubMed  Google Scholar 

Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773–789. https://doi.org/10.1038/s41569-020-0403-y

Article  PubMed  Google Scholar 

Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H (2020) FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol 21:736–745. https://doi.org/10.1038/s41590-020-0669-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang LS, Hong Z, Wu W, Xiong S, Zhong M, Gao X, Rehman J, Malik AB (2020) mtDNA activates cGAS signaling and suppresses the YAP-mediated endothelial cell proliferation program to promote inflammatory injury. Immunity 52(475–486):e475. https://doi.org/10.1016/j.immuni.2020.02.002

Article  CAS  Google Scholar 

Ibáñez B, Heusch G, Ovize M, Van de Werf F (2015) Evolving therapies for myocardial ischemia/reperfusion injury. J Am Coll Cardiol 65:1454–1471. https://doi.org/10.1016/j.jacc.2015.02.032

Article  PubMed  Google Scholar 

Kitchen DB, Decornez H, Furr JR, Bajorath J (2004) Docking and scoring in virtual screening for drug discovery: methods and applications. Nat Rev Drug Discovery 3:935–949. https://doi.org/10.1038/nrd1549

Article  CAS  PubMed  Google Scholar 

Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW, Li J (2017) Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis. Proc Natl Acad Sci USA 114:10642

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lesnefsky EJ, Chen Q, Tandler B, Hoppel CL (2017) Mitochondrial dysfunction and myocardial ischemia-reperfusion: implications for novel therapies. Annu Rev Pharmacol Toxicol 57:535–565. https://doi.org/10.1146/annurev-pharmtox-010715-103335

Article  CAS  PubMed  Google Scholar 

Li Y, Shen J, Fang M, Huang X, Yan H, Jin Y, Li J, Li X (2018) The promising antitumour drug disulfiram inhibits viability and induces apoptosis in cardiomyocytes. Biomed Pharmacother Biomed Pharmacother 108:1062–1069. https://doi.org/10.1016/j.biopha.2018.09.123

Article  CAS  PubMed  Google Scholar 

Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J (2016) Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535:153

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS (2019) Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization. Immunity 51:43-49.e44. https://doi.org/10.1016/j.immuni.2019.04.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J (2009) Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci USA 106:21984–21989. https://doi.org/10.1073/pnas.0910040106

Article  PubMed  PubMed Central  Google Scholar 

Mali VR, Deshpande M, Pan G, Thandavarayan RA, Palaniyandi SS (2016) Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes. Cell Signal 28:1–6. https://doi.org/10.1016/j.cellsig.2015.11.006

Article  CAS  PubMed  Google Scholar 

Nobuhiko K, Stowe IB, Lee BL, Karen OR, Keith A, Søren W, Trinna C, Benjamin H, Merone RG, Phung QT (2015) Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526:666–671

Article  Google Scholar 

Pan G, Deshpande M, Thandavarayan RA (2016) ALDH2 inhibition potentiates high glucose stress-induced injury in cultured cardiomyocytes. J Diabetes Res 2016:1390861

Article  PubMed  PubMed Central  Google Scholar 

Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA (2018) Shiga toxin/lipopolysaccharide activates Caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome. Cell Rep 25:1525-1536.e1527. https://doi.org/10.1016/j.celrep.2018.09.071

Article  CAS  PubMed  Google Scholar 

Rathkey JK, Zhao J, Liu Z, Chen Y (2018) Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Sci Immunol. https://doi.org/10.1126/sciimmunol.aat2738

Article  PubMed  PubMed Central  Google Scholar 

Ren YS, Li HL, Piao XH, Yang ZY, Wang SM, Ge YW (2021) Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: principles and application. Biochem Pharmacol 194:114798. https://doi.org/10.1016/j.bcp.2021.114798

Article  CAS  PubMed  Google Scholar 

Rogers C, Erkes DA, Nardone A, Aplin AE, Fernandes-Alnemri T, Alnemri ES (2019) Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. Nat Commun 10:1689. https://doi.org/10.1038/s41467-019-09397-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruan J, Xia S, Liu X, Lieberman J, Wu H (2018) Cryo-EM structure of the gasdermin A3 membrane pore. Nature 557:62–67. https://doi.org/10.1038/s41586-018-0058-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F (2015) Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526:660–665. https://doi.org/10.1038/nature15514

Article  CAS  PubMed  Google Scholar 

Shi J, Gao W, Shao F (2017) Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci 42:245–254. https://doi.org/10.1016/j.tibs.2016.10.004

Article  CAS  PubMed  Google Scholar 

Shi H, Gao Y, Dong Z, Yang J, Gao R, Li X, Zhang S, Ma L, Sun X, Wang Z, Zhang F, Hu K, Sun A, Ge J (2021) GSDMD-mediated cardiomyocyte pyroptosis promotes myocardial I/R injury. Circ Res 129:383–396. https://doi.org/10.1161/circresaha.120.318629

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Zhang B, Chu Z, Jiang F, Han J (2021) Wogonin alleviates cisplatin-induced cardiotoxicity in mice via inhibiting gasdermin D-mediated pyroptosis. J Cardiovasc Pharmacol 78:597–603. https://doi.org/10.1097/fjc.0000000000001085

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad