Labaki WW, Rosenberg SR (2020) Chronic obstructive pulmonary disease. Ann Intern Med. https://doi.org/10.7326/AITC202008040

Article  PubMed  Google Scholar 

Murgia X, Kany AM, Herr C, Ho DK et al (2020) Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection. Sci Rep. https://doi.org/10.1038/s41598-020-73459-5

Article  PubMed  PubMed Central  Google Scholar 

Malhotra S, Hayes D Jr, Wozniak DJ (2019) Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface. Rev Clin Microbiol Rev. https://doi.org/10.1128/CMR.00138-18

Article  PubMed  Google Scholar 

Pang Z, Raudonis R, Glick BR et al (2019) Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. Biotechnol Adv. https://doi.org/10.1016/j.biotechadv.2018.11.013

Article  PubMed  Google Scholar 

Subedi D, Vijay AK, Kohli GS, Rice SA et al (2018) Comparative genomics of clinical strains of Pseudomonas aeruginosa strains isolated from different geographic sites. Sci Rep. https://doi.org/10.1038/s41598-018-34020-7

Article  PubMed  PubMed Central  Google Scholar 

Lutz L, Leão RS, Ferreira AG et al (2013) Hypermutable Pseudomonas aeruginosa in cystic fibrosis patients from two Brazilian cities. Am Soc Microbio. https://doi.org/10.1128/JCM.02638-12

Article  Google Scholar 

Irvine S, Bunk B, Bayes HK et al (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microb Genom. https://doi.org/10.1099/mgen.0.000262

Article  PubMed  PubMed Central  Google Scholar 

Rees VE, Deveson Lucas DS, López-Causapé C, Huang Y et al (2019) Characterization of hypermutator Pseudomonas aeruginosa isolates from patients with cystic fibrosis in Australia. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.02538-18

Article  PubMed  PubMed Central  Google Scholar 

Vidaillac C, Yong VFL, Aschtgen MS, Qu J et al (2020) Sex steroids induce membrane stress responses and virulence properties in Pseudomonas aeruginosa. MBio. https://doi.org/10.1128/mBio.01774-20

Article  PubMed  PubMed Central  Google Scholar 

Cross AR, Raghuram V, Wang Z, Dey D et al (2020) Overproduction of the AlgT sigma factor is lethal to mucoid Pseudomonas aeruginosa. J Bacteriol. https://doi.org/10.1128/JB.00445-20

Article  PubMed  PubMed Central  Google Scholar 

Oliver A, Canton R, Campo P et al (2000) High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 288:1251–1254

Article  CAS  PubMed  Google Scholar 

Bilal H, Bergen PJ, Tait JR et al (2020) Clinically relevant epithelial lining fluid concentrations of meropenem with ciprofloxacin provide synergistic killing and resistance suppression of hypermutable Pseudomonas aeruginosa in a dynamic biofilm model. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00469-20

Article  PubMed  PubMed Central  Google Scholar 

Mena A, Maciá MD, Borrell N et al (2007) Inactivation of the mismatch repair system in Pseudomonas aeruginosa attenuates virulence but favors persistence of oropharyngeal colonization in cystic fibrosis mice. J Bacteriol 189:3665–3668. https://doi.org/10.1128/JB.00120-07

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khil PP, Dulanto A, Ho J et al (2019) Dynamic emergence of mismatch repair deficiency facilitates rapid evolution of ceftazidime-avibactam resistance in Pseudomonas aeruginosa acute infection. MBio. https://doi.org/10.1128/Mbio.01822-19

Article  PubMed  PubMed Central  Google Scholar 

Sabra W, Haddad AM, Zeng A-P (2014) Comparative physiological study of the wild type and the small colony variant of Pseudomonas aeruginosa 20265 under controlled growth conditions. World J Microbiol Biotechnol. https://doi.org/10.1007/s11274-013-1521-z

Article  PubMed  Google Scholar 

Malone JG (2015) Role of small colony variants in persistence of Pseudomonas aeruginosa infections in cystic fibrosis lungs. Infect Drug Resist. https://doi.org/10.2147/IDR.S68214

Article  PubMed  PubMed Central  Google Scholar 

Miller JM, Binnicker MJ, Campbell S et al (2018) A guide to utilization of the microbiology laboratory for diagnosis of infectious dis-eases: 2018 update by the infectious diseases society of America and the American society for microbiology. Clin Infect Dis. https://doi.org/10.1093/cid/ciy381

Article  PubMed  PubMed Central  Google Scholar 

BRASIL. Agência Nacional de Vigilância Sanitária. Microbiologia Clínica para o Controle de Infecção Relacionada à Assistência à Saúde. Módulo 4: Procedimentos Laboratoriais: da requisição do exame à análise microbiológica e laudo final (2013) Agência Nacional de Vigilância Sanitária (Anvisa). Brasília. https://www.saude.go.gov.br/images/imagens_migradas/upload/arquivos/2017-02/modulo-4---procedimentos-laboratoriais---da-requisicao-do-exame-a-analise-microbiologica-e-laudo-final.pdf

Clinical and Laboratory Standards Intitute (CLSIa) Standards, Performance Testing, Antimicrobial Susceptibility. CLSI document M100. Wayne, P.A., 2020.

Clinical and Laboratory Standards Intitute (CLSIb) Performance Standards for Antimicrobial Disk Susceptibility Tests. CLSI document M02. Wayne, P.A., 2020.

Clinical and Laboratory Standards Intitute (CLSIc) Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. CLSI document M07. Wayne, P.A., 2020.

Magiorakos AP, Srinivasan A, Carey RB et al (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. https://doi.org/10.1111/j.1469-0691.2011.03570.x

Article  PubMed  Google Scholar 

Ciofu O, Riis B, Pressler T et al (2005) Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother 49:2276–2282. https://doi.org/10.1128/AAC.49.6.2276-2282.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maciá MD et al (2004) Detection and Susceptibility testing of hypermutable Pseudomonas aeruginosa strains with the etest and disk diffusion. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.48.7.2665-2672.2004

Article  PubMed  PubMed Central  Google Scholar 

Bankevich A, Nurk S, Antipov D et al (2012) SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol. https://doi.org/10.1089/cmb.2012.0021

Article  PubMed  PubMed Central  Google Scholar 

Pritchard L, Glover RH, Humphris S et al (2016) Genomics and taxonomy in diagnostics for food security: soft-rotting enterobacterial plant pathogens. Anal Methods. https://doi.org/10.1039/C5AY02550H

Article  Google Scholar 

Potron A, Poirel L, Nordmann P (2015) Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: mechanisms and epidemiology. Int J Antimicrob Agents. https://doi.org/10.1016/j.ijantimicag.2015.03.001

Article  PubMed  Google Scholar 

Rossi E, La Rosa R, Bartell JA et al (2020) Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis. Nat Rev Microbio. https://doi.org/10.1038/s41579-020-00477-5

Article  Google Scholar 

Ferreira AG, Leão RS, Carvalho-Assef AP et al (2010) Influence of biofilm formation in the susceptibility of Pseudomonas aeruginosa from Brazilian patients with cystic fibrosis. APMIS. https://doi.org/10.1111/j.1600-0463.2010.02636.x

Article  PubMed  Google Scholar 

Bonyadi P, Saleh NT, Dehghani M et al (2022) Prevalence of antibiotic resistance of Pseudomonas aeruginosa in cystic fibrosis infection: a systematic review and meta-analysis. Microb Pathog. https://doi.org/10.1016/j.micpath.2022.105461

Article  PubMed  Google Scholar 

Reynolds D, Kollef M (2021) The epidemiology and pathogenesis and treatment of Pseudomonas aeruginosa infections: an update. Drugs. https://doi.org/10.1007/s40265-021-01635-6

Article  PubMed  PubMed Central  Google Scholar 

Savinova T, Bocharova Y, Mayanskiy N, Chebotar I (2022) Genetic determinants of virulence and antibiotic resistance are common for Pseudomonas aeruginosa ST235 isolates from cystic fibrosis patients from various geographical regions. Diagn Microbiol Infect Dis. https://doi.org/10.1016/j.diagmicrobio.2021.115596

Article  PubMed  Google Scholar 

Almeida MM, Marques EA, Leao RS et al (2021) Ca