Weiss F, Lauffenburger D, Friedl P. Towards targeting of shared mechanisms of cancer metastasis and therapy resistance. Nat Rev Cancer. 2022;22:157–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–5.

Article  CAS  PubMed  Google Scholar 

Muniz VS, Silva JC, Braga Y, Melo R, Ueki S, Takeda M, et al. Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus. J Allergy Clin Immunol. 2018;141:571–585.e577.

Article  CAS  PubMed  Google Scholar 

Chapman EA, Lyon M, Simpson D, Mason D, Beynon RJ, Moots RJ, et al. Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus. Front Immunol. 2019;10:423.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mutua V, Gershwin LJ. A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics. Clin Rev Allergy Immunol. 2021;61:194–211.

Article  CAS  PubMed  Google Scholar 

Cools-Lartigue J, Spicer J, Najmeh S, Ferri L. Neutrophil extracellular traps in cancer progression. Cell Mol Life Sci. 2014;71:4179–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masucci MT, Minopoli M, Del Vecchio S, Carriero MV. The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis. Front Immunol. 2020;11:1749.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tohme S, Yazdani HO, Al-Khafaji AB, Chidi AP, Loughran P, Mowen K, et al. Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress. Cancer Res. 2016;76:1367–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yazdani HO, Roy E, Comerci AJ, van der Windt DJ, Zhang H, Huang H, et al. Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth. Cancer Res. 2019;79:5626–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rayes RF, Vourtzoumis P, Bou Rjeily M, Seth R, Bourdeau F, Giannias B, et al. Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma. J Immunol. 2020;204:2285–94.

Article  CAS  PubMed  Google Scholar 

Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, et al. Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res. 2012;72:3919–27.

Article  CAS  PubMed  Google Scholar 

McDowell SAC, Luo R, Arabzadeh A, Doré S, Bennett NC, Breton V, et al. Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration. Nat Cancer. 2021;2:545–62.

Article  CAS  PubMed  Google Scholar 

Yadav R, Momin A, Godugu C. DNase based therapeutic approaches for the treatment of NETosis related inflammatory diseases. Int Immunopharmacol. 2023;124:110846.

Article  CAS  PubMed  Google Scholar 

Filipczak N, Li X, Saawant GR, Yalamarty S, Luther E, Torchilin VP. Antibody-modified DNase I micelles specifically recognize the neutrophil extracellular traps (NETs) and promote their degradation. J Control Release. 2023;354:109–19.

Article  CAS  PubMed  Google Scholar 

Rahman S, Gadjeva M. Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?. Front Immunol. 2014;5:378.

Article  PubMed  PubMed Central  Google Scholar 

Najmeh S, Cools-Lartigue J, Rayes RF, Gowing S, Vourtzoumis P, Bourdeau F, et al. Neutrophil extracellular traps sequester circulating tumor cells via β1-integrin mediated interactions. Int J Cancer. 2017;140:2321–30.

Article  CAS  PubMed  Google Scholar 

Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, et al. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med. 2016;8:361ra138.

Article  PubMed  PubMed Central  Google Scholar 

Kolaczkowska E, Jenne CN, Surewaard BG, Thanabalasuriar A, Lee WY, Sanz MJ, et al. Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature. Nat Commun. 2015;6:6673.

Article  PubMed  Google Scholar 

Lande R, Ganguly D, Facchinetti V, Frasca L, Conrad C, Gregorio J, et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Science Transl Med. 2011;3:73ra19.

Article  Google Scholar 

Tsokos GC, Lo MS, Costa Reis P, Sullivan KE. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. 2016;12:716–30.

Article  CAS  PubMed  Google Scholar 

Qiu SL, Zhang H, Tang QY, Bai J, He ZY, Zhang JQ, et al. Neutrophil extracellular traps induced by cigarette smoke activate plasmacytoid dendritic cells. Thorax. 2017;72:1084–93.

Article  PubMed  Google Scholar 

Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2017;17:97–111.

Article  CAS  PubMed  Google Scholar 

Wang C, Zhang R, He J, Yu L, Li X, Zhang J, et al. Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity. Nat Commun. 2023;14:3877.

Gehrke N, Mertens C, Zillinger T, Wenzel J, Bald T, Zahn S, et al. Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity. 2013;39:482–95.

Article  CAS  PubMed  Google Scholar 

Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, et al. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature. 2020;583:133–8.

Article  CAS  PubMed  Google Scholar 

Wang Z, Chen C, Shi C, Zhao X, Gao L, Guo F, et al. Cell membrane derived liposomes loaded with DNase I target neutrophil extracellular traps which inhibits colorectal cancer liver metastases. J Control Release. 2023;357:620–9.

Article  CAS  PubMed  Google Scholar 

Vogel A, Katzka CP, Waldmann H, Arnold K, Brown MF, Huster D. Lipid modifications of a Ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR. J Am Chem Soc. 2005;127:12263–72.

Article  CAS  PubMed  Google Scholar 

Chang RS, Suh MS, Kim S, Shim G, Lee S, Han SS, et al. Cationic drug-derived nanoparticles for multifunctional delivery of anticancer siRNA. Biomaterials. 2011;32:9785–95.

Article  CAS  PubMed  Google Scholar 

Ellis JA, Cooke J, Singh-Moon RP, Wang M, Bruce JN, Emala CW, et al. Safety, feasibility, and optimization of intra-arterial mitoxantrone delivery to gliomas. J Neurooncol. 2016;130:449–54.

Article  CAS  PubMed  Google Scholar 

Vollmer T, Stewart T, Baxter N. Mitoxantrone and cytotoxic drugs’ mechanisms of action. Neurology. 2010;74:S41–S46.

Article  CAS  PubMed  Google Scholar 

Bagheri Y, Chedid S, Shafiei F, Zhao B, You M. A quantitative assessment of the dynamic modification of lipid-DNA probes on live cell membranes. Chem Sci. 2019;10:11030–40.

Article  CAS  PubMed  PubMed Central