Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53

Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A (2018) How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 25(1):104–113. https://doi.org/10.1038/cdd.2017.169

Article  CAS  PubMed  Google Scholar 

Avery-Kiejda KA, Morten B, Wong-Brown MW, Mathe A, Scott RJ (2014) The relative mRNA expression of p53 isoforms in breast cancer is associated with clinical features and outcome. Carcinogenesis 35(3):586–596. https://doi.org/10.1093/carcin/bgt411

Article  CAS  PubMed  Google Scholar 

Baslan T, Morris JPt, Zhao Z, Reyes J, Ho YJ, Tsanov KM, Bermeo J, Tian S, Zhang S, Askan G, Yavas A, Lecomte N, Erakky A, Varghese AM, Zhang A, Kendall J, Ghiban E, Chorbadjiev L, Wu J, ... Lowe SW (2022) Ordered and deterministic cancer genome evolution after p53 loss. Nature 608(7924):795-802. https://doi.org/10.1038/s41586-022-05082-5

Bejarano I, Espino J, Marchena AM, Barriga C, Paredes SD, Rodriguez AB, Pariente JA (2011) Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem 353(1–2):167–176. https://doi.org/10.1007/s11010-011-0783-8

Article  CAS  PubMed  Google Scholar 

Ben-David U, Amon A (2020) Context is everything: aneuploidy in cancer. Nat Rev Genet 21(1):44–62. https://doi.org/10.1038/s41576-019-0171-x

Article  CAS  PubMed  Google Scholar 

Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, ... Meyerson M (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463(7283):899–905. https://doi.org/10.1038/nature08822

Bolton H, Graham SJL, Van der Aa N, Kumar P, Theunis K, Fernandez Gallardo E, Voet T, Zernicka-Goetz M (2016) Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nat Commun 7:11165. https://doi.org/10.1038/ncomms11165

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourdon JC, Khoury MP, Diot A, Baker L, Fernandes K, Aoubala M, Quinlan P, Purdie CA, Jordan LB, Prats AC, Lane DP, Thompson AM (2011) p53 mutant breast cancer patients expressing p53gamma have as good a prognosis as wild-type p53 breast cancer patients. Breast Cancer Res 13(1):R7. https://doi.org/10.1186/bcr2811

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buscemi G, Ricci C, Zannini L, Fontanella E, Plevani P, Delia D (2014) Bimodal regulation of p21(waf1) protein as function of DNA damage levels. Cell Cycle 13(18):2901–2912. https://doi.org/10.4161/15384101.2014.946852

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303(5660):1010–1014. https://doi.org/10.1126/science.1092734

Article  CAS  PubMed  Google Scholar 

Cimini D, Howell B, Maddox P, Khodjakov A, Degrassi F, Salmon ED (2001) Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol 153(3):517–527. https://doi.org/10.1083/jcb.153.3.517

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ (2013) Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell 155(4):948–962. https://doi.org/10.1016/j.cell.2013.10.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dudka D, Noatynska A, Smith CA, Liaudet N, McAinsh AD, Meraldi P (2018) Complete microtubule-kinetochore occupancy favours the segregation of merotelic attachments. Nat Commun 9(1):2042. https://doi.org/10.1038/s41467-018-04427-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duijf PH, Schultz N, Benezra R (2013) Cancer cells preferentially lose small chromosomes. Int J Cancer 132(10):2316–2326. https://doi.org/10.1002/ijc.27924

Article  CAS  PubMed  Google Scholar 

Emon B, Bauer J, Jain Y, Jung B, Saif T (2018) Biophysics of tumor microenvironment and cancer metastasis - a mini review. Comput Struct Biotechnol J 16:279–287. https://doi.org/10.1016/j.csbj.2018.07.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Engeland K (2022) Cell cycle regulation: p53–p21-RB signaling. Cell Death Differ 29(5):946–960. https://doi.org/10.1038/s41418-022-00988-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu X, Wu S, Li B, Xu Y, Liu J (2020) Functions of p53 in pluripotent stem cells. Protein Cell 11(1):71–78. https://doi.org/10.1007/s13238-019-00665-x

Article  CAS  PubMed  Google Scholar 

Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, ... Hahn WC (2018) Mutational processes shape the landscape of TP53 mutations in human cancer. Nat Genet 50(10):1381–1387. https://doi.org/10.1038/s41588-018-0204-y

Goldman MJ, Craft B, Hastie M, Repecka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, Zhu J, Haussler D (2020) Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol 38(6):675–678. https://doi.org/10.1038/s41587-020-0546-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonzales F, Cheok MH (2018) Impact of CNA on AML prognosis. Oncotarget 9(16):12540–12541. https://doi.org/10.18632/oncotarget.23404

Article  PubMed  Google Scholar 

Hinchcliffe EH, Day CA, Karanjeet KB, Fadness S, Langfald A, Vaughan KT, Dong Z (2016) Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation. Nat Cell Biol 18(6):668–675. https://doi.org/10.1038/ncb3348

Article  CAS  PubMed  Google Scholar 

Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE (2017) Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation. Mol Biol Cell 28(14):2010–2022. https://doi.org/10.1091/mbc.E17-01-0010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joruiz SM, Bourdon JC (2016) p53 isoforms: key regulators of the cell fate decision. Cold Spring Harb Perspect Med 6(8). https://doi.org/10.1101/cshperspect.a026039

Kaiser M, Kuhnl A, Reins J, Fischer S, Ortiz-Tanchez J, Schlee C, Mochmann LH, Heesch S, Benlasfer O, Hofmann WK, Thiel E, Baldus CD (2011) Antileukemic activity of the HSP70 inhibitor pifithrin-mu in acute leukemia. Blood Cancer J 1(7):e28. https://doi.org/10.1038/bcj.2011.28

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Miller C, Shen Y, Karimi M, Chen H, Kim P, ... Wang C (2018) Genomic and molecular landscape of DNA damage repair deficiency across The Cancer Genome Atlas. Cell Rep 23(1):239–254 e236. https://doi.org/10.1016/j.celrep.2018.03.076

Lane DP, Cheok CF, Lain S (2010) p53-based cancer therapy. Cold Spring Harb Perspect Biol 2(9):a001222. https://doi.org/10.1101/cshperspect.a001222

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SJ, Ahn H, Nam KW, Kim KH, Mar W (2012) Effects of rutaecarpine on hydrogen peroxide-induced apoptosis in murine hepa-1c1c7 cells. Biomol Ther (seoul) 20(5):487–491. https://doi.org/10.4062/biomolther.2012.20.5.487

Article  CAS  PubMed  Google Scholar 

Leu JI, Dumont P, Hafey M, Murphy ME, George DL (2004) Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6(5):443–450. https://doi.org/10.1038/ncb1123

Article  CAS  PubMed  Google Scholar 

Li F, Wang J, Liu A, Xin L, Zhong S, Hong Y, Chen Y (2019) Prolonged lumbosacral pain as the initial presentation in acute lymphoblastic leukemia in an adult: a case report. Medicine (Baltimore) 98(24):e15912. https://doi.org/10.1097/MD.0000000000015912

Article  PubMed  Google Scholar 

Li Z, Zhao J, Li Q, Yang W, Song Q, Li W, Liu J (2010) KLF4 promotes hydrogen-peroxide-induced apoptosis of chronic myeloid leukemia cells involving the bcl-2/bax pathway. Cell Stress Chaperones 15(6):905–912. https://doi.org/10.1007/s12192-010-0199-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Winey M (2012) The MPS1 family of protein kinases. Annu Rev Biochem 81:561–585. https://doi.org/10.1146/annurev-biochem-061611-090435

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lukow DA, Sausville EL, Suri P, Chunduri NK, Wieland A, Leu J, Smith JC, Girish V, Kumar AA, Kendall J, Wang Z, Storchova Z, Sheltzer JM (2021) Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies. Dev Cell 56(17):2427-2439 e2424. https://doi.org/10.1016/j.devcel.2021.07.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lundberg A, Yi JJJ, Lindstrom LS, Tobin NP (2022) Reclassifying tumour cell cycle activity in terms of its tissue of origin. NPJ Precis Oncol 6(1):59. https://doi.org/10.1038/s41698-022-00302-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mierke CT, Sauer F, Grosser S, Puder S, Fischer T, Kas JA (2018) The two faces of enhanced stroma: stroma acts as a tumor promoter and a steric obstacle. NMR Biomed 31(10):e3831. https://doi.org/10.1002/nbm.3831

Article  PubMed  Google Scholar 

Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM (2003) p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11(3):577–590. https://doi.org/10.1016/s1097-2765(03)00050-9

Article  CAS  PubMed  Google Scholar 

Ponnapalli SP, Bradley MW, Devine K, Bowen J, Coppens SE, Leraas KM, Milash BA, Li F, Luo H, Qiu S, Wu K, Yang H, Wittwer CT, Palmer CA, Jensen RL, Gastier-Foster JM, Hanson HA, Barnholtz-Sloan JS, Alter O (2020) Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival. APL Bioeng 4(2):026106. https://doi.org/10.1063/1.5142559

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif