Maru SY, Jaffee EM. Pancreatic cancer is feeling the heat. J Immunother Cancer. 2024;12(10):e010124.

Bryce C, Bucaj M. Pancreatic cancer: rapid evidence review. Am Family Phys. 2024;109(3):245–50.

Google Scholar 

Martin RF. Management of pancreatic cancer. Surg Clin North Am. 2024;104(5):xiii–xv.

Article  PubMed  Google Scholar 

Jinno N, Yoshida M, Hayashi K, Naitoh I, Hori Y, Natsume M, Kato A, Kachi K, Asano G, Atsuta N, et al. Autotaxin in Ascites promotes peritoneal dissemination in pancreatic cancer. Cancer Sci. 2021;112(2):668–78.

Article  CAS  PubMed  Google Scholar 

Gravallese EM, Firestein GS, Koscal N, Ling E, Longo DL, Messenger LA, Schubach A. What is rheumatoid arthritis? N Engl J Med. 2024;390(13):e32.

Article  PubMed  Google Scholar 

Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W, Watts GFM, Weisenfeld D, et al. Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature. 2023;623(7987):616–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu X, Peng H, Wen Y, Cai X, Li C, Zhong R, Huang Y, Chen J, Huo Z, Wang R, et al. Rheumatoid arthritis and risk of lung cancer: Meta-analysis and Mendelian randomization study. Semin Arthritis Rheum. 2021;51(3):565–75.

Article  CAS  PubMed  Google Scholar 

Simon TA, Thompson A, Gandhi KK, Hochberg MC, Suissa S. Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis. Arthritis Res Therapy. 2015;17(1):212.

Article  Google Scholar 

Askling J, Fored CM, Baecklund E, Brandt L, Backlin C, Ekbom A, Sundström C, Bertilsson L, Cöster L, Geborek P, et al. Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists. Ann Rheum Dis. 2005;64(10):1414–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan S, Carter P, Bruzelius M, Vithayathil M, Kar S, Mason AM, Lin A, Burgess S, Larsson SC. Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study. EBioMedicine. 2020;59:102956.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014;23(R1):R89–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burgess S, Small DS, Thompson SG. A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res. 2017;26(5):2333–55.

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT, Timpson NJ, Dimou N, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. JAMA. 2021;326(16):1614–21.

Article  PubMed  Google Scholar 

Palmer TM, Lawlor DA, Harbord RM, Sheehan NA, Tobias JH, Timpson NJ, Davey Smith G, Sterne JA. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res. 2012;21(3):223–42.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent Estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14.

Article  PubMed  PubMed Central  Google Scholar 

Yuan S, Chen J, Ruan X, Vithayathil M, Kar S, Li X, Mason AM, Burgess S, Larsson SC. Rheumatoid arthritis and risk of site-specific cancers: Mendelian randomization study in European and East Asian populations. Arthritis Res Therapy. 2022;24(1):270.

Article  CAS  Google Scholar 

Hashimoto A, Chiba N, Tsuno H, Komiya A, Furukawa H, Matsui T, Nishino J, Tohma S. Incidence of malignancy and the risk of lymphoma in Japanese patients with rheumatoid arthritis compared to the general population. J Rhuematol. 2015;42(4):564–71.

Article  CAS  Google Scholar 

Adebayo M, Singh S, Singh AP, Dasgupta S. Mitochondrial fusion and fission: the fine-tune balance for cellular homeostasis. Faseb J. 2021;35(6):e21620.

Article  CAS  PubMed  Google Scholar 

Yan C, Shi Y, Yuan L, Lv D, Sun B, Wang J, Liu X, An F. Mitochondrial quality control and its role in osteoporosis. Front Endocrinol. 2023;14:1077058.

Article  Google Scholar 

Cui L, Weiyao J, Chenghong S, Limei L, Xinghua Z, Bo Y, Xiaozheng D, Haidong W. Rheumatoid arthritis and mitochondrial homeostasis: the crossroads of metabolism and immunity. Front Med. 2022;9:1017650.

Article  Google Scholar 

An HJ, Ryu M, Jeong HJ, Kang M, Jeon HM, Lee JO, Kim YS, Lee H. Higd-1a regulates the proliferation of pancreatic cancer cells through a pERK/p27(KIP1)/pRB pathway. Cancer Lett. 2019;461:78–89.

Article  CAS  PubMed  Google Scholar 

Courtois S, de Luxán-Delgado B, Penin-Peyta L, Royo-García A, Parejo-Alonso B, Jagust P, Alcalá S, Rubiolo JA, Sánchez L, Sainz B, editors. Jr. Inhibition of mitochondrial dynamics preferentially targets pancreatic cancer cells with enhanced tumorigenic and invasive potential. Cancers (Basel). 2021;13(4).

Bishop EL, Gudgeon N, Fulton-Ward T, Stavrou V, Roberts J, Boufersaoui A, Tennant DA, Hewison M, Raza K, Dimeloe S. TNF-α signals through ITK-Akt-mTOR to drive CD4(+) T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis. Sci Signal. 2024;17(833):eadg5678.

Article  CAS  PubMed  Google Scholar 

Chumak V, Rajacharya GH, Singh PK. Metabolomic investigations into Hypoxia-Mediated metabolic reprogramming of pancreatic cancer cells. Methods Mol Biology (Clifton NJ). 2024;2755:191–200.

Article  CAS  Google Scholar 

Willemsen J, Neuhoff MT, Hoyler T, Noir E, Tessier C, Sarret S, Thorsen TN, Littlewood-Evans A, Zhang J, Hasan M, et al. TNF leads to MtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis. Cell Rep. 2021;37(6):109977.

Article  CAS  PubMed  Google Scholar 

Schwörer S, Cimino FV, Ros M, Tsanov KM, Ng C, Lowe SW, Carmona-Fontaine C, Thompson CB. Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer Cell-Derived cytokines. Cancer Res. 2023;83(10):1596–610.

Article  PubMed  PubMed Central  Google Scholar 

Yu D, Du J, Pu X, Zheng L, Chen S, Wang N, Li J, Chen S, Pan S, Shen B. The gut Microbiome and metabolites are altered and interrelated in patients with rheumatoid arthritis. Front Cell Infect Microbiol. 2021;11:763507.

Article  CAS  PubMed  Google Scholar 

Papa V, Schepis T, Coppola G, Chiappetta MF, Del Vecchio LE, Rozera T, Quero G, Gasbarrini A, Alfieri S, Papa A. The role of microbiota in pancreatic cancer. Cancers (Basel). 2023;15(12):3143.

Zhang Y, Zhang H, Liu B, Ning K. Highly accurate diagnosis of pancreatic cancer by integrative modeling using gut Microbiome and exposome data. iScience. 2024;27(3):109294.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu J, Wu B, Goodman SB, Berry GJ, Goronzy JJ, Weyand CM. Metabolic control of autoimmunity and tissue inflammation in rheumatoid arthritis. Front Immunol. 2021;12:652771.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noto CN, Hoft SG, DiPaolo RJ. Mast cells as important regulators in autoimmunity and cancer development. Front Cell Dev Biol. 2021;9:752350.

Article  PubMed  PubMed Central  Google Scholar 

Luo S, Li W, Li Q, Zhang M, Wang X, Wu S, Li Y. Causal effects of gut microbiota on the risk of periodontitis: a two-sample Mendelian randomization study. Front Cell Infect Microbiol. 2023;13:1160993.

Article  PubMed  PubMed Central  Google Scholar 

Yang M, Wan X, Zheng H, Xu K, Xie J, Yu H, Wang J, Xu P. No evidence of a genetic causal relationship between ankylosing spondylitis and gut microbiota: a two-sample Mendelian randomization study. Nutrients. 2023;15(4)1057.