Yang IA, Jenkins CR, Salvi SS (2022) Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment. Lancet Respir Med 10(5):497–511
Article CAS PubMed Google Scholar
Agusti A, Vogelmeier C, Faner R (2020) COPD 2020: changes and challenges. Am J Physiol-Lung Cell Mol Physiol 319(5):L879–L883
Article CAS PubMed Google Scholar
Baltazar-Garcia EA, Vargas-Guerrero B, L. E. Gasca-Lozanoand C. M. Gurrola-Diaz (2024) Molecular changes underlying pulmonary emphysema and chronic bronchitis in Chronic Obstructive Pulmonary Disease: An updated review. Histol Histopathol 39(7):805–816
Bonaccorsi DPM, Cutoneand A, Polticelli F et al (2018) The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin. Biometals 31(3):399–414
Ianiro G, L. Rosaand D. P. M. Bonaccorsi et al (2023) Lactoferrin: from the structure to the functional orchestration of iron homeostasis. Biometals 36(3):391–416
Article CAS PubMed Google Scholar
Faherty L, Kenny S, Cloonan SM (2023) Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD. Clin Sci 137(3):219–237
Meng D, Zhuand C, Jia R et al (2022) The molecular mechanism of ferroptosis and its role in COPD. Front Med-Lausanne 9:1052540
Wang B, Timilsena YP, Blanchand E, Adhikari B (2019) Lactoferrin: structure, function, denaturation and digestion. Crit Rev Food Sci 59(4):580–596
Guan S, Zhang S, Liu M et al (2024) Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism. J Dairy Sci 107(8):5316–5329
Article CAS PubMed Google Scholar
Sun S, Zongand W, Jiang L et al (2025) Protective effects and mechanisms of lactoferrin and HIF-1alpha on dry eye syndrome in mice. Exp Eye Res 255:110339
Article CAS PubMed Google Scholar
Hering NA, Luettig J, Krug SM et al (2017) Lactoferrin protects against intestinal inflammation and bacteria-induced barrier dysfunction in vitro. Ann N Y Acad Sci 1405(1):177–188
Article CAS PubMed Google Scholar
Vargas BL, J. A. Borcherdingand M. Frommelt et al (2018) Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance. RESP RES 19(1):42
Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060–1072
Article CAS PubMed PubMed Central Google Scholar
Yang Y, Shen W, Zhang Z et al (2025) FSP1 acts in parallel with GPX4 to inhibit ferroptosis in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 72(5):551–562
Article CAS PubMed Google Scholar
Stockwell BR, A. J. Friedmannand H. Bayir et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171(2):273–285
Article CAS PubMed PubMed Central Google Scholar
Yuan J, Liu R, Ma Y, Zhang Z, Xie Z (2018) Curcumin attenuates airway inflammation and airway remolding by inhibiting NF-kappaB signaling and COX-2 in cigarette smoke-induced COPD mice. Inflammation 41(5):1804–1814
Article CAS PubMed Google Scholar
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402–408
Article CAS PubMed Google Scholar
Liu C, Lu J, Yuan T, Xie L, Zhang L (2023) EPC-exosomal miR-26a-5p improves airway remodeling in COPD by inhibiting ferroptosis of bronchial epithelial cells via PTGS2/PGE2 signaling pathway. Sci Rep 13(1):6126
Article PubMed PubMed Central Google Scholar
Lian N, Zhang Q, Chen J et al (2021) The role of ferroptosis in bronchoalveolar epithelial cell injury induced by cigarette smoke extract. Front Physiol 12:751206
Article PubMed PubMed Central Google Scholar
Zi Y, Wang X, Zi Y et al (2023) Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis. Free Radic Biol Med 200:73–86
Article CAS PubMed Google Scholar
Song H, Jiang L, Yang W et al (2023) Cryptotanshinone alleviates lipopolysaccharide and cigarette smoke-induced chronic obstructive pulmonary disease in mice via the Keap1/Nrf2 axis. Biomed Pharmacother 165:115105
Article CAS PubMed Google Scholar
Zhao Z, Xu Z, Chang J et al (2023) Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis. J Inflamm 20(1):28
Gao J, Liuand H, Wang X et al (2022) Associative analysis of multi-omics data indicates that acetylation modification is widely involved in cigarette smoke-induced chronic obstructive pulmonary disease. Front Med-Lausanne 9:1030644
Cao Z, Zhaoand S, Hu S et al (2024) Screening COPD-related biomarkers and traditional chinese medicine prediction based on bioinformatics and machine learning. Int J Chronic Obstr 19:2073–2095
Vogeland C, Marcotte EM (2012) Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet 13(4):227–232
Anderson KM, Collins MA, Chin R et al (2020) Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk. Nat Commun 11(1):2889
Article CAS PubMed PubMed Central Google Scholar
M. Herband M. Schramm, "Functions of ROS in Macrophages and Antimicrobial Immunity," ANTIOXIDANTS-BASEL,vol. 10,no. 2,2021.
Abad I, Bellesand A, Rodriguez-Largo A et al (2025) Lactoferrin modulates oxidative stress and inflammatory cytokines in a murine model of dysbiosis induced by clindamycin. Biochem Cell Biol 103:1–12
Article CAS PubMed Google Scholar
Asaad GF, Mostafa RE (2022) Lactoferrin mitigates ethanol-induced gastric ulcer via modulation of ROS/ICAM-1/Nrf2 signaling pathway in Wistar rats. Iran J Basic Med Sci 25(12):1522–1527
PubMed PubMed Central Google Scholar
Park SY, Jeong AJ, Kim GY et al (2017) Lactoferrin protects human mesenchymal stem cells from oxidative stress-induced senescence and apoptosis. J Microbiol Biotechnol 27(10):1877–1884
Article CAS PubMed Google Scholar
Burrow H, Kanwar RK, Kanwar JR (2011) Antioxidant enzyme activities of iron-saturated bovine lactoferrin (Fe-bLf) in human gut epithelial cells under oxidative stress. Med Chem 7(3):224–230
Article CAS PubMed Google Scholar
Wang Y, Liu Y, Liu J, Kang R, Tang D (2020) NEDD4L-mediated LTF protein degradation limits ferroptosis. Biochem Biophys Res Commun 531(4):581–587
Article CAS PubMed Google Scholar
Wang J, Xiu M, Wang J, Gao Y, Li Y (2024) METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma. J Hematol Oncol 17(1):78
Article PubMed PubMed Central Google Scholar
Salama RM, Darwish SF, Yehia R et al (2024) Lactoferrin alleviates gentamicin-induced acute kidney injury in rats by suppressing ferroptosis: highlight on ACSL4, SLC7A11, NCOA4, FSP1 pathways and miR-378a-3p, LINC00618 expression. Food Chem Toxicol 193:115027
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