Acharya A, Baek ST, Huang G, Eskiocak B, Goetsch S, Sung CY, Banfi S, Sauer MF, Olsen GS, Duffield JS, Olson EN, Tallquist MD (2012) The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development 139:2139–2149. https://doi.org/10.1242/dev.079970

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad F, Lal H, Zhou J, Vagnozzi RJ, Yu JE, Shang X, Woodgett JR, Gao E, Force T (2014) Cardiomyocyte-specific deletion of Gsk3alpha mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. J Am Coll Cardiol 64:696–706. https://doi.org/10.1016/j.jacc.2014.04.068

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad F, Singh AP, Tomar D, Rahmani M, Zhang Q, Woodgett JR, Tilley DG, Lal H, Force T (2019) Cardiomyocyte-GSK-3alpha promotes mPTP opening and heart failure in mice with chronic pressure overload. J Mol Cell Cardiol 130:65–75. https://doi.org/10.1016/j.yjmcc.2019.03.020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad F, Woodgett JR (2020) Emerging roles of GSK-3alpha in pathophysiology: emphasis on cardio-metabolic disorders. Biochim Biophys Acta Mol Cell Res 1867:118616. https://doi.org/10.1016/j.bbamcr.2019.118616

Article  CAS  PubMed  Google Scholar 

Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2:737–744. https://doi.org/10.1038/35036374

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brauninger H, Kruger S, Bacmeister L, Nystrom A, Eyerich K, Westermann D, Lindner D (2023) Matrix metalloproteinases in coronary artery disease and myocardial infarction. Basic Res Cardiol 118:18. https://doi.org/10.1007/s00395-023-00987-2

Article  PubMed  PubMed Central  Google Scholar 

Brooks HL, Lindsey ML (2018) Guidelines for authors and reviewers on antibody use in physiology studies. Am J Physiol Heart Circ Physiol 314:H724–H732. https://doi.org/10.1152/ajpheart.00512.2017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chalise U, Becirovic-Agic M, Lindsey ML (2023) The cardiac wound healing response to myocardial infarction. WIREs Mech Dis 15:e1584. https://doi.org/10.1002/wsbm.1584

Article  CAS  PubMed  Google Scholar 

Cinetto F, Ceccato J, Caputo I, Cangiano D, Montini B, Lunardi F, Piazza M, Agostini C, Calabrese F, Semenzato G, Rattazzi M, Gurrieri C, Scarpa R, Felice C, Vianello F (2021) GSK-3 inhibition modulates metalloproteases in a model of lung inflammation and fibrosis. Front Mol Biosci 8:633054. https://doi.org/10.3389/fmolb.2021.633054

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cortes-Vieyra R, Silva-Garcia O, Gomez-Garcia A, Gutierrez-Castellanos S, Alvarez-Aguilar C, Baizabal-Aguirre VM (2021) Glycogen synthase kinase 3beta modulates the inflammatory response activated by bacteria, viruses, and parasites. Front Immunol 12:675751. https://doi.org/10.3389/fimmu.2021.675751

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR (2007) Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell 12:957–971. https://doi.org/10.1016/j.devcel.2007.04.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frangogiannis NG (2006) The mechanistic basis of infarct healing. Antioxid Redox Signal 8:1907–1939. https://doi.org/10.1089/ars.2006.8.1907

Article  CAS  PubMed  Google Scholar 

Frangogiannis NG (2015) Pathophysiology of myocardial infarction. Compr Physiol 5:1841–1875. https://doi.org/10.1002/cphy.c150006

Article  PubMed  Google Scholar 

Fu X, Khalil H, Kanisicak O, Boyer JG, Vagnozzi RJ, Maliken BD, Sargent MA, Prasad V, Valiente-Alandi I, Blaxall BC, Molkentin JD (2018) Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. J Clin Investig 128:2127–2143. https://doi.org/10.1172/JCI98215

Article  PubMed  PubMed Central  Google Scholar 

Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ (2010) A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res 107:1445–1453. https://doi.org/10.1161/CIRCRESAHA.110.223925

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh S, Hayden MS (2008) New regulators of NF-kappaB in inflammation. Nat Rev Immunol 8:837–848. https://doi.org/10.1038/nri2423

Article  CAS  PubMed  Google Scholar 

Hess A, Borchert T, Ross TL, Bengel FM, Thackeray JT (2022) Characterizing the transition from immune response to tissue repair after myocardial infarction by multiparametric imaging. Basic Res Cardiol 117:14. https://doi.org/10.1007/s00395-022-00922-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hesse J, Owenier C, Lautwein T, Zalfen R, Weber JF, Ding Z, Alter C, Lang A, Grandoch M, Gerdes N, Fischer JW, Klau GW, Dieterich C, Kohrer K, Schrader J (2021) Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart. Elife. https://doi.org/10.7554/eLife.65921

Article  PubMed  PubMed Central  Google Scholar 

Hoffmeister L, Diekmann M, Brand K, Huber R (2020) GSK3: a kinase balancing promotion and resolution of inflammation. Cells. https://doi.org/10.3390/cells9040820

Article  PubMed  PubMed Central  Google Scholar 

Humeres C, Frangogiannis NG (2019) Fibroblasts in the infarcted, remodeling, and failing heart. JACC Basic Transl Sci 4:449–467. https://doi.org/10.1016/j.jacbts.2019.02.006

Article  PubMed  PubMed Central  Google Scholar 

Isogai C, Laug WE, Shimada H, Declerck PJ, Stins MF, Durden DL, Erdreich-Epstein A, DeClerck YA (2001) Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin. Cancer Res 61:5587–5594

CAS  PubMed  Google Scholar 

Jope RS, Cheng Y, Lowell JA, Worthen RJ, Sitbon YH, Beurel E (2017) Stressed and inflamed, can GSK3 be blamed? Trends Biochem Sci 42:180–192. https://doi.org/10.1016/j.tibs.2016.10.009

Article  CAS  PubMed  Google Scholar 

Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, Lin S-CJ, Aronow BJ, Tallquist MD, Molkentin JD (2016) Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun 7:12260. https://doi.org/10.1038/ncomms12260

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim HS, Skurk C, Thomas SR, Bialik A, Suhara T, Kureishi Y, Birnbaum M, Keaney JF Jr, Walsh K (2002) Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem 277:41888–41896. https://doi.org/10.1074/jbc.M206657200

Article  CAS  PubMed  Google Scholar 

Lal H, Ahmad F, Woodgett J, Force T (2015) The GSK-3 family as therapeutic target for myocardial diseases. Circ Res 116:138–149. https://doi.org/10.1161/CIRCRESAHA.116.303613

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lal H, Ahmad F, Zhou J, Yu JE, Vagnozzi RJ, Guo Y, Yu D, Tsai EJ, Woodgett J, Gao E, Force T (2014) Cardiac fibroblast glycogen synthase kinase-3beta regulates ventricular remodeling and dysfunction in ischemic heart. Circulation 130:419–430. https://doi.org/10.1161/CIRCULATIONAHA.113.008364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lal H, Zhou J, Ahmad F, Zaka R, Vagnozzi RJ, Decaul M, Woodgett J, Gao E, Force T (2012) Glycogen synthase kinase-3alpha limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death. Circulation 125:65–75. https://doi.org/10.1161/CIRCULATIONAHA.111.050666

Article  CAS  PubMed  Google Scholar 

Lee NV, Sato M, Annis DS, Loo JA, Wu L, Mosher DF, Iruela-Arispe ML (2006) ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2. EMBO J 25:5270–5283. https://doi.org/10.1038/sj.emboj.7601400

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lendahl U, Muhl L, Betsholtz C (2022) Identification, discrimination and heterogeneity of fibroblasts. Nat Commun 13:3409. https://doi.org/10.1038/s41467-022-30633-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Zhu H, Liu C, Wang Y, Wang D, Liu H, Cao W, Hu Y, Lin Q, Tong C, Lu M, Sachinidis A, Li L, Peng L (2019) GSK-3beta inhibition protects the rat heart from the lipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity. J Cell Mol Med 23:7796–7809. https://doi.org/10.1111/jcmm.14656

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lindsey ML