Adamo L, Rocha-Resende C, Prabhu SD, Mann DL (2020) Reappraising the role of inflammation in heart failure. Nat Rev Cardiol 17:269–285. https://doi.org/10.1038/s41569-019-0315-x

Article  PubMed  Google Scholar 

Ali M, Pulli B, Courties G, Tricot B, Sebas M, Iwamoto Y, Hilgendorf I, Schob S, Dong A, Zheng W, Skoura A, Kalgukar A, Cortes C, Ruggeri R, Swirski FK, Nahrendorf M, Buckbinder L, Chen JW (2016) Myeloperoxidase inhibition improves ventricular function and remodeling after experimental myocardial infarction. JACC Basic Transl Sci 1:633–643. https://doi.org/10.1016/J.JACBTS.2016.09.004

Article  PubMed  PubMed Central  Google Scholar 

Barnabei MS, Palpant NJ, Metzger JM (2010) Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains. Phys Genomics 42A:103–113. https://doi.org/10.1152/physiolgenomics.00071.2010

Article  CAS  Google Scholar 

Brennan ML, Anderson MM, Shih DM, Qu XD, Wang X, Mehta AC, Lim LL, Shi W, Hazen SL, Jacob JS, Crowley JR, Heinecke JW, Lusis AJ (2001) Increased atherosclerosis in myeloperoxidase-deficient mice. J Clin Invest 107:419–430. https://doi.org/10.1172/JCI8797

Article  CAS  PubMed  PubMed Central  Google Scholar 

Butturini E, de Prati AC, Mariotto S (2020) Redox regulation of STAT1 and STAT3 signaling. Int J Mol Sci 21:7034. https://doi.org/10.3390/IJMS21197034

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canton M, Menazza S, Sheeran FL, Polverino De Laureto P, Di Lisa F, Pepe S (2011) Oxidation of myofibrillar proteins in human heart failure. J Am Coll Cardiol 57:300–309. https://doi.org/10.1016/J.JACC.2010.06.058

Article  CAS  PubMed  Google Scholar 

Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, Civelli M, Lamantia G, Colombo N, Curigliano G, Fiorentini C, Cipolla CM (2015) Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation 131:1981–1988. https://doi.org/10.1161/CIRCULATIONAHA.114.013777

Article  CAS  PubMed  Google Scholar 

Cardinale D, Iacopo F, Cipolla CM (2020) Cardiotoxicity of anthracyclines. Front Cardiovasc Med 7:26. https://doi.org/10.3389/FCVM.2020.00026/BIBTEX

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carr JS, King S, Dekaney CM (2017) Depletion of enteric bacteria diminishes leukocyte infiltration following doxorubicin-induced small intestinal damage in mice. PLoS ONE 12:e0173429. https://doi.org/10.1371/JOURNAL.PONE.0173429

Article  PubMed  PubMed Central  Google Scholar 

Chen B, Daneshgar N, Lee HC, Song LS, Dai DF (2023) Mitochondrial oxidative stress mediates bradyarrhythmia in leigh syndrome mitochondrial disease mice. Antioxidants 12:1001. https://doi.org/10.3390/ANTIOX12051001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christidi E, Brunham LR (2021) Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death Dis 12:1–15. https://doi.org/10.1038/s41419-021-03614-x

Article  CAS  Google Scholar 

Cray P, Sheahan BJ, Cortes JE, Dekaney CM (2020) Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers. Sci Rep 10:1–12. https://doi.org/10.1038/s41598-020-78473-1

Article  CAS  Google Scholar 

Cuenda A, Rousseau S (2007) p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta Mol Cell Res 1773:1358–1375. https://doi.org/10.1016/J.BBAMCR.2007.03.010

Article  CAS  Google Scholar 

Delrue L, Vanderheyden M, Beles M, Paolisso P, Di Gioia G, Dierckx R, Verstreken S, Goethals M, Heggermont W, Bartunek J (2021) Circulating SERPINA3 improves prognostic stratification in patients with a de novo or worsened heart failure. ESC Hear Fail 8:4780–4790. https://doi.org/10.1002/EHF2.13659

Article  Google Scholar 

Di Marco A, Gaetani M, Orezzi P, Scarpinato BM, Silvestrini R, Soldati M, Dasdia T, Valentini L (1964) ‘Daunomycin’, a new antibiotic of the rhodomycin group. Nature 201:706–707. https://doi.org/10.1038/201706a0

Article  Google Scholar 

Dorn LE, Petrosino JM, Wright P, Accornero F (2018) CTGF/CCN2 is an autocrine regulator of cardiac fibrosis. J Mol Cell Cardiol 121:205–211. https://doi.org/10.1016/j.yjmcc.2018.07.130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dutta S, Sengupta P (2016) Men and mice: relating their ages. Life Sci 152:244–248. https://doi.org/10.1016/J.LFS.2015.10.025

Article  CAS  PubMed  Google Scholar 

Farhad H, Staziaki PV, Addison D, Coelho-Filho OR, Shah RV, Mitchell RN, Szilveszter B, Abbasi SA, Kwong RY, Scherrer-Crosbie M, Hoffmann U, Jerosch-Herold M, Neilan TG (2016) Characterization of the changes in cardiac structure and function in mice treated with anthracyclines using serial cardiac magnetic resonance imaging. Circ Cardiovasc Imaging 9:e003584. https://doi.org/10.1161/CIRCIMAGING.115.003584

Article  PubMed  PubMed Central  Google Scholar 

Fornaro A, Olivotto I, Rigacci L, Ciaccheri M, Tomberli B, Ferrantini C, Coppini R, Girolami F, Mazzarotto F, Chiostri M, Milli M, Marchionni N, Castelli G (2018) Comparison of long-term outcome in anthracycline-related versus idiopathic dilated cardiomyopathy: a single centre experience. Eur J Heart Fail 20:898–906. https://doi.org/10.1002/ejhf.1049

Article  CAS  PubMed  Google Scholar 

Hoggatt J, Hoggatt AF, Tate TA, Fortman J, Pelus LM (2016) Bleeding the laboratory mouse: not all methods are equal. Exp Hematol 44:132-137.e1. https://doi.org/10.1016/J.EXPHEM.2015.10.008

Article  PubMed  Google Scholar 

Hullin R, Métrich M, Sarre A, Basquin D, Maillard M, Regamey J, Martin D (2018) Diverging effects of enalapril or eplerenone in primary prevention against doxorubicin-induced cardiotoxicity. Cardiovasc Res 114:272–281. https://doi.org/10.1093/CVR/CVX162

Article  CAS  PubMed  Google Scholar 

Ibáñez B (2023) A tale of pigs, beta-blockers and genetic variants. Basic Res Cardiol 118:1–4. https://doi.org/10.1007/s00395-023-00998-z

Article  Google Scholar 

Kalász J, Pásztor ET, Fagyas M, Balogh Á, Tóth A, Csató V, Édes I, Papp Z, Borbély A (2015) Myeloperoxidase impairs the contractile function in isolated human cardiomyocytes. Free Radic Biol Med 84:116–127. https://doi.org/10.1016/J.FREERADBIOMED.2015.02.036

Article  PubMed  Google Scholar 

Kargapolova Y, Geißen S, Zheng R, Baldus S, Winkels H, Adam M (2021) The enzymatic and non-enzymatic function of myeloperoxidase (MPO) in inflammatory communication. Antioxidants 10:562. https://doi.org/10.3390/ANTIOX10040562

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kleinbongard P, Lieder HR, Skyschally A, Alloosh M, Gödecke A, Rahmann S, Sturek M, Heusch G (2022) Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome. Basic Res Cardiol 117:1–24. https://doi.org/10.1007/S00395-022-00965-0

Article  Google Scholar 

Kleinbongard P, Lieder HR, Skyschally A, Heusch G (2023) No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs. Basic Res Cardiol 118:1–16. https://doi.org/10.1007/s00395-023-00993-4

Article  CAS  Google Scholar 

Klinke A, Nussbaum C, Kubala L, Friedrichs K, Rudolph TK, Rudolph V, Paust HJ, Schröder C, Benten D, Lau D, Szocs K, Furtmüller PG, Heeringa P, Sydow K, Duchstein HJ, Ehmke H, Schumacher U, Meinertz T, Sperandio M, Baldus S (2011) Myeloperoxidase attracts neutrophils by physical forces. Blood 117:1350–1358. https://doi.org/10.1182/BLOOD-2010-05-284513

Article  CAS  PubMed  Google Scholar 

Kwok JC, Richardson DR (2000) The cardioprotective effect of the iron chelator dexrazoxane (ICRF-187) on anthracycline-mediated cardiotoxicity. Redox Rep 5:317–324. https://doi.org/10.1179/135100000101535898

Article  CAS  PubMed  Google Scholar 

Ky B, Putt M, Sawaya H, French B, Januzzi JL, Sebag IA, Plana JC, Cohen V, Banchs J, Carver JR, Wiegers SE, Martin RP, Picard MH, Gerszten RE, Halpern EF, Passeri J, Kuter I, Scherrer-Crosbie M (2014) Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab. J Am Coll Cardiol 63:809–816. https://doi.org/10.1016/j.jacc.2013.10.061

Article  CAS  PubMed  Google Scholar 

Lam MPY, Ping P, Murphy E (2016) Proteomics research in cardiovascular medicine and biomarker discovery. J Am Coll Cardiol 68:2819–2830. https://doi.org/10.1016/J.JACC.2016.10.031

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li DL, Wang ZV, Ding G, Tan W, Luo X, Criollo A, Xie M, Jiang N, May H, Kyrychenko V, Schneider JW, Gillette TG, Hill JA (2016) Doxorubicin blocks cardiomyocyte autophagic flux by inhibiting lysosome acidification. Circulation 133:1668–1687. https://doi.org/10.1161/CIRCULATIONAHA.115.017443/-/DC1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lipshultz SE, Rifai N, Dalton VM, Levy DE, Silverman LB, Lipsitz SR, Colan SD, Asselin BL, Barr RD, Clavell LA, Hurwitz CA, Moghrabi A, Samson Y, Schorin MA, Gelber RD, Sallan SE (2004) The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med 351:145–153. https://doi.org/10.1056/NEJMOA035153

Article  CAS  PubMed  Google Scholar