Bafadhel M, Peterson S, De Blas MA et al (2018) Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials. Lancet Respir Med 6(2):117–126
Article CAS PubMed Google Scholar
Lipson DA, Barnhart F, Brealey N et al (2018) Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med 378(18):1671–1680
Article CAS PubMed Google Scholar
Brusselle G, Pavord ID, Landis S et al (2018) Blood eosinophil levels as a biomarker in COPD. Respir Med 138:21–31
Halpin DMG, Healey H, Skinner D, Carter V, Pullen R, Price D (2024) Exacerbation history and blood eosinophil count prior to diagnosis of COPD and risk of subsequent exacerbations. Eur Respir J. https://doi.org/10.1183/13993003.02240-2023
Article PubMed PubMed Central Google Scholar
Zhu D, Dai H, Zhu H et al (2023) Identification of frequent acute exacerbations phenotype in COPD patients based on imaging and clinical characteristics. Respir Med 209:107150
Baraldi F, Bartlett-Pestle S, Allinson JP et al (2025) Blood eosinophil count stability in COPD and the eosinophilic exacerbator phenotype. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.202407-1287RL
Papaporfyriou A, Bakakos P, Hillas G, Papaioannou AI, Loukides S (2022) Blood eosinophils in COPD: friend or foe? Expert Rev Respir Med 16(1):35–41
Article CAS PubMed Google Scholar
Bartoli ML, Latorre M, Vagaggini B et al (2021) Are sputum eosinophils associated with a different phenotype in COPD patients? A retrospective study. Respir Med 190:106672
Beech A, Booth S, Higham A, Singh D (2024) Current smoking reduces small airway eosinophil counts in COPD. ERJ Open Res. https://doi.org/10.1183/23120541.00870-2023
Article PubMed PubMed Central Google Scholar
Enriquez-Rodriguez CJ, Casadevall C, Faner R et al (2024) COPD: systemic proteomic profiles in frequent and infrequent exacerbators. ERJ Open Res. https://doi.org/10.1183/23120541.00004-2024
Article PubMed PubMed Central Google Scholar
Agusti A, Hughes R, Rapsomaki E et al (2024) The many faces of COPD in real life: a longitudinal analysis of the NOVELTY cohort. ERJ Open Res. https://doi.org/10.1183/23120541.00895-2023
Article PubMed PubMed Central Google Scholar
Bathoorn E, Kerstjens H, Postma D, Timens W, MacNee W (2008) Airways inflammation and treatment during acute exacerbations of COPD. Int J Chron Obstruct Pulmon Dis 3(2):217–229
Article PubMed PubMed Central Google Scholar
Gao P, Zhang J, He X, Hao Y, Wang K, Gibson PG (2013) Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. PLoS ONE 8(5):e57678
Article CAS PubMed PubMed Central Google Scholar
MacDonald MI, Osadnik CR, Bulfin L et al (2021) MULTI-PHACET: multidimensional clinical phenotyping of hospitalised acute COPD exacerbations. ERJ Open Res. https://doi.org/10.1183/23120541.00198-2021
Article PubMed PubMed Central Google Scholar
Zeng Q, Wang H, Wang K, Zhou H, Wang T, Wen F (2021) Eosinophilic phenotype was associated with better early clinical remission in elderly patients but not middle-aged patients with acute exacerbations of COPD. Int J Clin Pract 75(9):e14415
Article CAS PubMed Google Scholar
Colak Y, Afzal S, Nordestgaard BG, Lange P (2016) Majority of never-smokers with airflow limitation do not have asthma: the Copenhagen General Population Study. Thorax 71(7):614–623
Disease GIfCOL. Global strategy for prevention, diagnosis and management of COPD: 2023 Report. In: Global Initiative for Chronic Obstructive Lung Disease; 2023.
Singh D, Agusti A, Martinez FJ et al (2022) Blood eosinophils and chronic obstructive pulmonary disease: a global initiative for chronic obstructive lung disease science committee 2022 review. Am J Respir Crit Care Med 206(1):17–24
Article CAS PubMed Google Scholar
Ouaalaya EH, Falque L, Dupis JM et al (2020) Susceptibility to frequent exacerbation in COPD patients: Impact of the exacerbations history, vaccinations and comorbidities? Respir Med 169:106018
Gonzalez-Barcala FJ, San-Jose ME, Nieto-Fontarigo JJ et al (2019) Blood eosinophils could be useful as a biomarker in chronic obstructive pulmonary disease exacerbations. Int J Clin Pract. https://doi.org/10.1111/ijcp.13423
Bafadhel M, Greening NJ, Harvey-Dunstan TC et al (2016) Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD. Chest 150(2):320–328
Article CAS PubMed Google Scholar
Ko FWS, Chan KP, Ngai J et al (2020) Blood eosinophil count as a predictor of hospital length of stay in COPD exacerbations. Respirology 25(3):259–266
Singh D, Hurst JR, Martinez FJ et al (2022) Predictive modeling of COPD exacerbation rates using baseline risk factors. Ther Adv Respir Dis 16:17534666221107314
Article PubMed PubMed Central Google Scholar
Van Rossem I, Vandevoorde J, Hanon S, Deridder S, Vanderhelst E (2020) The stability of blood eosinophils in stable chronic obstructive pulmonary disease: a retrospective study in Belgian primary care. BMC Pulm Med 20(1):200
Article PubMed PubMed Central Google Scholar
Vogelmeier CF, Kostikas K, Fang J et al (2019) Evaluation of exacerbations and blood eosinophils in UK and US COPD populations. Respir Res 20(1):178
Article PubMed PubMed Central Google Scholar
Schumann DM, Tamm M, Kostikas K, Stolz D (2019) Stability of the Blood Eosinophilic Phenotype in Stable and Exacerbated COPD. Chest 156(3):456–465
Spector SL, Tan RA (2012) Is a single blood eosinophil count a reliable marker for “eosinophilic asthma?” J Asthma 49(8):807–810
Miravitlles M, Monteagudo M, Solntseva I, Alcazar B (2020) Blood eosinophil counts and their variability and risk of exacerbations in COPD: a population-based study. Arch Bronconeumol. https://doi.org/10.1016/j.arbres.2019.12.015
Zhang Y, Liang LR, Zhang S et al (2020) Blood eosinophilia and its stability in hospitalized COPD exacerbations are associated with lower risk of all-cause mortality. Int J Chron Obstruct Pulmon Dis 15:1123–1134
Article PubMed PubMed Central Google Scholar
Shin SH, Park HY, Kang D et al (2018) Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease. Respir Res 19(1):134
Article PubMed PubMed Central Google Scholar
Kwok WC, Chau CH, Tam TCC, Lam FM, Ho JCM (2023) Variability of blood eosinophil count at stable-state in predicting exacerbation risk of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 18:1145–1153
Article PubMed PubMed Central Google Scholar
Garcia-Sanz MT, Canive-Gomez JC, Garcia-Couceiro N et al (2017) Factors associated with the incidence of serious adverse events in patients admitted with COPD acute exacerbation. Ir J Med Sci 186(2):477–483
Article CAS PubMed Google Scholar
MacDonald MI, Osadnik CR, Bulfin L et al (2019) Low and high blood eosinophil counts as biomarkers in hospitalized acute
Comments (0)