Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, et al. Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation. Cell Mol Immunol. 2023;20:1127–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taylor A, Rudd CE. Commentary: Small Molecule Inhibition of PD-1 Transcription is an Effective Alternative to Antibody Blockade in Cancer Therapy. J Immunol Sci. 2019;3:9–12.

PubMed  PubMed Central  Google Scholar 

Taylor A, Rudd CE. Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8(+) Cytotoxic T Cells: Implications for anti-PD-1 Immunotherapy. Front Immunol. 2017;8:1653.

PubMed  PubMed Central  Google Scholar 

Taylor A, Harker JA, Chanthong K, Stevenson PG, Zuniga EI, Rudd CE. Glycogen synthase kinase 3 inactivation drives T-bet-mediated downregulation of coreceptor PD-1 to enhance CD8(+) cytolytic T-cell responses. Immunity. 2016;44:274–86.

CAS  PubMed  PubMed Central  Google Scholar 

Huntington KE, Louie AD, Srinivasan PR, Schorl C, Lu S, Silverberg D, et al. GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer. Int J Mol Sci. 2023;24:10870.

CAS  PubMed  PubMed Central  Google Scholar 

Ye Z, Gould TM, Zhang H, Jin J, Weyand CM, Goronzy JJ. The GSK3beta-beta-catenin-TCF1 pathway improves naive T-cell activation in old adults by upregulating miR-181a. NPJ Aging Mech Dis. 2021;7:4.

CAS  PubMed  PubMed Central  Google Scholar 

Sengupta S, Katz SC, Sengupta S, Sampath P. Glycogen synthase kinase 3 inhibition lowers PD-1 expression, promotes long-term survival and memory generation in antigen-specific CAR-T cells. Cancer Lett. 2018;433:131–9.

CAS  PubMed  Google Scholar 

Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, et al. Granzyme B and perforin are important for regulatory T-cell-mediated suppression of tumor clearance. Immunity. 2007;27:635–46.

CAS  PubMed  Google Scholar 

Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, et al. Glycogen synthase kinase 3 drives thymocyte egress by suppressing beta-catenin activation of Akt. Sci Adv. 2021;7:eabg6262.

CAS  PubMed  PubMed Central  Google Scholar 

Sengupta S. Unrestrained glycogen synthase kinase-3β activity leads to activated T-cell death and can be inhibited by natural adjuvant. J Immunol. 2007;178:6083–91.

CAS  PubMed  Google Scholar 

Wherry EJ. T-cell exhaustion. Nature Immunol. 2011;12:492–9.

CAS  Google Scholar