Siegel RL, et al. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48.
Holohan C, et al. Cancer drug resistance: an evolving paradigm. Nat Rev Cancer. 2013;13(10):714–26.
Article CAS PubMed Google Scholar
Szakács G, et al. Targeting multidrug resistance in cancer. Nat Rev Drug Discov. 2006;5(3):219–34.
Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70(3):461–77.
Article CAS PubMed Google Scholar
Joshi H, et al. Genistein: a promising modulator of apoptosis and survival signaling in cancer. Naunyn Schmiedebergs Arch Pharmacol. 2023;396(11):2893–910.
Article CAS PubMed Google Scholar
Joshi H, et al. The pharmacological implications of flavopiridol: an updated overview. Molecules. 2023;28(22):7530.
Article CAS PubMed PubMed Central Google Scholar
Tuli HS, et al. Chemopreventive mechanisms of amentoflavone: recent trends and advancements. Naunyn Schmiedebergs Arch Pharmacol. 2023;396(5):865–76.
Article CAS PubMed Google Scholar
Nandini D, et al. Sulforaphane in broccoli: the green chemoprevention!! Role in cancer prevention and therapy. J Oral Maxillofac Pathol JOMFP. 2020;24(2):405.
Article CAS PubMed Google Scholar
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15:195–218.
Article CAS PubMed Google Scholar
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493–506.
Article CAS PubMed Google Scholar
Myzak MC, et al. Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med. 2007;232(2):227–34.
Dinkova-Kostova AT, et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci. 2002;99(18):11908–13.
Article CAS PubMed PubMed Central Google Scholar
Alumkal JJ, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33:480–9.
Article CAS PubMed Google Scholar
Bose C, et al. Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. PLoS ONE. 2018;13(3): e0193918.
Article PubMed PubMed Central Google Scholar
Bansal M, et al. Chemopreventive role of dietary phytochemicals in colorectal cancer. Adv Mol Toxicol. 2018;12:69–121.
Janczewski Ł. Sulforaphane and its bifunctional analogs: Synthesis and biological activity. Molecules. 2022;27(5):1750.
Article CAS PubMed PubMed Central Google Scholar
Vo D-V, et al. A new and effective approach to the synthesis of sulforaphane. Lett Org Chem. 2016;13(1):7–10.
Wang H, et al. Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes. Mol Pharm. 2012;9(10):2819–27.
Article CAS PubMed PubMed Central Google Scholar
Pawlik A, et al. Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells. Phytomedicine. 2017;29:1–10.
Article CAS PubMed Google Scholar
Peng F, et al. Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Signal Transduct Target Ther. 2022;7(1):286.
Article CAS PubMed PubMed Central Google Scholar
Mollinedo F, Gajate C. Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. Drug Resist Updates. 2006;9(1–2):51–73.
Arcidiacono P, et al. Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells. Eur J Nutr. 2018;57:2547–69.
Article CAS PubMed Google Scholar
Bi X, et al. METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246. Cell Death Discov. 2021;7(1):237.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, et al. Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. NPJ Breast Cancer. 2022;8(1):40.
Article PubMed PubMed Central Google Scholar
Kan SF, Wang J, Sun GX. Sulforaphane regulates apoptosis-and proliferation-related signaling pathways and synergizes with cisplatin to suppress human ovarian cancer. Int J Mol Med. 2018;42(5):2447–58.
CAS PubMed PubMed Central Google Scholar
Choi S, et al. d,l-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. Carcinogenesis. 2007;28(1):151–62.
Article CAS PubMed Google Scholar
Wang Y, et al. Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells. Sci Rep. 2021;11(1):2504.
Article CAS PubMed PubMed Central Google Scholar
Singh AV, et al. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis. 2004;25(1):83–90.
Article CAS PubMed Google Scholar
Yamada A, et al. Dual role of Fas/FasL-mediated signal in peripheral immune tolerance. Front Immunol. 2017;8:403.
Article PubMed PubMed Central Google Scholar
Kaboli PJ, et al. Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer–contradictory effects and future perspectives. Biomed Pharmacother. 2020;121: 109635.
Yu H-Y, et al. Sulforaphene suppressed cell proliferation and promoted apoptosis of COV362 cells in endometrioid ovarian cancer. PeerJ. 2023;11:e16308.
Article PubMed PubMed Central Google Scholar
Lewinska A, et al. Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells. Theranostics. 2017;7(14):3461.
Article CAS PubMed PubMed Central Google Scholar
Pledgie-Tracy A, Sobolewski MD, Davidson NE. Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther. 2007;6(3):1013–21.
Comments (0)