Differential Impact of VNTR Polymorphism in the CBS Gene on Gastric and Breast Cancers Risk

Lauinger L, Kaiser P. Sensing and signaling of methionine metabolism. Metabolites. 2021;11(2): 83. https://doi.org/10.3390/metabo11020083.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanderson SM, Gao X, Dai Z, Locasale JW. Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nat Rev Cancer. 2019;19(11):625–37. https://doi.org/10.1038/s41568-019-0187-8.

Article  CAS  PubMed  Google Scholar 

Sbodio JI, Snyder SH, Paul BD. Regulators of the transsulfuration pathway. Br J Pharmacol. 2019;176(4):583. https://doi.org/10.1038/s41568-019-0187-8.

Article  CAS  PubMed  Google Scholar 

Zuhra K, Augsburger F, Majtan T, Szabo C. Cystathionine-β-synthase: molecular regulation and pharmacological inhibition. Biomolecules. 2020;10(5): 697. https://doi.org/10.3390/biom10050697.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang HF, Geltink RI, Parker SJ, Sorensen PH. Transsulfuration, minor player or crucial for cysteine homeostasis in cancer. Trends Cell Biol. 2022;32(9):800–14. https://doi.org/10.1016/j.tcb.2022.02.009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weber R, Birsoy K. The transsulfuration pathway makes, the Tumor takes. Cell Metabol. 2019;30(5):845–6. https://doi.org/10.1016/j.cmet.2019.10.009.

Article  CAS  Google Scholar 

Zhu H, Blake S, Chan KT, Pearson RB, Kang J. Cystathionine β-synthase in physiology and cancer. Biomed Res Int. 2018. https://doi.org/10.1155/2018/3205125.

Article  PubMed  PubMed Central  Google Scholar 

Wang RH, Chu YH, Lin KT. The hidden role of hydrogen sulfide metabolism in cancer. Int J Mol Sci. 2021;22(12): 6562. https://doi.org/10.3390/ijms22126562.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khattak S, Rauf MA, Khan NH, Zhang QQ, Chen HJ, Muhammad P, et al. Hydrogen sulfide biology and its role in cancer. Molecules. 2022;27(11): 3389. https://doi.org/10.3390/molecules27113389.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ascençao K, Szabo C. Emerging roles of cystathionine β-synthase in various forms of cancer. Redox Biol. 2022;53: 102331. https://doi.org/10.1016/j.redox.2022.102331.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Münke M, Kraus JP, Ohura T, Francke U. The gene for cystathionine beta-synthase (CBS) maps to the subtelomeric region on human chromosome 21q and to proximal mouse chromosome 17. Am J Hum Genet. 1988;42(4):550.

PubMed  PubMed Central  Google Scholar 

Kraus JP, Oliveriusova J, Sokolová J, Kraus E, Vlček Č́, de Franchis R, et al. The human cystathionine β-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms. Genomics. 1998;52(3):312–24. https://doi.org/10.1006/geno.1998.5437.

Article  CAS  PubMed  Google Scholar 

Bao L, Vlček Č, Pačes V, Kraus JP. Identification and tissue distribution of human cystathionine β-synthase mRNA isoforms. Arch Biochem Biophys. 1998;350(1):95–103. https://doi.org/10.1006/abbi.1997.0486.

Article  CAS  PubMed  Google Scholar 

Eslami Rasekh M, Hernández Y, Drinan SD, Fuxman Bass JI, Benson G. Genome-wide characterization of human minisatellite VNTRs: population-specific alleles and gene expression differences. Nucleic Acids Res. 2021;49(8):4308–24. https://doi.org/10.1093/nar/gkab224.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang F, Hanson NQ, Schwichtenberg K, Tsai MY. Variable number tandem repeat in exon/intron border of the cystathionine beta-synthase gene: a single nucleotide substitution in the second repeat prevents multiple alternate splicing. Am J Med Genet. 2000;95(4):385–90. https://doi.org/10.1002/1096-8628(20001211)95:4%3c385::aid-ajmg16%3e3.0.co;2-v.

Article  CAS  PubMed  Google Scholar 

Lievers K, Kluijtmans L, Heil S, Boers G, Verhoef P, van Oppenraay-Emmerzaal D, et al. A 31 bp VNTR in the cystathionine β-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels. Eur J Hum Genet. 2001;9(8):583–9. https://doi.org/10.1038/sj.ejhg.5200679.

Article  CAS  PubMed  Google Scholar 

Sen S, Kawahara B, Gupta D, Tsai R, Khachatryan M, Roy-Chowdhuri S, et al. Role of cystathionine β-synthase in human breast cancer. Free Radic Biol Med. 2015;86:228–38. https://doi.org/10.1016/j.freeradbiomed.2015.05.024.

Article  CAS  PubMed  Google Scholar 

Ramírez-Bello J. Role of genetic variability in mendelian and multifactorial diseases. Gac Med Mex. 2019;155(5):463–70. https://doi.org/10.24875/GMM.M20000333.

Article  PubMed  Google Scholar 

Gan YY, Chen CF. Novel alleles of 31-bp VNTR polymorphism in the human cystathionine β-synthase (CBS) gene were detected in healthy asians. J Genet. 2010. https://doi.org/10.1007/s12041-010-0063-5.

Article  PubMed  Google Scholar 

Senemar S, Doroudchi M, Pezeshki AM, Bazrgar M, Torab-Jahromi A, Ghaderi A. Frequency of cystathionine β-synthase 844INS68 polymorphism in Southern Iran. Mol Biol Rep. 2009;36:353–6. https://doi.org/10.1007/s11033-007-9186-z.

Article  CAS  PubMed  Google Scholar 

Sponholz C, Kramer M, Schöneweck F, Menzel U, Inanloo Rahatloo K, Giamarellos-Bourboulis EJ, et al. Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis. Eur J Hum Genet. 2016;24(7):1041–8.

Article  CAS  PubMed  Google Scholar 

Salemi M, Barone C, Romano C, Salluzzo MG, Giambirtone M, Morale MC, et al. A peculiar VNTR in the cystathionine β-synthase gene is a risk factor for down syndrome. Cell Mol Biol. 2015;61(5):49–51. https://doi.org/10.1038/ejhg.2015.231.

Article  CAS  PubMed  Google Scholar 

Beyer K, Lao JI, Latorre P, Ariza A. Age at onset: an essential variable for the definition of genetic risk factors for sporadic Alzheimer’s disease. Ann N Y Acad Sci. 2005;1057(1):260–78. https://doi.org/10.1196/annals.1322.021.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif