Biotransformation of diclofenac by Stenotrophomonas humi strain DIC_5 and toxicological examination of the resulting metabolites

Aissaoui S, Ouled-Haddar H, Sifour M, Harrouche K, Sghaier H (2017) Metabolic and co-metabolic transformation of diclofenac by Enterobacter hormaechei D15 isolated from activated sludge. Curr Microbiol 74:381–388

Article  PubMed  CAS  Google Scholar 

Altman R, Bosch B, Brune K, Patrignani P, Young C (2015) Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs 75:859–877

Article  PubMed  PubMed Central  CAS  Google Scholar 

Beek T, Weber FA, Bergmann A, Hickmann S, Ebert I, Hein A, Küster A (2016) Pharmaceuticals in the environment—global occurrences and perspectives. Environ Toxicol Chemis 35:823–835

Article  Google Scholar 

Benedek T, Pápai M, Gharieb K, Bedics A, Táncsics A, Tóth E, Daood H, Maróti G, Wirth R, Menashe O, Bóka K, Kriszt B (2022) Nocardioides carbamazepini sp. nov., an ibuprofen degrader isolated from a biofilm bacterial community enriched on carbamazepine. Syst Appl Microbiol 45:126339

Bessa VS, Moreira IS, Tiritan ME, Castro PML (2017) Enrichment of bacterial strains for the biodegradation of diclofenac and carbamazepine from activated sludge. Int Biodeterior Biodegrad 120:135–142

Article  CAS  Google Scholar 

Bio S, Nunes B (2020) Acute effects of diclofenac on zebrafish: indications of oxidative effects and damages at environmentally realistic levels of exposure. Environ Toxicol Pharmacol 78:103394

Article  PubMed  CAS  Google Scholar 

Boisseaux P, Noury P, Thomas H, Garric J (2017) Immune responses in the aquatic gastropod Lymnaea stagnalis under short-term exposure to pharmaceuticals of concern for immune systems: diclofenac, cyclophosphamide and cyclosporine A. Ecotoxicol Environ Saf 139:358–366

Article  PubMed  CAS  Google Scholar 

Brune K, Patrignani P (2015) New insights into the use of currently available non-steroidal anti-inflammatory drugs. J Pain Res 105:118

Google Scholar 

Carneiro RB, Gomes GM, Camargo FP, Zaiat M, Santos-Neto ÁJ (2024) Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation. Chemosphere 357:142006

Article  PubMed  CAS  Google Scholar 

Chabchoubi I, Bouchhima RA, Louhichi N, Baanannou A, Masmoudi S, Hentati O (2023) Short-term effects of various non-steroidal anti-inflammatory drugs (NSAIDs) on Danio rerio embryos. MethodsX 10:102215

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen JB, Gao HW, Zhang YL, Zhang Y, Zhou XF, Li CQ, Gao HP (2014) Developmental toxicity of diclofenac and elucidation of gene regulation in zebrafish (Danio rerio). Sci Rep 4:4841

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chiron S, Gomez E, Fenet H (2010) Nitration processes of acetaminophen in nitrifying activated sludge. Environ Sci Technol 44:284–289

Article  PubMed  CAS  Google Scholar 

Csenki Z, Garai E, Risa A, Cserháti M, Bakos K, Márton D, Bokor Z, Kriszt B, Urbányi B (2019) Biological evaluation of microbial toxin degradation by microinjected zebrafish (Danio rerio) embryos. Chemosphere 227:151–161

Article  PubMed  CAS  Google Scholar 

Csenki Z, Risa A, Sárkány D, Garai E, Bata-Vidács I, Baka E, Szekeres A, Varga M, Ács A, Griffitts J, Bakos K, Bock I, Szabó I, Kriszt B, Urbányi B, Kukolya, J (2022) Comparison evaluation of the biological effects of sterigmatocystin and aflatoxin B1 utilizing SOS-chromotest and a novel zebrafish (Danio rerio) embryo microinjection method Toxins 14:252

Di Lorenzo T, Cifoni M, Baratti M, Pieraccini G, Di Marzio WD, Galassi DMP (2021) Four scenarios of environmental risk of diclofenac in European groundwater ecosystems. Environ Pollut 287:117315

Article  PubMed  Google Scholar 

Domaradzka D, Guzik U, Hupert-Kocurek K, Wojcieszyńska D (2016) Toxicity of diclofenac and its biotransformation by Raoultella sp. DD4. Polish J Environ Stud 25:2211–2216

Article  CAS  Google Scholar 

Eniola JO, Kumar R, Barakat MA, Rashid J (2022) A review on conventional and advanced hybrid technologies for pharmaceutical wastewater treatment. J Clean Prod 356:131826

Article  CAS  Google Scholar 

Espinoza LAT, Neamţu M, Frimmel FH (2007) The effect of nitrate, Fe (III) and bicarbonate on the degradation of bisphenol A by simulated solar UV-irradiation Water Res 41:479–4487

Evgenidou EN, Konstantinou IK, Lambropoulou DA (2015) Occurrence and removal of transformation products of PPCPs and illicit drugs in wastewaters: a review. Sci Total Environ 505:905–926

Article  PubMed  CAS  Google Scholar 

Farré M, Ferrer I, Ginebreda A, Figueras M, Olivella L, Tirapu L, Vilanova M, Barcelo D (2001) Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. J Chromatogr A 938:187–197

Article  PubMed  Google Scholar 

Ferrari B, Paxeus N, Lo Giudice R, Pollio A, Garric J (2003) Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine clofibric acid and diclofenac. Ecotoxicol Environ Saf 55:359–370

Article  PubMed  CAS  Google Scholar 

Fu Q, Fedrizzi D, Kosfeld V, Schlechtriem C, Ganz V, Derrer S, Rentsch D, Hollender J (2020) Biotransformation changes bioaccumulation and toxicity of diclofenac in aquatic organisms. Environ Sci and Technol 54:4400–4408

Article  CAS  Google Scholar 

Garai E, Risa A, Varga E, Cserháti M, Kriszt B, Urbányi B, Csenki Z (2020) Qualifying the T-2 toxin-degrading properties of seven microbes with zebrafish embryo microinjection method. Toxins 12:460

Article  PubMed  PubMed Central  CAS  Google Scholar 

Garai E, Risa A, Varga E, Cserháti M, Kriszt B, Urbányi B, Csenki Z (2021) Evaluation of the multimycotoxin-degrading efficiency of Rhodococcus erythropolis NI1 strain with the three-step zebrafish microinjection method. Int J Mol Sci 22:724

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gyuris R, Szabó Á, László AM, Gutermuth Á, Sörös C (2024) An evaluation of insecticidal trunk injections for the control of the European cherry fruit fly Rhagoletis cerasi L. (Diptera: Tephritidae). Horticulturae 10:278

Hallare AV, Köhler HR, Triebskorn R (2004) Developmental toxicity and stress protein responses in zebrafish embryos after exposure to diclofenac and its solvent, DMSO. Chemosphere 56:659–666

Article  PubMed  CAS  Google Scholar 

Hanif H, Waseem A, Kali S, Qureshi NA, Majid M, Iqbal M, Ur-Rehman T, Tahir M, Yousaf S, Iqbal MM, Khan AI, Zafar MI (2020) Environmental risk assessment of diclofenac residues in surface waters and wastewater: a hidden global threat to aquatic ecosystem. Environ Monit Assess 192:1–12

Article  Google Scholar 

Heylen K, Vanparys B, Peirsegaele F, Lebbe L, De Vos P (2007) Stenotrophomonas terrae sp. nov. and Stenotrophomonas humi sp. nov., two nitrate-reducing bacteria isolated from soil. Int J Syst Evol Microbiol 57:2056–2061

Article  PubMed  CAS  Google Scholar 

Khan HK, Rehman MYA, Malik RN (2020) Fate and toxicity of pharmaceuticals in water environment: an insight on their occurrence in South Asia. J Environ Manag 271:111030

Article  CAS  Google Scholar 

Khan AH, Aziz HA, Khan NA, Hasan MA, Ahmed S, Farooqi IH, Dhingra A, Vambol V, Changani F, Yousefi M, Islam S, Mozaffari N, Mahtab MS (2021) Impact, disease outbreak and the eco-hazards associated with pharmaceutical residues: a critical review. Intern J Environ Sci Technol 1:12

Google Scholar 

Lamfalusy T, Soros C (2021) Development of analytical protocol for the investigation of transformation products of pre-harvest fungicides in fruits using LC-MS/MS methods. Food Addit Contam Part A 38:1206–1217

Article  CAS  Google Scholar 

Liu Z, Yang C, Qiao C (2007) Biodegradation of p-nitrophenol and 4-chlorophenol by Stenotrophomonas sp. FEMS Microbiol Let 277:150–156

Article  CAS  Google Scholar 

Matejczyk M, Ofman P, Dąbrowska K, Świsłocka R, Lewandowski W (2020) The study of biological activity of transformation products of diclofenac and its interaction with chlorogenic acid. J Environ Sci 91:128–141

Article  CAS  Google Scholar 

Moreira IS, Bessa VS, Murgolo S, Piccirillo C, Mascolo G, Castro PML (2018) Biodegradation of diclofenac by the bacterial strain Labrys portucalensis F11. Ecotoxicol Environl Saf 52:04–113

Google Scholar 

Mytilinaios I, Salih M, Schofield HK, Lambert RJ (2012) Growth curve prediction from optical density data. Int J Food Microbiol 154:169–176

Article  PubMed  CAS  Google Scholar 

Nassef M, Kim SG, Seki M, Kang IJ, Hano T, Shimasaki Y, Oshima Y (2010) In ovo nanoinjection of triclosan, diclofenac and carbamazepine affects embryonic development of medaka fish (Oryzias latipes). Chemosphere 79:966–973

Article  PubMed  CAS  Google Scholar

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