Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node

Grasso C, Pierie C, Mebius RE, van Baarsen LGM. Lymph node stromal cells: subsets and functions in health and disease. Trends Immunol. 2021;42:920–36.

Article  CAS  PubMed  Google Scholar 

Rodda LB, Lu E, Bennett ML, Sokol CL, Wang X, Luther SA, et al. Single-cell RNA sequencing of lymph node stromal cells reveals niche-associated heterogeneity. Immunity. 2018;48:1014–28.e6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takeda A, Salmi M, Jalkanen S. Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system. Trends Immunol. 2023;44:72–86.

Article  CAS  PubMed  Google Scholar 

Hons M, Sixt M. The lymph node filter revealed. Nat Immunol. 2015;16:338–40.

Article  CAS  PubMed  Google Scholar 

Bogoslowski A, Kubes P. Lymph Nodes: The Unrecognized Barrier against Pathogens. ACS Infect Dis. 2018;4:1158–61.

Article  CAS  PubMed  Google Scholar 

Cruz de Casas P, Knöpper K, Dey Sarkar R, Kastenmüller W Same yet different - how lymph node heterogeneity affects immune responses. Nat Rev Immunol. 2023.

Rantakari P, Auvinen K, Jäppinen N, Kapraali M, Valtonen J, Karikoski M, et al. The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. Nat Immunol. 2015;16:386–96.

Article  CAS  PubMed  Google Scholar 

Roozendaal R, Mempel TR, Pitcher LA, Gonzalez SF, Verschoor A, Mebius RE, et al. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity. 2009;30:264–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, et al. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. 2016;5.

Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007;450:110–4.

Article  CAS  PubMed  Google Scholar 

Sigal LJ Chapter Six - The Pathogenesis and Immunobiology of Mousepox. In: Alt FW, editor. Advances in Immunology. 129: Academic Press; 2016. 251-76.

Esteban DJ, Buller RML. Ectromelia virus: the causative agent of mousepox. J Gen Virol. 2005;86:2645–59.

Article  CAS  PubMed  Google Scholar 

Buller RM, Palumbo GJ. Poxvirus pathogenesis. Microbiol Rev. 1991;55:80–122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosen JB, Arciuolo RJ, Pathela P, Boyer CB, Baumgartner J, Latash J, et al. JYNNEOS effectiveness as post-exposure prophylaxis against mpox: Challenges using real-world outbreak data. Vaccine. 2024;42:548–55.

Article  CAS  PubMed  Google Scholar 

Marchal J. Infectious ectromelia. A hitherto undescribed virus disease of mice. J Pathol Bacteriol. 1930;33:713–28.

Article  Google Scholar 

McCollum AM, Damon IK. Human monkeypox. Clin Infect Dis. 2014;58:260–7.

Article  PubMed  Google Scholar 

Laurenson-Schafer H, Sklenovská N, Hoxha A, Kerr SM, Ndumbi P, Fitzner J, et al. Description of the first global outbreak of mpox: an analysis of global surveillance data. Lancet Glob Health. 2023;11:e1012–e23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suthar MS, Diamond MS, Gale M Jr. West Nile virus infection and immunity. Nat Rev Microbiol. 2013;11:115–28.

Article  CAS  PubMed  Google Scholar 

Reynoso GV, Gordon DN, Kalia A, Aguilar CC, Malo CS, Aleshnick M, et al. Zika virus spreads through infection of lymph node-resident macrophages. Cell Rep. 2023;42:112126.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calderón-Peláez M-A, Velandia-Romero ML, Bastidas-Legarda LY, Beltrán EO, Camacho-Ortega SJ, Castellanos JE Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease. Frontiers in Microbiology. 2019;10.

Nekoua MP, Alidjinou EK, Hober D. Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus. Nat Rev Endocrinol. 2022;18:503–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minor PD An Introduction to Poliovirus: Pathogenesis, Vaccination, and the Endgame for Global Eradication. In: Martín J, editor. Poliovirus: Methods and Protocols. New York, NY: Springer New York; 2016. 1-10.

Bodian D Mechanisms of infection with polioviruses. Cellular Biology Nucleic Acids and Viruses,(0 V St Whitelock, editor), New York, New York Academy of Sciences. 1957.

Racaniello VR. One hundred years of poliovirus pathogenesis. Virology. 2006;344:9–16.

Article  CAS  PubMed  Google Scholar 

Ida-Hosonuma M, Iwasaki T, Yoshikawa T, Nagata N, Sato Y, Sata T, et al. The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J Virol. 2005;79:4460–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang M, Lanier LL, Sigal LJ. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLoS Pathog. 2008;4:e30.

Article  PubMed  PubMed Central  Google Scholar 

Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ. CD94 is essential for NK cell-mediated resistance to a lethal viral disease. Immunity. 2011;34:579–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang M, Roscoe F, Sigal LJ. Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking. J Exp Med. 2010;207:2369–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Melo-Silva CR, Alves-Peixoto P, Heath N, Tang L, Montoya B, Knudson CJ, et al. Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells. PLoS Pathog. 2021;17:e1009593.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong E, Montoya B, Stotesbury C, Ferez M, Xu RH, Sigal LJ. Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node. Cell Rep. 2019;29:3047–59.e3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong E, Xu RH, Rubio D, Lev A, Stotesbury C, Fang M, et al. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node. Cell Rep. 2018;24:142–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, et al. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. Immunity. 2015;43:1148–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frederico B, Chao B, Lawler C, May JS, Stevenson PG. Subcapsular sinus macrophages limit acute gammaherpesvirus dissemination. J Gen Virol. 2015;96:2314–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature. 2010;465:1079–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif