Webb PM, Jordan SJ. Global epidemiology of epithelial ovarian cancer. Nat Rev Clin Oncol 2024.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30.
Lheureux S, Braunstein M, Oza AM. Epithelial ovarian cancer: evolution of management in the era of precision medicine. CA Cancer J Clin. 2019;69(4):280–304.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA. Invasive epithelial ovarian Cancer survival by Histotype and Disease Stage. J Natl Cancer Inst. 2019;111(1):60–8.
White M, Sears C. The microbial landscape of colorectal cancer. Nat Rev Microbiol 2023.
Routy B, Lenehan JG, Miller WH Jr., Jamal R, Messaoudene M, Daisley BA, Hes C, Al KF, Martinez-Gili L, Punčochář M, et al. Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial. Nat Med. 2023;29(8):2121–32.
Article CAS PubMed Google Scholar
Ling Y, Tian Z, Wu E, Ding L, Pei L. YINDARA-4 relieves visceral hypersensitivity in irritable bowel syndrome rats via regulation of gut microbiota and serotonin levels. Acupunct Herb Med. 2022;2(4):274–83. https://doi.org/10.1097/hm9.0000000000000042.
Ahmed SMH, Maldera JA, Krunic D, Paiva-Silva GO, Pénalva C, Teleman AA, Edgar BA. Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila. Nature. 2020;584(7821):415–9.
Article CAS PubMed PubMed Central Google Scholar
Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: physiological and clinical implications. Maturitas 2017, 103:45–53.
Prakash A, Nourianpour M, Senok A, Atiomo W. Polycystic Ovary Syndrome and Endometrial Cancer: A Scoping Review of the Literature on Gut Microbiota. Cells 2022, 11(19).
Liu X, Chen X, Wang C, Song J, Xu J, Gao Z, Huang Y, Suo H. Mechanisms of probiotic modulation of ovarian sex hormone production and metabolism: a review. Food Funct. 2024;15(6):2860–78.
Article CAS PubMed Google Scholar
Wang L, Tang L, Zhai D, Song M, Li W, Xu S, Jiang S, Meng H, Liang J, Wang Y, et al. The role of the sex hormone-gut microbiome axis in tumor immunotherapy. Gut Microbes. 2023;15(1):2185035.
Article PubMed PubMed Central Google Scholar
Cross TL, Simpson AMR, Lin CY, Hottmann NM, Bhatt AP, Pellock SJ, Nelson ER, Loman BR, Wallig MA, Vivas EI, et al. Gut microbiome responds to alteration in female sex hormone status and exacerbates metabolic dysfunction. Gut Microbes. 2024;16(1):2295429.
Hu X, Xu X, Zeng X, Jin R, Wang S, Jiang H, Tang Y, Chen G, Wei J, Chen T, et al. Gut microbiota dysbiosis promotes the development of epithelial ovarian cancer via regulating hedgehog signaling pathway. Gut Microbes. 2023;15(1):2221093.
Article PubMed PubMed Central Google Scholar
Chalif J, Wang H, Spakowicz D, Quick A, Arthur EK, O’Malley D, Chambers LM. The microbiome and gynecologic cancer: cellular mechanisms and clinical applications. Int J Gynecol Cancer 2023.
Johnson CH, Ivanisevic J, Siuzdak G. Metabolomics: beyond biomarkers and towards mechanisms. Nat Rev Mol Cell Biol. 2016;17(7):451–9.
Article CAS PubMed PubMed Central Google Scholar
Yang C, Lai C, Ru Y, Shen B, Wu X, Cui J, et al. Elucidating the mechanism of hepatotoxicity in Euodia rutaecarpa: insights from QSAR toxicity prediction and metabolomics. Acupunct Herb Med. 2024;4(2):257–70. https://doi.org/10.1097/HM9.0000000000000108.
Zeleznik OA, Clish CB, Kraft P, Avila-Pacheco J, Eliassen AH, Tworoger SS. Circulating lysophosphatidylcholines, Phosphatidylcholines, ceramides, and Sphingomyelins and Ovarian Cancer risk: a 23-Year prospective study. J Natl Cancer Inst. 2020;112(6):628–36.
Zeleznik OA, Eliassen AH, Kraft P, Poole EM, Rosner BA, Jeanfavre S, Deik AA, Bullock K, Hitchcock DS, Avila-Pacheco J, et al. A prospective analysis of circulating plasma metabolites Associated with Ovarian Cancer Risk. Cancer Res. 2020;80(6):1357–67.
Article CAS PubMed PubMed Central Google Scholar
Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017;318(19):1925–6.
Richmond RC, Davey Smith G. Mendelian randomization: concepts and scope. Cold Spring Harb Perspect Med 2022, 12(1).
Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet. 2021;53(2):156–65.
Article CAS PubMed PubMed Central Google Scholar
Lopera-Maya EA, Kurilshikov A, van der Graaf A, Hu S, Andreu-Sánchez S, Chen L, Vila AV, Gacesa R, Sinha T, Collij V, et al. Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. Nat Genet. 2022;54(2):143–51.
Article CAS PubMed Google Scholar
Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH, Yoshiji S, Willett JDS, et al. Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases. Nat Genet. 2023;55(1):44–53.
Article PubMed PubMed Central Google Scholar
Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, Dennis J, Pirie A, Riggan MJ, Chornokur G, et al. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet. 2017;49(5):680–91.
Article CAS PubMed PubMed Central Google Scholar
Burgess S, Thompson SG. Avoiding bias from weak instruments in mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–64.
Bowden J, Del Greco MF, Minelli C, Zhao Q, Lawlor DA, Sheehan NA, Thompson J, Davey Smith G. Improving the accuracy of two-sample summary-data mendelian randomization: moving beyond the NOME assumption. Int J Epidemiol. 2019;48(3):728–42.
Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37(7):658–65.
Article PubMed PubMed Central Google Scholar
Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14.
Article PubMed PubMed Central Google Scholar
Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25.
Article PubMed PubMed Central Google Scholar
Burgess S, Thompson SG. Interpreting findings from mendelian randomization using the MR-Egger method. Eur J Epidemiol 2017, 32(5):377–89.
Jin Q, Ren F, Dai D, Sun N, Qian Y, Song P. The causality between intestinal flora and allergic diseases: insights from a bi-directional two-sample mendelian randomization analysis. Front Immunol. 2023;14:1121273.
Article CAS PubMed PubMed Central Google Scholar
Verbanck M, Chen CY, Neale B, Do R. Publisher correction: detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(8):1196.
Article CAS PubMed Google Scholar
Hemani G, Tilling K, Davey Smith G. Correction: orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 2017;13(12):e1007149.
Article PubMed PubMed Central Google Scholar
Benjamini Y, Hochberg Y. Controlling the false Discovery rate: a practical and powerful Approach to multiple testing. J Roy Stat Soc: Ser B (Methodol). 1995;57(1):289–300.
Hao X, Ren C, Zhou H, Li M, Zhang H, Liu X. Association between circulating immune cells and the risk of prostate cancer: a mendelian randomization study. Front Endocrinol (Lausanne) 2024, 15:1358416.
Zhang J, Wang P, Wang J, Wei X, Wang M. Unveiling intratumoral microbiota: an emerging force for colorectal cancer diagnosis and therapy. Pharmacol Res 2024:107185.
Cao B, Li Y, Lin M, Xu J, Li T, Fei X, et al. Integrated analysis of metabolomic and gut microbiota reveals idiosyncratic drug-induced liver injury resulting from the combined administration of bavachin and icariside II. Acupunct Herb Med. 2024;4(2):222–33. https://doi.org/10.1097/HM9.0000000000000099.
Garbas K, Zapała P, Zapała Ł, Radziszewski P. The role of microbial factors in prostate Cancer Development-An Up-to-date review. J Clin Med 2021, 10(20).
Li D, Sun T, Tong Y, Le J, Yao Q, Tao J, Liu H, Jiao W, Mei Y, Chen J, et al. Gut-microbiome-expressed 3β-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females. Cell Metab. 2023;35(4):685–e694685.
Article CAS PubMed Google Scholar
Chang CY, McDonnell DP. Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer. Clin Cancer Res. 2012;18(22):6089–95.
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