Ahmad T, Miller PE, McCullough M, Desai NR, Riello R, Psotka M, Bohm M, Allen LA, Teerlink JR, Rosano GMC, Lindenfeld J (2019) Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials. Eur J Heart Fail 21:1064–1078. https://doi.org/10.1002/ejhf.1557
Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Kruger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP (2016) The failing heart relies on ketone bodies as a fuel. Circulation 133:698–705. https://doi.org/10.1161/CIRCULATIONAHA.115.017355
Article CAS PubMed PubMed Central Google Scholar
Batlle DC, Peces R, LaPointe MS, Ye M, Daugirdas JT (1993) Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle. Am J Physiol 264:C932-943. https://doi.org/10.1152/ajpcell.1993.264.4.C932
Article CAS PubMed Google Scholar
Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE (2016) Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation 133:706–716. https://doi.org/10.1161/CIRCULATIONAHA.115.017545
Article CAS PubMed PubMed Central Google Scholar
Bing RJ, Siegel A, Ungar I, Gilbert M (1954) Metabolism of the human heart. Am J Med 16:504–515. https://doi.org/10.1016/0002-9343(54)90365-4
Article CAS PubMed Google Scholar
Boedtkjer E (2018) Acid-base regulation and sensing: Accelerators and brakes in metabolic regulation of cerebrovascular tone. J Cereb Blood Flow Metab 38:588–602. https://doi.org/10.1177/0271678X17733868
Article CAS PubMed Google Scholar
Boedtkjer E, Damkier HH, Aalkjaer C (2012) NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pHi in the vascular wall. J Physiol 590:1895–1906. https://doi.org/10.1113/jphysiol.2011.227132
Article CAS PubMed PubMed Central Google Scholar
Boedtkjer E, Hansen KB, Boedtkjer DMB, Aalkjaer C, Boron WF (2016) Extracellular HCO3– is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ. J Cereb Blood Flow Metab 36:965–980. https://doi.org/10.1177/0271678X15610787
Article CAS PubMed Google Scholar
Boedtkjer E, Matchkov VV, Boedtkjer DM, Aalkjaer C (2016) Negative News: Cl– and HCO3– in the vascular wall. Physiology (Bethesda) 31:370–383. https://doi.org/10.1152/physiol.00001.2016
Article CAS PubMed Google Scholar
Boedtkjer E, Praetorius J, Matchkov VV, Stankevicius E, Mogensen S, Fuchtbauer AC, Simonsen U, Fuchtbauer EM, Aalkjaer C (2011) Disruption of Na+, HCO3– cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca2+ sensitivity, and hypertension development in mice. Circulation 124:1819–1829. https://doi.org/10.1161/CIRCULATIONAHA.110.015974
Article CAS PubMed Google Scholar
Boedtkjer E, Praetorius J, Aalkjaer C (2006) NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells. Circ Res 98:515–523. https://doi.org/10.1161/01.RES.0000204750.04971.76
Article CAS PubMed Google Scholar
Boedtkjer E, Aalkjaer C (2012) Intracellular pH in the resistance vasculature: regulation and functional implications. J Vasc Res 49:479–496. https://doi.org/10.1159/000341235
Article CAS PubMed Google Scholar
Boedtkjer E, Aalkjaer C (2022) The solution to bicarbonate. Am J Physiol Heart Circ Physiol 322:H685–H686. https://doi.org/10.1152/ajpheart.00057.2022
Article CAS PubMed PubMed Central Google Scholar
Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8
Article CAS PubMed PubMed Central Google Scholar
Botker HE, Lassen TR, Jespersen NR (2018) Clinical translation of myocardial conditioning. Am J Physiol Heart Circ Physiol 314:H1225–H1252. https://doi.org/10.1152/ajpheart.00027.2018
Article CAS PubMed Google Scholar
Cahill GF Jr (2006) Fuel metabolism in starvation. Annu Rev Nutr 26:1–22. https://doi.org/10.1146/annurev.nutr.26.061505.111258
Article CAS PubMed Google Scholar
Cahill GF Jr, Herrera MG, Morgan AP, Soeldner JS, Steinke J, Levy PL, Reichard GA Jr, Kipnis DM (1966) Hormone-fuel interrelationships during fasting. J Clin Invest 45:1751–1769. https://doi.org/10.1172/JCI105481
Article CAS PubMed PubMed Central Google Scholar
Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP, Allison M, Hemingway H, Cleland JG, McMurray JJV, Rahimi K (2018) Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet 391:572–580. https://doi.org/10.1016/S0140-6736(17)32520-5
Article PubMed PubMed Central Google Scholar
Cox PJ, Kirk T, Ashmore T, Willerton K, Evans R, Smith A, Murray AJ, Stubbs B, West J, McLure SW, King MT, Dodd MS, Holloway C, Neubauer S, Drawer S, Veech RL, Griffin JL, Clarke K (2016) Nutritional ketosis alters fuel preference and thereby endurance performance in athletes. Cell Metab 24:256–268. https://doi.org/10.1016/j.cmet.2016.07.010
Article CAS PubMed Google Scholar
Ferrannini E, Baldi S, Frascerra S, Astiarraga B, Heise T, Bizzotto R, Mari A, Pieber TR, Muscelli E (2016) Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes. Diabetes 65:1190–1195. https://doi.org/10.2337/db15-1356
Article CAS PubMed Google Scholar
Gaskell WH (1880) On the Tonicity of the Heart and Blood Vessels. J Physiol 3:48–92. https://doi.org/10.1113/jphysiol.1880.sp000083
Article CAS PubMed PubMed Central Google Scholar
Gopalasingam N, Christensen KH, Berg Hansen K, Nielsen R, Johannsen M, Gormsen LC, Boedtkjer E, Norregaard R, Moller N, Wiggers H (2023) Stimulation of the hydroxycarboxylic acid receptor 2 with the ketone body 3-hydroxybutyrate and niacin in patients with chronic heart failure: Hemodynamic and metabolic effects. J Am Heart Assoc 12:e029849. https://doi.org/10.1161/JAHA.123.029849
Article PubMed PubMed Central Google Scholar
Gormsen LC, Svart M, Thomsen HH, Sondergaard E, Vendelbo MH, Christensen N, Tolbod LP, Harms HJ, Nielsen R, Wiggers H, Jessen N, Hansen J, Botker HE, Moller N (2017) Ketone body infusion with 3-hydroxybutyrate reduces myocardial glucose uptake and increases blood flow in humans: A positron emission tomography study. J Am Heart Assoc 6:e005066. https://doi.org/10.1161/JAHA.116.005066
Article PubMed PubMed Central Google Scholar
Halestrap AP, Meredith D (2004) The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447:619–628. https://doi.org/10.1007/s00424-003-1067-2
Article CAS PubMed Google Scholar
Halestrap AP, Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343(Pt 2):281–299
Article CAS PubMed PubMed Central Google Scholar
Hansen KB, Staehr C, Rohde PD, Homilius C, Kim S, Nyegaard M, Matchkov VV, Boedtkjer E (2020) PTPRG is an ischemia risk locus essential for HCO3–-dependent regulation of endothelial function and tissue perfusion. Elife 9:e57553. https://doi.org/10.7554/eLife.57553
Article CAS PubMed PubMed Central Google Scholar
Heggermont WA, Papageorgiou AP, Heymans S, van Bilsen M (2016) Metabolic support for the heart: complementary therapy for heart failure? Eur J Heart Fail 18:1420–1429. https://doi.org/10.1002/ejhf.678
Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP (2019) The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. JCI Insight 4:e124079. https://doi.org/10.1172/jci.insight.124079
Article PubMed PubMed Central Google Scholar
Husted AS, Trauelsen M, Rudenko O, Hjorth SA, Schwartz TW (2017) GPCR-mediated signaling of metabolites. Cell Metab 25:777–796. https://doi.org/10.1016/j.cmet.2017.03.008
Article CAS PubMed Google Scholar
Jacobus WE, Pores IH, Lucas SK, Weisfeldt ML, Flaherty JT (1982) Intracellular acidosis and contractility in the normal and ischemic heart as examined by 31P NMR. J Mol Cell Cardiol 14(3):13–20. https://doi.org/10.1016/0022-2828(82)90124-9
留言 (0)