Discovery of a novel lipid metabolism-related gene signature to predict outcomes and the tumor immune microenvironment in gastric cancer by integrated analysis of single-cell and bulk RNA sequencing

Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, Kramer J, Siegel RL. Cancer treatment and survivorship statistics, 2022. Cancer J Clin. 2022;72(5):409–36.

Article  Google Scholar 

Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J. 2022;135(5):584–90.

Article  PubMed  PubMed Central  Google Scholar 

Cronin KA, Scott S, Firth AU, Sung H, Henley SJ, Sherman RL, Siegel RL, Anderson RN, Kohler BA, Benard VB, et al. Annual report to the nation on the status of cancer, part 1: National cancer statistics. Cancer. 2022;128(24):4251–84.

Article  PubMed  Google Scholar 

Zhao Y, Zhan J, Wang Y, Wang D. The Relationship between Plant-based Diet and Risk of Digestive System cancers: a Meta-analysis based on 3,059,009 subjects. Front Public Health. 2022;10: 892153.

Article  PubMed  PubMed Central  Google Scholar 

Onoyama T, Ishikawa S, Isomoto H. Gastric cancer and genomics: review of literature. J Gastroenterol. 2022;57(8):505–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnston FM, Beckman M. Updates on management of gastric Cancer. Curr Oncol Rep. 2019;21(8):67.

Article  PubMed  Google Scholar 

Schoeler M, Caesar R. Dietary lipids, gut microbiota and lipid metabolism. Rev Endocr Metab Disord. 2019;20(4):461–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lim SA, Su W, Chapman NM, Chi H. Lipid metabolism in T cell signaling and function. Nat Chem Biol. 2022;18(5):470–81.

Article  CAS  PubMed  Google Scholar 

Zechner R, Zimmermann R, Eichmann TO, Kohlwein SD, Haemmerle G, Lass A, Madeo F. FAT SIGNALS–lipases and lipolysis in lipid metabolism and signaling. Cell Metabol. 2012;15(3):279–91.

Article  CAS  Google Scholar 

Jeon S, Carr R. Alcohol effects on hepatic lipid metabolism. J Lipid Res. 2020;61(4):470–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bacci M, Lorito N, Smiriglia A, Morandi A. Fat and Furious: lipid metabolism in Antitumoral Therapy Response and Resistance. Trends in cancer. 2021;7(3):198–213.

Article  CAS  PubMed  Google Scholar 

Walther TC, Farese RV Jr. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012;81:687–714.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yi M, Li J, Chen S, Cai J, Ban Y, Peng Q, Zhou Y, Zeng Z, Peng S, Li X, et al. Emerging role of lipid metabolism alterations in Cancer stem cells. J Exp Clin Cancer Res. 2018;37(1):118.

Article  PubMed  PubMed Central  Google Scholar 

Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr. Cellular fatty acid metabolism and cancer. Cell Metabol. 2013;18(2):153–61.

Article  CAS  Google Scholar 

Huang J, Wang J, He H, Huang Z, Wu S, Chen C, Liu W, Xie L, Tao Y, Cong L, et al. Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer. Int J Biol Sci. 2021;17(15):4493–513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai F, Jin S, Chen G. The Effect of Lipid Metabolism on CD4(+) T Cells. Mediators Inflamm. 2021;2021: 6634532.

Article  PubMed  PubMed Central  Google Scholar 

Yan J, Horng T. Lipid metabolism in regulation of macrophage functions. Trends Cell Biol. 2020;30(12):979–89.

Article  CAS  PubMed  Google Scholar 

Li D, Li Y. The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct Target Therapy. 2020;5(1):108.

Article  Google Scholar 

Hu B, Lin JZ, Yang XB, Sang XT. Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: a review. Cell Prolif. 2020;53(3): e12772.

Article  PubMed  PubMed Central  Google Scholar 

Remmerie A, Scott CL. Macrophages and lipid metabolism. Cell Immunol. 2018;330:27–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui MY, Yi X, Zhu DX, Wu J. The role of lipid metabolism in gastric Cancer. Front Oncol. 2022;12: 916661.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiong Z, Lin Y, Yu Y, Zhou X, Fan J, Rog CJ, Cai K, Wang Z, Chang Z, Wang G, et al. Exploration of lipid metabolism in gastric Cancer: a novel prognostic genes expression Profile. Front Oncol. 2021;11: 712746.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Zhang L, Qiu Z, Deng W, Wang W. Key molecules of fatty acid metabolism in gastric Cancer. Biomolecules. 2022;12(5):706.

Article  PubMed  PubMed Central  Google Scholar 

Huang S, Guo Y, Li Z, Zhang Y, Zhou T, You W, Pan K, Li W. A systematic review of metabolomic profiling of gastric cancer and Esophageal cancer. Cancer Biol Med. 2020;17(1):181–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo C, Zhang L, Zhao M, Ai Y, Liao W, Wan L, Liu Q, Li S, Zeng J, Ma X, et al. Targeting lipid metabolism with natural products: a novel strategy for gastrointestinal cancer therapy. Phytother Res. 2023;37(5):2036–50.

Article  CAS  PubMed  Google Scholar 

Papalexi E, Satija R. Single-cell RNA sequencing to explore immune cell heterogeneity. Nat Rev Immunol. 2018;18(1):35–45.

Article  CAS  PubMed  Google Scholar 

Luecken MD, Theis FJ. Current best practices in single-cell RNA-seq analysis: a tutorial. Mol Syst Biol. 2019;15(6): e8746.

Article  PubMed  PubMed Central  Google Scholar 

Lei Y, Tang R, Xu J, Wang W, Zhang B, Liu J, Yu X, Shi S. Applications of single-cell sequencing in cancer research: progress and perspectives. J Hematol Oncol. 2021;14(1):91.

Article  PubMed  PubMed Central  Google Scholar 

Li X, Wang CY. From bulk, single-cell to spatial RNA sequencing. Int J Oral Sci. 2021;13(1):36.

Article  PubMed  PubMed Central  Google Scholar 

Grün D, van Oudenaarden A. Design and analysis of single-cell sequencing experiments. Cell. 2015;163(4):799–810.

Article  PubMed  Google Scholar 

Suvà ML, Tirosh I. Single-cell RNA sequencing in Cancer: lessons learned and Emerging challenges. Mol Cell. 2019;75(1):7–12.

Article  PubMed  Google Scholar 

Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 2013;14: 7.

Article  PubMed  PubMed Central  Google Scholar 

Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet (London England). 2020;396(10251):635–48.

Article  CAS  PubMed  Google Scholar 

Chia NY, Tan P. Molecular classification of gastric cancer. Ann Oncol. 2016;27(5):763–9.

Article  PubMed  Google Scholar 

Guggenheim DE, Shah MA. Gastric cancer epidemiology and risk factors. J Surg Oncol. 2013;107(3):230–6.

Article  PubMed  Google Scholar 

Puliga E, Corso S, Pietrantonio F, Giordano S. Microsatellite instability in gastric Cancer: between lights and shadows. Cancer Treat Rev. 2021;95: 102175.

Article  PubMed  Google Scholar 

Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol. 2006;12(3):354–62.

Article  PubMed  PubMed Central  Google Scholar 

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