May SM, Li JT (2015) Burden of chronic obstructive pulmonary disease: healthcare costs and beyond. Allergy Asthma Proc 36:4–10
Article PubMed PubMed Central Google Scholar
Barnes PJ, Burney PGJ, Silverman EK, Celli BR, Vestbo J, Wedzicha JA, Wouters EFM (2015) Chronic obstructive pulmonary disease. Nat Rev Primers 1:1–21
Adeloye D, Song P, Zhu Y et al (2022) Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med 10(5):447–458
Article PubMed PubMed Central Google Scholar
Hikichi M, Mizumura K, Maruoka S (2019) Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke. J Thorac Dis 11(Suppl 17):S2129–S2140
Article PubMed PubMed Central Google Scholar
Barnes PJ (2022) Oxidative stress in chronic obstructive pulmonary disease. Antioxidants 11(5):965
Article CAS PubMed PubMed Central Google Scholar
Palikaras K, Lionaki E, Tavernarakis N (2015) Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature 521(7553):525–528
Article CAS PubMed Google Scholar
Lu Y, Li Z, Zhang S et al (2023) Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics 13:736–766
Article CAS PubMed PubMed Central Google Scholar
Ito S, Araya J, Kurita Y et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy 11(3):547–559
Article CAS PubMed PubMed Central Google Scholar
Bi Y, Liu S, Qin X (2024) Fundc1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner. J Adv Res 55:45–60
Article CAS PubMed Google Scholar
Liu R, Xu C, Zhang W, Cao Y, Ye J, Li B, Jia S, Weng L, Liu Y, Liu L, Zheng M (2022) FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia. Cell Death Dis 13(7):634
Article CAS PubMed PubMed Central Google Scholar
Pei Z, Liu Y, Liu S et al (2021) Fundc1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis. Metabolism 122:154840
Article CAS PubMed Google Scholar
Yang HH, Jiang HL, Tao JH et al (2022) Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury. Exp Mol Med 54(11):2077–2091
Article CAS PubMed PubMed Central Google Scholar
Xu W, Deng H, Hu S et al (2021) Role of ferroptosis in lung diseases. J Inflamm Res 14:2079–2090
Article PubMed PubMed Central Google Scholar
Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266–282
Article PubMed PubMed Central Google Scholar
Zheng J, Conrad M (2020) The metabolic underpinnings of ferroptosis. Cell Metab 32(6):920–937
Article CAS PubMed Google Scholar
Belavgeni A, Meyer C, Stumpf J (2020) Ferroptosis and necroptosis in the kidney. Cell Chem Biol 27(4):448–462
Article CAS PubMed Google Scholar
Stockwell BR, Friedmann Angeli JP, Bayir H et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171(2):273–285
Article CAS PubMed PubMed Central Google Scholar
Liu P, Feng Y, Li H et al (2020) Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett 25:10
Article CAS PubMed PubMed Central Google Scholar
Li Y, Cao Y, Xiao J et al (2020) Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury. Cell Death Differ 27(9):2635–2650
Article CAS PubMed PubMed Central Google Scholar
Agustí A, Celli BR, Criner GJ (2023) Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Eur Respir J 61(4):2300239
Article PubMed PubMed Central Google Scholar
Zhang H, Li C, Song X et al (2021) Integrated analysis reveals lung fibrinogen gamma chain as a biomarker for chronic obstructive pulmonary disease. Ann Transl Med 9:1765
Article CAS PubMed PubMed Central Google Scholar
Sasaki M, Chubachi S, Kameyama N (2015) Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro-computed tomography. Am J Physiol Lung Cell Mol Physiol 308:L1039–L1045
Li Y, Yu G, Yuan S et al (2017) Cigarette smoke-induced pulmonary inflammation and autophagy are attenuated in Ephx2-deficient mice. Inflammation 40:497–510
Article CAS PubMed Google Scholar
Li F, Xu M, Wang M et al (2018) Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozoneinduced lung inflammation and emphysema. Respir Res 19:230
Article CAS PubMed PubMed Central Google Scholar
Zeng XL, Yang XN, Liu XJ (2022) Resveratrol attenuates cigarette smoke extract induced cellular senescence in human airway epithelial cells by regulating the miR-34a/SIRT1/NF-κB pathway. Medicine (Baltimore) 101(46):e31944
Article CAS PubMed Google Scholar
Shuxia Z, Ping Z, Xiaoyan Z et al (2025) FB1 causes barrier damage to vascular endothelial cells through ferroptosis by a PINK1/Parkin mediated mitophagy-dependent mechanism. Chem Biol Interact 416:111536
Article CAS PubMed Google Scholar
Christenson SA, Smith BM, Bafadhel M (2022) Chronic obstructive pulmonary disease. Lancet 399(10342):2227–2242
Whitaker RM, Corum D, Beeson CC et al (2016) Mitochondrial biogenesis as a pharmacological target: a new approach to acute and chronic diseases. Annu Rev Pharmacol Toxicol 56:229–249
Article CAS PubMed Google Scholar
Ma L, Chen C, Zhao C et al (2024) Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer. Signal Transduct Target Ther 9(1):64
Article CAS PubMed PubMed Central Google Scholar
Imai H, Matsuoka M, Kumagai T et al (2017) Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis. Curr Top Microbiol Immunol 403:143–170
Dixon SJ, Lemberg KM, Lamprecht MR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060–1072
Comments (0)