Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. Global burden of cardiovascular diseases and risk factors, 1990–2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020;76(25):2982–3021. https://doi.org/10.1016/j.jacc.2020.11.010.

Deora S, Kumar T, Ramalingam R, Nanjappa MC. Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India. Cardiovasc Diagn Ther. 2016;6(3):193–8. https://doi.org/10.21037/cdt.2016.03.05.

Article  PubMed Central  PubMed  Google Scholar 

Bhatt DL, Lopes RD, Harrington RA. Diagnosis and treatment of acute coronary syndromes: a review. JAMA. 2022;327(7):662–75. https://doi.org/10.1001/jama.2022.0358.

Article  PubMed  Google Scholar 

Wang XY, Zhang F, Zhang C, Zheng LR, Yang J. The biomarkers for acute myocardial infarction and heart failure. Biomed Res Int. 2020;2020:2018035. https://doi.org/10.1155/2020/2018035.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Abe T, Samuel I, Eferoro E, Samuel AO, Monday IT, Olunu E, et al. The diagnostic challenges associated with type 2 myocardial infarction. Int J Appl Basic Med Res. 2021;11(3):131–8. https://doi.org/10.4103/ijabmr.IJABMR_210_20.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Xu S, Jiang J, Zhang Y, Chen T, Zhu M, Fang C, et al. Discovery of potential plasma protein biomarkers for acute myocardial infarction via proteomics. J Thorac Dis. 2019;11(9):3962–72. https://doi.org/10.21037/jtd.2019.08.100.

Article  PubMed Central  PubMed  Google Scholar 

Wu Y, Pan N, An Y, Xu M, Tan L, Zhang L. Diagnostic and prognostic biomarkers for myocardial infarction. Front Cardiovasc Med. 2021;7: 617277. https://doi.org/10.3389/fcvm.2020.617277.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Tanaka K, Takeda S, Mitsuoka K, Oda T, Kimura-Sakiyama C, Maéda Y, et al. Structural basis for cofilin binding and actin filament disassembly. Nat Commun. 2018;9(1):1860. https://doi.org/10.1038/s41467-018-04290-w.

Article  ADS  CAS  PubMed Central  PubMed  Google Scholar 

Maciver SK, Hussey PJ. The ADF/cofilin family: actin-remodeling proteins. Genome Biol. 2002;3(5):3007.

Article  Google Scholar 

Ehler E. Actin-associated proteins and cardiomyopathy-the “unknown” beyond troponin and tropomyosin. Biophys Rev. 2018;10(4):1121–8. https://doi.org/10.1007/s12551-018-0428-1.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Kanellos G, Zhou J, Patel H, Radgway RA, Huels D, Gurniak CB, et al. ADF and cofilin1 control actin stress fibers, nuclear integrity, and cell survival. Cell Rep. 2015;13(9):1949–64. https://doi.org/10.1016/j.celrep.2015.10.056.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Blanchoin L, Boujemaa-Paterski R, Sykes C, Plastino J. Actine dynamics, architecture, and mechanics in cell motility. Physiol Rev. 2014;94(1):235–63. https://doi.org/10.1152/physrev.00018.2013.

Article  CAS  PubMed  Google Scholar 

Kremneva E, Makkonen MH, Skwarek-Maruszewska A, Gateva G, Michelot A, Dominguez R, et al. Cofilin-2 controls actin filament length in muscle sarcomeres. Dev cell. 2014;31(2):215–26. https://doi.org/10.1016/j.devcel.2014.09.002.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Mohri K, Suzuki-Toyota F, Obinata T, Sato N. Chimeric mice with deletion of Cfl2 that encodes muscle-type cofilin (MCF or Cofilin-2) results in defects of striated muscles, both skeletal and cardiac muscles. Zoolog Sci. 2019;36(2):112–9. https://doi.org/10.2108/zs180151.

Article  CAS  PubMed  Google Scholar 

Subramanian K, Gianni D, Balla C, Assenza GE, Joshi M, Semigran MJ, et al. Cofilin-2 phosphorylation and sequestration in myocardial aggregates: novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2015;65(12):1199–214. https://doi.org/10.1016/j.jacc.2015.01.031.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Chatzifrangkeskou M, Yadin D, Marais T, Chardonnet S, Cohen-Tannoudji M, Mougenot N, et al. Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation. Hum Mol Genet. 2018;27(17):3060–78. https://doi.org/10.1093/hmg/ddy215.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Nguyen K, Chau VQ, Mauro AG, Durrant D, Toldo S, Abbate A, et al. Hydrogen sulfide therapy suppresses cofilin-2 and attenuates ischemic heart failure in a mouse model of myocardial infarction. J Cardiovasc Pharmacol Ther. 2020;25(5):472–83. https://doi.org/10.1177/1074248420923542.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Wang L, Buckley AF, Spurney RF. Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). Sci Rep. 2018;8(1):12286. https://doi.org/10.1038/s41598-018-30115-3.

Article  ADS  CAS  PubMed Central  PubMed  Google Scholar 

Bamburg JR, Minamide LS, Wiggan O, Tahtamouni LH, Kuhn TB. Cofilin and actin dynamics: multiple modes of regulation and their impacts in neuronal development and degeneration. Cells. 2021;10(10):2726. https://doi.org/10.3390/cells10102726.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Sun Y, Liang L, Dong M, Li C, Liu Z, Gao H. Cofilin 2 in serum as a novel biomarker for Alzheimer’s Disease in Han Chinese. Front Aging Neurosci. 2019;11:214. https://doi.org/10.3389/fnagi.2019.00214.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Xu J, Huang Y, Zhao J, Wu L, Qi Q, Liu Y, et al. Cofilin: a promising protein implicated in cancer metastasis and apoptosis. Front Cell Dev Biol. 2021;9: 599065. https://doi.org/10.3389/fcell.2021.599065.

Article  PubMed Central  PubMed  Google Scholar 

Backus BE, Six AJ, Kelder JH, Gibler WB, Moll FL, Doevendans PA. Risk scores for patients with chest pain: evaluation in the emergency department. Curr Cardiol Rev. 2011;7(1):2–8. https://doi.org/10.2174/157340311795677662.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Liu N, Ng JC, Ting CE, Sakamoto JT, Ho AF, Koh ZX, et al. Clinical scores for risk stratification of chest pain patients in the emergency department: an updated systemic review. J Emerg Crit Care Med. 2018;2:16. https://doi.org/10.21037/jeccm.2018.01.10.

Article  Google Scholar 

Hajian-Tilaki K. Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Caspian J Intern Med. 2013;4(2):627–35.

PubMed Central  PubMed  Google Scholar 

Baumann AAW, Mishra A, Worthley MI, Nelson AJ, Psaltis PJ. Management of multivessel coronary artery disease in patients with non-ST-elevation myocardial infarction: a complex path to precision medicine. Ther Adv Chronic Dis. 2020;11:2040622320938527. https://doi.org/10.1177/2040622320938527.

Article  PubMed Central  PubMed  Google Scholar 

Baumann AA, Tavella R, Air TM, Mishra A, Montarello NJ, Arstall M, et al. Prevalence and real-world management of NSTEMI with multivessel disease. Cardiovasc Diagn Ther. 2022;12(1):1–11. https://doi.org/10.21037/cdt-21-518.

Article  PubMed Central  PubMed  Google Scholar 

Sharma YP, Santosh Vemuri K, Bootla D, Kanabar K, Pruthvi CR, Kaur N, et al. Epidemiological profile, management and outcomes of patients with acute coronary syndrome: single centre experience from a tertiary care hospital in North India. Indian Heart J. 2021;73(2):174–9. https://doi.org/10.1016/j.ihj.2020.11.149.

Article  PubMed Central  PubMed  Google Scholar 

Wang D, Enck J, Howell BW, Olson EC. Ethanol exposure transiently elevates but persistently inhibits tyrosine kinase activity and impairs the growth of the nascent apical dendrite. Mol Neurobiol. 2019;56(8):5749–62. https://doi.org/10.1007/s12035-019-1473-x.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Limatola N, Vasilev F, Santella L, Chun JT. Nicotine induces polyspermy in sea urchin eggs through a non-cholinergic pathway modulating actin dynamics. Cells. 2019;9(1):63. https://doi.org/10.3390/cells9010063.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Babes EE, Bustea C, Behl T, Abdel-Daim MM, Nechifor AC, Stoicescu M, et al. Acute coronary syndromes in diabetic patients, outcome, revascularization, and antithrombotic therapy. Biomed Pharmacother. 2022;148: 112772. https://doi.org/10.1016/j.biopha.2022.112772.

Article  CAS  PubMed  Google Scholar 

Dhungana SP, Mahato AK, Ghimire R, Shreewastav RK. Prevalence of dyslipidemia in patients with acute coronary syndrome admitted at tertiary care hospital in Nepal: A descriptive cross-sectional study. JNMA J Nepal Med Assoc. 2020;58(224):204–208. https://doi.org/10.31729/jnma.4765.

Hien TT, Turczyńska KM, Dahan D, Ekman M, Grossi M, Sjögren J, et al. Elevated glucose levels promote contractile and cytoskeletal gene expression in vascular smooth muscle via Rho/Protein kinase C and actin polymerization. J Biol Chem. 2016;291(7):3552–68. https://doi.org/10.1074/jbc.M115.654384.

Article  CAS  PubMed  Google Scholar 

Hansson B, Morén B, Fryklund C, Vliex L, Wasserstrom S, Albinsson S, et al. Adipose cell size changes are associated with a drastic actin remodeling. Sci Rep. 2019;9:12941.