Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway

Hussey GS, Dziki JL, Badylak SF. Extracellular matrix-based materials for regenerative medicine. Nat Rev Mater. 2018;3:159–73.

Article  CAS  Google Scholar 

Sutherland TE, Dyer DP, Allen JE. The extracellular matrix and the immune system. A mutually dependent relationship. Science. 2023;379:eabp8964.

Article  CAS  PubMed  Google Scholar 

Saraswathibhatla A, Indana D, Chaudhuri O. Cell-extracellular matrix mechanotransduction in 3D. Nat Rev Mol Cell Biol. 2023;24:495–516.

Article  CAS  PubMed  Google Scholar 

Yang B, Yang X, Luo X, Chen G, Chen J, Huo F, Zhu Z, Tian Y, Guo W, Tian W. DFCs/TDM based artificial bio-root to obtain long-term functional root regeneration in non-human primate. Chem Eng J. 2023;451:138738.

Article  CAS  Google Scholar 

Tajima K, Yagi H, Morisaku T, Nishi K, Kushige H, Kojima H, Higashi H, Kuroda K, Kitago M, Adachi S, et al. An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model. NPJ Regen Med. 2022;7:18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maelene LW, Janelle LW, Natalia V, Leigh GG. In vivo xenogeneic scaffold fate is determined by residual antigenicity and extracellular matrix preservation. Biomaterials. 2016. https://doi.org/10.1016/j.biomaterials.2016.03.024.

Article  Google Scholar 

Li H, Ma B, Yang H, Qiao J, Tian W, Yu R. Xenogeneic dentin matrix as a scaffold for biomineralization and induced odontogenesis. Biomed Mater. 2021;16: 045020.

Article  CAS  Google Scholar 

Li H, Sun J, Li J, Yang H, Luo X, Chen J, Xie L, Huo F, Zhu T, Guo W, Tian W. Xenogeneic bio-root prompts the constructive process characterized by macrophage phenotype polarization in rodents and nonhuman primates. Adv Healthc Mater. 2017;6:1601112.

Article  Google Scholar 

Li H, Sun J, Yang H, Han X, Luo X, Liao L, Yang B, Zhu T, Huo F, Guo W, Tian W. Recruited CD68(+)CD206(+) macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration. Bioact Mater. 2021;6:1051–72.

CAS  PubMed  Google Scholar 

Yang B, Chen G, Li J, Zou Q, Xie D, Chen Y, Wang H, Zheng X, Long J, Tang W, et al. Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix - based scaffold. Biomaterials. 2012;33:2449–61.

Article  CAS  PubMed  Google Scholar 

Sun J, Li J, Li H, Yang H, Chen J, Yang B, Huo F, Guo W, Tian W. tBHQ suppresses osteoclastic resorption in xenogeneic-treated dentin matrix-based scaffolds. Adv Healthc Mater. 2017;6:1601112.

Article  Google Scholar 

Lan T, Chen J, Zhang J, Huo F, Han X, Zhang Z, Xu Y, Huang Y, Liao L, Xie L, et al. Xenoextracellular matrix-rosiglitazone complex-mediated immune evasion promotes xenogenic bioengineered root regeneration by altering M1/M2 macrophage polarization. Biomaterials. 2021;276: 121066.

Article  CAS  PubMed  Google Scholar 

Rieder E, Steinacher-Nigisch A, Weigel G. Human immune-cell response towards diverse xenogeneic and allogeneic decellularized biomaterials. Int J Surg. 2016;36:347–51.

Article  PubMed  Google Scholar 

Bădilă AE, Rădulescu DM, Ilie A, Niculescu A-G, Grumezescu AM, Rădulescu AR. Bone regeneration and oxidative stress: an updated overview. Antioxidants. 2022. https://doi.org/10.3390/antiox11020318.

Article  PubMed  PubMed Central  Google Scholar 

Sies H, Berndt C, Jones DP. Oxidative stress. Annu Rev Biochem. 2017;86:715–48.

Article  CAS  PubMed  Google Scholar 

Thompson E, Brain JG, Ali S, Kirby JA. Oxidative-stress-induced biosignatures: a predictor of allograft dysfunction? Lancet. 2016;387:S100.

Article  Google Scholar 

Mouthuy PA, Snelling SJB, Dakin SG, Milkovic L, Gasparovic AC, Carr AJ, Zarkovic N. Biocompatibility of implantable materials: an oxidative stress viewpoint. Biomaterials. 2016;109:55–68.

Article  CAS  PubMed  Google Scholar 

Shiekh PA, Singh A, Kumar A. Engineering bioinspired antioxidant materials promoting cardiomyocyte functionality and maturation for tissue engineering application. ACS Appl Mater Interfaces. 2018;10:3260–73.

Article  CAS  PubMed  Google Scholar 

Shiekh PA, Singh A, Kumar A. Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing. Biomaterials. 2020;249: 120020.

Article  CAS  PubMed  Google Scholar 

Zheng K, Torre E, Bari A, Taccardi N, Cassinelli C, Morra M, Fiorilli S, Vitale-Brovarone C, Iviglia G, Boccaccini AR. Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities. Mater Today Bio. 2020;5: 100041.

Article  PubMed  PubMed Central  Google Scholar 

van Niel G, Carter DRF, Clayton A, Lambert DW, Raposo G, Vader P. Challenges and directions in studying cell–cell communication by extracellular vesicles. Nat Rev Mol Cell Biol. 2022;23:369–82.

Article  PubMed  Google Scholar 

Cocozza F, Grisard E, Martin-Jaular L, Mathieu M, Thery C. SnapShot: extracellular vesicles. Cell. 2020;182:262-262 e261.

Article  CAS  PubMed  Google Scholar 

Cheng L, Hill AF. Therapeutically harnessing extracellular vesicles. Nat Rev Drug Discov. 2022;21:379–99.

Article  CAS  PubMed  Google Scholar 

Jiang Y, Li J, Xue X, Yin Z, Xu K, Su J. Engineered extracellular vesicles for bone therapy. Nano Today. 2022;44: 101487.

Article  CAS  Google Scholar 

Kuang Y, Zheng X, Zhang L, Ai X, Venkataramani V, Kilic E, Hermann DM, Majid A, Bähr M, Doeppner TR. Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25. J Extracell Vesicles. 2020. https://doi.org/10.1002/jev2.12024.

Article  PubMed  PubMed Central  Google Scholar 

Eirin A, Zhu XY, Puranik AS, Tang H, McGurren KA, van Wijnen AJ, Lerman A, Lerman LO. Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation. Kidney Int. 2017;92:114–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Liu T, Song K, Fan X, Ma X, Cui Z. Adipose-derived stem cell: a better stem cell than BMSC. Cell Res. 2008;18:S165–S165.

Article  Google Scholar 

Xiao X, Xu M, Yu H, Wang L, Li X, Rak J, Wang S, Zhao RC. Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src. Signal Transduct Target Ther. 2021;6:354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu C, Zhai Z, Ying H, Lu L, Zhang J, Zeng Y. Curcumin primed ADMSCs derived small extracellular vesicle exert enhanced protective effects on osteoarthritis by inhibiting oxidative stress and chondrocyte apoptosis. J Nanobiotechnology. 2022;20:123.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao J, Zheng J, Cai J, Zeng K, Zhou C, Zhang J, Li S, Li H, Chen L, He L, et al. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate rat hepatic ischemia-reperfusion injury by suppressing oxidative stress and neutrophil inflammatory response. FASEB J. 2019;33:1695–710.

Article  CAS  PubMed  Google Scholar 

Chan BKY, Elmasry M, Forootan SS, Russomanno G, Bunday TM, Zhang F, Brillant N, Starkey Lewis PJ, Aird R, Ricci E, et al. Pharmacological activation of Nrf2 enhances functional liver regeneration. Hepatology. 2021;74:973–86.

Article  CAS  PubMed  Google Scholar 

Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010;12:213–23.

Article  CAS  PubMed  Google Scholar 

Wen Z, Hou W, Wu W, Zhao Y, Dong X, Bai X, Peng L, Song L. 6′-O-Galloylpaeoniflorin attenuates cerebral ischemia reperfusion-induced neuroinflammation and oxidative stress via PI3K/Akt/Nrf2 activation. Oxid Med Cell Longev. 2018;2018:8678267.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, et al. Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways. Free Radic Biol Med. 2018;120:228–38.

Article  PubMed  Google Scholar 

Lai TT, Yang CM, Yang CH. Astaxanthin protects retinal photoreceptor cells against high glucose-induced oxidative stress by induction of antioxidant enzymes via the PI3K/Akt/Nrf2 pathway. Antioxidants (Basel). 2020;9:729.

Article  CAS  PubMed  Google Scholar 

Ying S, Tan M, Feng G, Kuang Y, Chen D, Li J, Song J. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative stress. Theranostics. 2020;10:9789–807.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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