Plasma Reticulocalbin 3 (RCN3) is a Novel Biomarker for the Early Diagnosis of Hepatopulmonary Syndrome in Cirrhotic Patients

Thévenot T, Weil D, Garioud A, Lison H, Cadranel JF, Degano B (2016) Hepatopulmonary syndrome. Presse Med 45:509–514. https://doi.org/10.1016/j.lpm.2016.02.017

Article  PubMed  Google Scholar 

Qasim A, Jyala A, Shrivastava S, Allena N, Ghazanfar H, Bhatt V, Ali HR, Vakde T, Patel H (2024) Hepatopulmonary syndrome: a comprehensive review. Cureus 16:e65204. https://doi.org/10.7759/cureus.65204

Article  PubMed  PubMed Central  Google Scholar 

Zhao X, Kotha S, Nayyar D, Ma X, Lilly L, Castel H, Gupta S (2024) Physiologic changes in the hepatopulmonary syndrome before and after liver transplant: a longitudinal and predictor analysis. Hepatology 79:636–649. https://doi.org/10.1097/hep.0000000000000605

Article  PubMed  Google Scholar 

Eshraghian A, Kamyab AA, Yoon SK (2013) Pharmacological treatment for hepatopulmonary syndrome. Biomed Res Int 2013:670139. https://doi.org/10.1155/2013/670139

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koch DG, Fallon MB (2014) Hepatopulmonary syndrome. Curr Opin Gastroenterol 30:260–264. https://doi.org/10.1097/MOG.0000000000000067

Article  PubMed  Google Scholar 

Zhang J, Fallon MB (2012) Hepatopulmonary syndrome: update on pathogenesis and clinical features. Nat Rev Gastroenterol Hepatol 9:539–549. https://doi.org/10.1038/nrgastro.2012.123

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang CC, Wang SS, Hsieh HG, Lee WS, Chuang CL, Lin HC, Lee FY, Lee SD, Huang HC (2015) Rosuvastatin improves hepatopulmonary syndrome through inhibition of inflammatory angiogenesis of lung. Clin Sci (Lond) 129:449–460. https://doi.org/10.1042/cs20140622

Article  CAS  PubMed  Google Scholar 

Zhang J, Luo B, Tang L, Wang Y, Stockard CR, Kadish I, Van Groen T, Grizzle WE, Ponnazhagan S, Fallon MB (2009) Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Gastroenterology 136:1070–1080. https://doi.org/10.1053/j.gastro.2008.12.001

Article  CAS  PubMed  Google Scholar 

Ling Y, Zhang J, Luo B, Song D, Liu L, Tang L, Stockard CR, Grizzle WE, Ku DD, Fallon MB (2004) The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat. Hepatology 39:1593–1602. https://doi.org/10.1002/hep.20244

Article  CAS  PubMed  Google Scholar 

Zhang J, Yang W, Hu B, Wu W, Fallon MB (2014) Endothelin-1 activation of the endothelin B receptor modulates pulmonary endothelial CX3CL1 and contributes to pulmonary angiogenesis in experimental hepatopulmonary syndrome. Am J Pathol 184:1706–1714. https://doi.org/10.1016/j.ajpath.2014.02.027

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baweja S, Kumari A, Negi P, Tomar A, Tripathi DM, Mourya AK, Rastogi A, Subudhi PD, Thangariyal S, Kumar G, Kumar J, Reddy GS, Sood AK, Vashistha C, Sarohi V, Bihari C, Maiwall R, Sarin SK (2023) Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod. J Hepatol 79:167–180. https://doi.org/10.1016/j.jhep.2023.03.018

Article  CAS  PubMed  Google Scholar 

Robert F, Certain MC, Baron A, Thuillet R, Duhaut L, Ottaviani M, Chelgham MK, Normand C, Berrebeh N, Ricard N, Furlan V, Desroches-Castan A, Gonzales E, Jacquemin E, Sitbon O, Humbert M, Bailly S, Coilly A, Guignabert C, Tu L, Savale L (2024) Disrupted BMP-9 signaling impairs pulmonary vascular integrity in hepatopulmonary syndrome. Am J Respir Crit Care Med 210:648–661. https://doi.org/10.1164/rccm.202307-1289OC

Article  CAS  PubMed  Google Scholar 

Ding F, Wang Z, Wang J, Ma Y, Jin J (2024) Serum S1P level in interstitial lung disease (ILD) is a potential biomarker reflecting the severity of pulmonary function. BMC Pulm Med. https://doi.org/10.1186/s12890-024-03081-y

Article  PubMed  PubMed Central  Google Scholar 

Jiang Q, Liu C, Liu S, Lu W, Li Y, Luo X, Ma R, Zhang C, Chen H, Chen Y, Zhang Z, Hong C, Guo W, Wang T, Yang K, Wang J (2021) Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats. Br J Pharmacol 178:203–216. https://doi.org/10.1111/bph.15285

Article  CAS  PubMed  Google Scholar 

Yanagihara T, Tsubouchi K, Zhou Q, Chong M, Otsubo K, Isshiki T, Schupp JC, Sato S, Scallan C, Upagupta C, Revill S, Ayoub A, Chong SG, Dvorkin-Gheva A, Kaminski N, Tikkanen J, Keshavjee S, Paré G, Guignabert C, Ask K, Kolb MRJ (2023) Vascular-parenchymal cross-talk promotes lung fibrosis through bmpr2 signaling. Am J Respir Crit Care Med 207:1498–1514. https://doi.org/10.1164/rccm.202109-2174OC

Article  CAS  PubMed  Google Scholar 

Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF (2014) The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Am J Respir Crit Care Med 190:1032–1043. https://doi.org/10.1164/rccm.201401-0121OC

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nikolic I, Yung LM, Yang P, Malhotra R, Paskin-Flerlage SD, Dinter T, Bocobo GA, Tumelty KE, Faugno AJ, Troncone L, McNeil ME, Huang X, Coser KR, Lai CSC, Upton PD, Goumans MJ, Zamanian RT, Elliott CG, Lee A, Zheng W, Berasi SP, Huard C, Morrell NW, Chung RT, Channick RW, Roberts KE, Yu PB (2019) Bone morphogenetic protein 9 Is a mechanistic biomarker of portopulmonary hypertension. Am J Respir Crit Care Med 199:891–902. https://doi.org/10.1164/rccm.201807-1236OC

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuji A, Kikuchi Y, Sato Y, Koide S, Yuasa K, Nagahama M, Matsuda Y (2006) A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4. Biochem J 396:51–59. https://doi.org/10.1042/bj20051524

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin J, Li Y, Ren J, Man Lam S, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ (2016) Neonatal respiratory failure with retarded perinatal lung maturation in mice caused by reticulocalbin 3 disruption. Am J Respir Cell Mol Biol 54:410–423. https://doi.org/10.1165/rcmb.2015-0036OC

Article  CAS  PubMed  Google Scholar 

Jin J, Shi X, Li Y, Zhang Q, Guo Y, Li C, Tan P, Fang Q, Ma Y, Ma RZ (2018) Reticulocalbin 3 deficiency in alveolar epithelium exacerbated bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 59:320–333. https://doi.org/10.1165/rcmb.2017-0347OC

Article  CAS  PubMed  Google Scholar 

Ding F, Yang L, Wang Y, Wang J, Ma Y, Jin J (2023) Serum Rcn3 level is a potential diagnostic biomarker for connective tissue disease-associated interstitial lung disease and reflects the severity of pulmonary function. BMC Pulm Med 23:68. https://doi.org/10.1186/s12890-023-02360-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi X, An X, Yang L, Wu Z, Zan D, Li Z, Pang B, Chen Y, Li J, Tan P, Ma RZ, Fang Q, Ma Y, Jin J (2021) Reticulocalbin 3 deficiency in alveolar epithelium attenuated LPS-induced ALI via NFκB signaling. Am J Physiol Lung Cell Mol Physiol. https://doi.org/10.1152/ajplung.00526.2020

Article  PubMed  PubMed Central  Google Scholar 

Wu M, Wang Z, Shi X, Zan D, Chen H, Yang S, Ding F, Yang L, Tan P, Ma RZ, Wang J, Ma L, Ma Y, Jin J (2023) TGFbeta1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation. Respir Res 24:222. https://doi.org/10.1186/s12931-023-02533-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawut SM, Krowka MJ, Forde KA, Al-Naamani N, Krok KL, Patel M, Bartoli CR, Doyle M, Moutchia J, Lin G, Oh JK, Mottram CD, Scanlon PD, Fallon MB (2022) Impact of hepatopulmonary syndrome in liver transplantation candidates and the role of angiogenesis. Eur Respir J. https://doi.org/10.1183/13993003.02304-2021

Article  PubMed  PubMed Central  Google Scholar 

Li YJ, Wu XF, Wang DD, Li P, Liang H, Hu XY, Gan JQ, Sun YZ, Li JH, Li J, Shu X, Song AL, Yang CY, Yang ZY, Yu WF, Yang LQ, Wang XB, Belguise K, Xia ZY, Yi B (2023) Serum soluble vascular endothelial growth factor receptor 1 as a potential biomarker of hepatopulmonary syndrome. J Clin Transl Hepatol 11:1150–1160. https://doi.org/10.14218/jcth.2022.00421

Article  PubMed  PubMed Central 

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